ID   PDPFA_DANRE             Reviewed;         117 AA.
AC   Q6PFP3;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Pancreatic progenitor cell differentiation and proliferation factor A;
DE   AltName: Full=Exocrine differentiation and proliferation factor A;
DE            Short=Exocrine differentiation and proliferation factor;
GN   Name=ppdpfa; Synonyms=exdpf, exdpfa;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE,
RP   AND INDUCTION.
RX   PubMed=19067490; DOI=10.1371/journal.pbio.0060293;
RA   Jiang Z., Song J., Qi F., Xiao A., An X., Liu N.-A., Zhu Z., Zhang B.,
RA   Lin S.;
RT   "Exdpf is a key regulator of exocrine pancreas development controlled by
RT   retinoic acid and ptf1a in zebrafish.";
RL   PLoS Biol. 6:E293-E293(2008).
CC   -!- FUNCTION: Probable regulator of exocrine pancreas development.
CC       {ECO:0000269|PubMed:19067490}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in the exocrine cells during
CC       pancreas development. {ECO:0000269|PubMed:19067490}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       Expression increases between 1 dpf and 2 dpf when the exocrine pancreas
CC       starts to develop and is highest between 2 dpf and 5 dpf. Starts to
CC       express in the pancreatic area at 33 hpf. Later in development, the
CC       strongest domain of expression appears in the pancreas. Cells
CC       expressing are located about 1 somite anterior to the cluster of
CC       preproinsulin-positive cells, just before exocrine specification
CC       begins. By 36 hpf, expressing cells start to contact the
CC       preproinsulinpositive cells as a result of gut rotation. These
CC       expressing cells continue to grow posteriorly to form a typical
CC       pancreas-like shape at 3 dpf. From 33 hpf to 3 dpf, there is no overlap
CC       between expressing cells and preproinsulinpositive cells, indicating
CC       that expression is excluded from endocrine cells. Conversely,
CC       expression completely overlaps with trypsin expression at 3 dpf.
CC       {ECO:0000269|PubMed:19067490}.
CC   -!- INDUCTION: Expression is directly regulated by pancreas-specific
CC       transcription factor ptf1a. Probably also regulated by retinoic acid
CC       (RA). {ECO:0000269|PubMed:19067490}.
CC   -!- DISRUPTION PHENOTYPE: Impaired exocrine cell differentiation and
CC       growth. Loss or significant reduction of exocrine cells are due to
CC       lineage-specific cell cycle arrest but not apoptosis. The endocrine
CC       cell mass appear normal. Cell cycle arrest is mediated by up-regulation
CC       of cell cycle inhibitor genes cdkn1a, cdkn1b, and cyclin gccng1.
CC       {ECO:0000269|PubMed:19067490}.
CC   -!- SIMILARITY: Belongs to the PPDPF family. {ECO:0000305}.
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DR   EMBL; BC057474; AAH57474.1; -; mRNA.
DR   RefSeq; NP_956373.1; NM_200079.1.
DR   AlphaFoldDB; Q6PFP3; -.
DR   STRING; 7955.ENSDARP00000031112; -.
DR   PaxDb; Q6PFP3; -.
DR   Ensembl; ENSDART00000032996; ENSDARP00000031112; ENSDARG00000007682.
DR   GeneID; 338304; -.
DR   KEGG; dre:338304; -.
DR   CTD; 338304; -.
DR   ZFIN; ZDB-GENE-030219-204; ppdpfa.
DR   eggNOG; ENOG502S1KD; Eukaryota.
DR   GeneTree; ENSGT00390000009113; -.
DR   HOGENOM; CLU_157362_0_0_1; -.
DR   InParanoid; Q6PFP3; -.
DR   OMA; VTCIARQ; -.
DR   OrthoDB; 1540584at2759; -.
DR   PhylomeDB; Q6PFP3; -.
DR   TreeFam; TF333000; -.
DR   PRO; PR:Q6PFP3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 8.
DR   Bgee; ENSDARG00000007682; Expressed in cardiac ventricle and 52 other tissues.
DR   ExpressionAtlas; Q6PFP3; baseline and differential.
DR   GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR   GO; GO:0008283; P:cell population proliferation; IMP:ZFIN.
DR   GO; GO:0031017; P:exocrine pancreas development; IMP:ZFIN.
DR   InterPro; IPR026754; PPDPF.
DR   PANTHER; PTHR14572; PTHR14572; 1.
DR   Pfam; PF15060; PPDFL; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Reference proteome.
FT   CHAIN           1..117
FT                   /note="Pancreatic progenitor cell differentiation and
FT                   proliferation factor A"
FT                   /id="PRO_0000359766"
FT   REGION          22..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   117 AA;  12645 MW;  C9E3A51CA8E773A9 CRC64;
     MAAIPSSGSL IATHDYYRRR IGSTSSNSSC SSSEYTGEVI PHPPGLARQD SGHWWSSFFF
     GKQNQMGTPN GFESQQKTGT YTVTNGQVTC VAREIVMKRH LSESSDSGKE PGSPLPS