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PDPR_BOVIN
ID   PDPR_BOVIN              Reviewed;         878 AA.
AC   O46504;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial;
DE            Short=PDPr;
DE   Flags: Precursor;
GN   Name=PDPR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-45; 216-229; 350-362;
RP   370-377; 385-399; 419-442; 445-474; 490-497 AND 656-665, AND SUBUNIT.
RX   PubMed=9395502; DOI=10.1074/jbc.272.50.31625;
RA   Lawson J.E., Park S.H., Mattison A.R., Yan J., Reed L.J.;
RT   "Cloning, expression, and properties of the regulatory subunit of bovine
RT   pyruvate dehydrogenase phosphatase.";
RL   J. Biol. Chem. 272:31625-31629(1997).
RN   [2]
RP   FUNCTION.
RX   PubMed=8643510; DOI=10.1073/pnas.93.10.4953;
RA   Yan J., Lawson J.E., Reed L.J.;
RT   "Role of the regulatory subunit of bovine pyruvate dehydrogenase
RT   phosphatase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:4953-4956(1996).
CC   -!- FUNCTION: Decreases the sensitivity of PDP1 to magnesium ions, and this
CC       inhibition is reversed by the polyamine spermine.
CC       {ECO:0000269|PubMed:8643510}.
CC   -!- SUBUNIT: Heterodimer of a catalytic (PDP1) and a regulatory (PDPR)
CC       subunit. {ECO:0000269|PubMed:9395502}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000305}.
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DR   EMBL; AF026954; AAC48785.1; -; mRNA.
DR   RefSeq; NP_777206.1; NM_174781.2.
DR   AlphaFoldDB; O46504; -.
DR   SMR; O46504; -.
DR   STRING; 9913.ENSBTAP00000021895; -.
DR   PaxDb; O46504; -.
DR   PRIDE; O46504; -.
DR   GeneID; 286844; -.
DR   KEGG; bta:286844; -.
DR   CTD; 55066; -.
DR   eggNOG; KOG2844; Eukaryota.
DR   InParanoid; O46504; -.
DR   OrthoDB; 137947at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..26
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..878
FT                   /note="Pyruvate dehydrogenase phosphatase regulatory
FT                   subunit, mitochondrial"
FT                   /id="PRO_0000328739"
SQ   SEQUENCE   878 AA;  98857 MW;  A8658C5605164E6D CRC64;
     MLPRLLAVVR GPGSCRGWRE GSPARGSASA TVAPPVALPA QAQVVVCGGG IMGTSVAYHL
     SKMGWKDVVL LEQGRLAAGS TRFCAGILST ARHLAIEQKM ADYSNKLYHQ LEQETGIQTG
     YTRTGSIFLA QTQDRLISLK RINSRLNVIG IPCEIISPKK VAELHPLLNV HDLVGAMHVP
     EDAVVSSADV ALALASAASQ SGVQIYDRTS ILHVMVKKGQ VAGVETDKGQ IQCQYFVNCA
     GQWAYELGLC SEEPVSIPLH ACEHFYLLTR PWETPLPSST PTVVDADGRI YIRNWQGGIL
     SGGFEKNPKP IFTEGKNQLE IQNLQEDWDH FEPLLSSLLR RMPQLETLEI VKLVNCPETF
     TPDMRCIMGE SPSVRGYFVL VGMNSAGLSF GGGAGKYLAE WMVYGYPSEN VWELDLKRFG
     ALQSSRTFLR HRVMEVMPLL YDLKVPRWDF QTGRQLRTSP LYDRLDAQGA RWMEKHGFER
     PKYFIPPDKD LLALEQSKTF YKPDWFEIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDQA
     LEILQYLFSN DLDVPVGHIV HTGMLNERGG YENDCSIARL SKRSFFMISP TDQQVHCWAW
     LKKYMPEDSN LILEDVTWKY TALNLIGPRT VDVLSELSYA PMTPDHFPSL FCKEMSVGYA
     NGIRVMSMTH TGEPGFMLYI PIEYALHVYN EVMSVGQKYG IRNAGYYALR SLRIEKFFAF
     WGQDLNTLTT PLECGGESRV KLDKGVDFIG RDALLQQRQN GVYNRLTMFI LDDHDTDLDL
     WPWWGEPIYR NGRYVGKTTS SAYGYTLERH VCLGFVHNFS EDTGEEQVVT ADFINRGEYE
     IDIAGHRFQA KAKLYPVPSL LTHKRRKEDV ELSDLHGK
 
 
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