ID   ASR1_ASHGO              Reviewed;         328 AA.
AC   Q75DC2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Alcohol-sensitive RING finger protein 1;
GN   Name=ASR1; OrderedLocusNames=ABR104W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for tolerance to alcohol. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Predominantly cytoplasmic. Accumulates in the nucleus specifically
CC       upon alcohol stress. {ECO:0000250}.
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DR   EMBL; AE016815; AAS50875.1; -; Genomic_DNA.
DR   RefSeq; NP_983051.1; NM_208404.1.
DR   AlphaFoldDB; Q75DC2; -.
DR   STRING; 33169.AAS50875; -.
DR   EnsemblFungi; AAS50875; AAS50875; AGOS_ABR104W.
DR   GeneID; 4619155; -.
DR   KEGG; ago:AGOS_ABR104W; -.
DR   eggNOG; KOG0800; Eukaryota.
DR   HOGENOM; CLU_071677_0_0_1; -.
DR   InParanoid; Q75DC2; -.
DR   OMA; ESINECC; -.
DR   Proteomes; UP000000591; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..328
FT                   /note="Alcohol-sensitive RING finger protein 1"
FT                   /id="PRO_0000055759"
FT   ZN_FING         18..61
FT                   /note="RING-type 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         129..177
FT                   /note="RING-type 2; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   328 AA;  37536 MW;  E9AC1534B341B873 CRC64;
     MLKHISSHIA MGCPQDECSI CWESMPSGVG RLMPCGHEYH LACIRKWFHL HSGNRSCPVC
     RTEASVLVDT DHEVKIDLSV GQLLDFYGLL DEIGSQLLAI TLQDHSTQDD EVNEEGLAEQ
     RAQLTLVQCG ICGEMNGDID TCCNRCHHMY HHSCLGQLLV EVNAEREQGW SHCIFCYEQL
     VPLYISGARR VLSLQDRGVH RGRVRNNRSI LTELIYERSG VLVHGIEDQH ASQHDINDIE
     HSWHLLEQNR QRKQLEYQDK CKIQAHVRRI LDHYYHCAKV TKAQYTFINK KVSQTLYALS
     RGVYPAVDLD YDGIAKTLIL DEMEKLSS