ID   PDP6_ARATH              Reviewed;         652 AA.
AC   Q9LK91;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=PWWP domain-containing protein 6 {ECO:0000303|PubMed:29314758};
GN   Name=PDP6 {ECO:0000303|PubMed:29314758};
GN   OrderedLocusNames=At3g27860 {ECO:0000312|Araport:AT3G27860};
GN   ORFNames=K16N12.8 {ECO:0000312|EMBL:BAB02532.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   INTERACTION WITH MSI5, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=29314758; DOI=10.1111/jipb.12630;
RA   Zhou J.X., Liu Z.W., Li Y.Q., Li L., Wang B., Chen S., He X.J.;
RT   "Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and
RT   regulate flowering time.";
RL   J. Integr. Plant Biol. 60:362-368(2018).
CC   -!- FUNCTION: May influence gene expression by regulating the function of
CC       the PRC2 complex and modulating H3K27me3 level.
CC       {ECO:0000250|UniProtKB:Q9FNE4}.
CC   -!- SUBUNIT: Binds to MSI5 (PubMed:29314758). Component of the PRC2
CC       (polycomb repressive complex 2) complex which regulates histone
CC       methylation on histone H3K27 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9FNE4, ECO:0000269|PubMed:29314758}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC   -!- SIMILARITY: Belongs to the PDP family. {ECO:0000305}.
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DR   EMBL; AP000371; BAB02532.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE77373.1; -; Genomic_DNA.
DR   EMBL; CP002686; ANM63487.1; -; Genomic_DNA.
DR   RefSeq; NP_001319658.1; NM_001338913.1.
DR   RefSeq; NP_189424.1; NM_113702.2.
DR   AlphaFoldDB; Q9LK91; -.
DR   PaxDb; Q9LK91; -.
DR   PRIDE; Q9LK91; -.
DR   ProteomicsDB; 187425; -.
DR   EnsemblPlants; AT3G27860.1; AT3G27860.1; AT3G27860.
DR   EnsemblPlants; AT3G27860.2; AT3G27860.2; AT3G27860.
DR   GeneID; 822406; -.
DR   Gramene; AT3G27860.1; AT3G27860.1; AT3G27860.
DR   Gramene; AT3G27860.2; AT3G27860.2; AT3G27860.
DR   KEGG; ath:AT3G27860; -.
DR   Araport; AT3G27860; -.
DR   TAIR; locus:2086455; AT3G27860.
DR   eggNOG; ENOG502QQX0; Eukaryota.
DR   HOGENOM; CLU_489677_0_0_1; -.
DR   InParanoid; Q9LK91; -.
DR   OMA; IEANEGM; -.
DR   OrthoDB; 1167092at2759; -.
DR   PhylomeDB; Q9LK91; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LK91; baseline and differential.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0098532; P:histone H3-K27 trimethylation; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR000313; PWWP_dom.
DR   Pfam; PF00855; PWWP; 1.
DR   PROSITE; PS50812; PWWP; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..652
FT                   /note="PWWP domain-containing protein 6"
FT                   /id="PRO_0000453274"
FT   DOMAIN          63..126
FT                   /note="PWWP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           272..279
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
SQ   SEQUENCE   652 AA;  73666 MW;  D567964FFE1F4CE6 CRC64;
     MGNILPTGSR VSENEGSDDN KLKEHDVKME NVKEDSEQIG DNVRSGVSSL RDNFEELENG
     FHVGDFVWGE EANSQQWWPG QIYDSLDASD LALKTMQKGK LLVAYFGDGS FFGWCNPLEL
     KPFLENFKEF SKMSDSRRFL LAVEDAVREI GEHVEKFLVC DDAALVSSVA LNLGIKDGVV
     VPDVRRKIIS SLVLENPGVV LEDVKRLAMT VRFDDLLEIE VLRRKISAFY RCKGRFDLAK
     FDEHRYIIGL EDKEHESCQR LLRKCSGFAS KKRKCGDVAT TGSTTLRKKR LSEVSKIETA
     EKEISNGKSL SSRKRKSKRG LDENDDDGIE KREESNDSNH LEESEKKDDL ATPLASICKR
     LNVDVSSCVK RCNGNGEAIL QTGKRERKKS KYLSPEYMTD FSCRARKIKI ESAESSQIQV
     AVRMTTPNTA IDVVKLGATP EEMLALIRAA ALNAQYPKDY NSTSCDMVRE FVSNYRSFNN
     KRNLSDVEKQ PEVKQEIVDE KEKTRNEPGV ELYIKTGFGS TLPSKDDLIK TYEKFGALDK
     ERSYMFNNNS CSCVAFVNAS DGEEAFNRSL EKCPFATTST VTFKLEYPSS ASSEKKEAET
     RKGVTEIECL KEKLEGIRAL LDQSEGKITE ELKMKLEDES RNLLDKVRKM II