PDP5_ARATH
ID PDP5_ARATH Reviewed; 632 AA.
AC Q9LYZ0;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=PWWP domain-containing protein 5 {ECO:0000303|PubMed:29314758};
GN Name=PDP5 {ECO:0000303|PubMed:29314758};
GN OrderedLocusNames=At5g02950 {ECO:0000312|Araport:AT5G02950};
GN ORFNames=F9G14.260 {ECO:0000312|EMBL:CAB86049.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DISRUPTION PHENOTYPE, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=29314758; DOI=10.1111/jipb.12630;
RA Zhou J.X., Liu Z.W., Li Y.Q., Li L., Wang B., Chen S., He X.J.;
RT "Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and
RT regulate flowering time.";
RL J. Integr. Plant Biol. 60:362-368(2018).
CC -!- FUNCTION: May influence gene expression by regulating the function of
CC the PRC2 complex and modulating H3K27me3 level.
CC {ECO:0000250|UniProtKB:Q9FNE4}.
CC -!- SUBUNIT: Component of the PRC2 (polycomb repressive complex 2) complex
CC which regulates histone methylation on histone H3K27.
CC {ECO:0000250|UniProtKB:Q9FNE4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- DISRUPTION PHENOTYPE: No visible flowering phenotype.
CC {ECO:0000269|PubMed:29314758}.
CC -!- SIMILARITY: Belongs to the PDP family. {ECO:0000305}.
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DR EMBL; AL162973; CAB86049.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90539.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68804.1; -; Genomic_DNA.
DR EMBL; AB493732; BAH30570.1; -; mRNA.
DR PIR; T48316; T48316.
DR RefSeq; NP_001330526.1; NM_001342681.1.
DR RefSeq; NP_195915.1; NM_120373.3.
DR AlphaFoldDB; Q9LYZ0; -.
DR SMR; Q9LYZ0; -.
DR PaxDb; Q9LYZ0; -.
DR PRIDE; Q9LYZ0; -.
DR ProteomicsDB; 189241; -.
DR EnsemblPlants; AT5G02950.1; AT5G02950.1; AT5G02950.
DR EnsemblPlants; AT5G02950.2; AT5G02950.2; AT5G02950.
DR GeneID; 831728; -.
DR Gramene; AT5G02950.1; AT5G02950.1; AT5G02950.
DR Gramene; AT5G02950.2; AT5G02950.2; AT5G02950.
DR KEGG; ath:AT5G02950; -.
DR Araport; AT5G02950; -.
DR TAIR; locus:2151291; AT5G02950.
DR eggNOG; ENOG502QTFR; Eukaryota.
DR HOGENOM; CLU_005330_1_1_1; -.
DR InParanoid; Q9LYZ0; -.
DR OMA; KRLACFP; -.
DR OrthoDB; 192789at2759; -.
DR PhylomeDB; Q9LYZ0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LYZ0; baseline and differential.
DR GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR GO; GO:0098532; P:histone H3-K27 trimethylation; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..632
FT /note="PWWP domain-containing protein 5"
FT /id="PRO_0000453273"
FT DOMAIN 97..158
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 310..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 352..359
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 310..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 70512 MW; FBD5ED38D7946406 CRC64;
MSTEPEGVES DSNADFAINA SSFDYGMAHT SETLADPMSF QAQDLVVNLT GVERKVFVSA
RDDKDSLCNG VDFDADSDLL KNKDKKGFSK ENLKLFDSDL VWAKLRSYPW WPGLVFDKSV
ASKAAMRHFK KGNVLVAYFG DCTFAWNNAS QIKPFHQNFS QMQEQSNSAE FRDAIDCALD
EVSRRVEFGL SCSCVSEEAY NKLKTQNIIN AGIREDSSVR YGGDKLSDGI SFEPAKLVDY
MKHLACFPCY DATEKLQFVI NRAQVLAFQQ WKDYSHFIDY ETFVRSVESA ATLASLPEVN
MDEGISAKKR KTDYKDNAEQ TKEKTLSDLT VKKRCGSRST EKLDGKSHSE KKRKVESSES
GKSEKRIKKS QQKEDSVSKH SNEESLLSVG DTNKLQKTAE PCHGTGVENE MNSLTPTLKP
CRASKSTEVE NEKTKKPRHQ ELAERKISSP DEMLSSLHAA NTSTGIPDSI NIDPSNYEDF
EKFINELFCS KLNGDSKKAS ITETSEPCDK KDSAEEEILP ANKEITGSGS KEQIGLKDCS
ADSLPPYALV LNFADSGSVP SEEKLNEIFK RYGPLHESKT KVTMKGKRAK VVFKRGEDAK
TAFSSAGKYS IFGPSLLSYR LEYVCPKRKK TT
