PDPFL_HUMAN
ID PDPFL_HUMAN Reviewed; 84 AA.
AC Q8WWR9; G3V137; Q8WVI1;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Pancreatic progenitor cell differentiation and proliferation factor-like protein;
DE AltName: Full=Exocrine differentiation and proliferation factor-like protein;
GN Name=PPDPFL {ECO:0000312|HGNC:HGNC:31745};
GN Synonyms=C8orf22 {ECO:0000312|HGNC:HGNC:31745};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RA Stanchi F., Lanfranchi G.;
RT "Full-length sequencing of 100 cDNA clones from human adult skeletal
RT muscle.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=11329013; DOI=10.1038/88107;
RA Harrington J.J., Sherf B., Rundlett S., Jackson P.D., Perry R., Cain S.,
RA Leventhal C., Thornton M., Ramachandran R., Whittington J., Lerner L.,
RA Costanzo D., McElligott K., Boozer S., Mays R., Smith E., Veloso N.,
RA Klika A., Hess J., Cothren K., Lo K., Offenbacher J., Danzig J., Ducar M.;
RT "Creation of genome-wide protein expression libraries using random
RT activation of gene expression.";
RL Nat. Biotechnol. 19:440-445(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8WWR9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WWR9-2; Sequence=VSP_017651;
CC Name=3;
CC IsoId=Q8WWR9-3; Sequence=VSP_044862;
CC -!- SIMILARITY: Belongs to the PPDPF family. {ECO:0000305}.
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DR EMBL; AJ276240; CAC81690.1; -; mRNA.
DR EMBL; BG202040; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC044893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471068; EAW86701.1; -; Genomic_DNA.
DR EMBL; BC017981; AAH17981.1; -; mRNA.
DR CCDS; CCDS47854.1; -. [Q8WWR9-2]
DR CCDS; CCDS59101.1; -. [Q8WWR9-1]
DR CCDS; CCDS59102.1; -. [Q8WWR9-3]
DR RefSeq; NP_001007177.1; NM_001007176.4. [Q8WWR9-2]
DR RefSeq; NP_001243525.1; NM_001256596.1. [Q8WWR9-3]
DR RefSeq; NP_001243526.1; NM_001256597.1. [Q8WWR9-3]
DR RefSeq; NP_001243527.1; NM_001256598.1. [Q8WWR9-1]
DR AlphaFoldDB; Q8WWR9; -.
DR BioGRID; 138895; 7.
DR STRING; 9606.ENSP00000304926; -.
DR BioMuta; PPDPFL; -.
DR MassIVE; Q8WWR9; -.
DR PaxDb; Q8WWR9; -.
DR PeptideAtlas; Q8WWR9; -.
DR PRIDE; Q8WWR9; -.
DR Antibodypedia; 71452; 28 antibodies from 8 providers.
DR DNASU; 492307; -.
DR Ensembl; ENST00000303202.8; ENSP00000304926.8; ENSG00000168333.14. [Q8WWR9-1]
DR Ensembl; ENST00000399653.8; ENSP00000382561.4; ENSG00000168333.14. [Q8WWR9-2]
DR Ensembl; ENST00000517663.5; ENSP00000430392.1; ENSG00000168333.14. [Q8WWR9-3]
DR Ensembl; ENST00000522267.6; ENSP00000428773.1; ENSG00000168333.14. [Q8WWR9-3]
DR GeneID; 492307; -.
DR KEGG; hsa:492307; -.
DR MANE-Select; ENST00000522267.6; ENSP00000428773.1; NM_001256597.2; NP_001243526.1. [Q8WWR9-3]
DR UCSC; uc003xqq.6; human. [Q8WWR9-1]
DR CTD; 492307; -.
DR DisGeNET; 492307; -.
DR GeneCards; PPDPFL; -.
DR HGNC; HGNC:31745; PPDPFL.
DR HPA; ENSG00000168333; Tissue enriched (skeletal).
DR neXtProt; NX_Q8WWR9; -.
DR OpenTargets; ENSG00000168333; -.
DR PharmGKB; PA134881233; -.
DR VEuPathDB; HostDB:ENSG00000168333; -.
DR eggNOG; ENOG502S9AD; Eukaryota.
DR GeneTree; ENSGT00390000009113; -.
DR HOGENOM; CLU_2621341_0_0_1; -.
DR InParanoid; Q8WWR9; -.
DR OMA; WIKSFFH; -.
DR OrthoDB; 1591428at2759; -.
DR PhylomeDB; Q8WWR9; -.
DR TreeFam; TF341088; -.
DR PathwayCommons; Q8WWR9; -.
DR BioGRID-ORCS; 492307; 10 hits in 1058 CRISPR screens.
DR GenomeRNAi; 492307; -.
DR Pharos; Q8WWR9; Tdark.
DR PRO; PR:Q8WWR9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8WWR9; protein.
DR Bgee; ENSG00000168333; Expressed in tibialis anterior and 87 other tissues.
DR Genevisible; Q8WWR9; HS.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR InterPro; IPR026754; PPDPF.
DR PANTHER; PTHR14572; PTHR14572; 1.
DR Pfam; PF15060; PPDFL; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..84
FT /note="Pancreatic progenitor cell differentiation and
FT proliferation factor-like protein"
FT /id="PRO_0000228102"
FT VAR_SEQ 79..84
FT /note="SLSGRS -> MNS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017651"
FT VAR_SEQ 79..84
FT /note="SLSGRS -> LQMSTL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11329013"
FT /id="VSP_044862"
SQ SEQUENCE 84 AA; 9188 MW; 9D325334C3C3FC69 CRC64;
MASVPSIGCL LARNQYYRKS SVSSVSSLTS SDSVNFIDDD KPQQGLPEVA ESTWWFKSFF
HSEPVLSNVR IKDLSATGSL SGRS
