ID   PDPR_MOUSE              Reviewed;         878 AA.
AC   Q7TSQ8; Q6ZPF5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial;
DE            Short=PDPr;
DE   Flags: Precursor;
GN   Name=Pdpr; Synonyms=Kiaa1990;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RA   Jang J.S., Ackerman S.L.;
RT   "An alternatively spliced form of a gene encoding pyruvate dehydrogenase
RT   phosphatase regulatory subunit.";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Decreases the sensitivity of PDP1 to magnesium ions, and this
CC       inhibition is reversed by the polyamine spermine. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a catalytic (PDP1) and a regulatory (PDPR)
CC       subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC98282.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY223867; AAP20649.1; -; mRNA.
DR   EMBL; AK129472; BAC98282.1; ALT_INIT; mRNA.
DR   EMBL; BC120745; AAI20746.1; -; mRNA.
DR   EMBL; BC125425; AAI25426.1; -; mRNA.
DR   CCDS; CCDS22670.1; -.
DR   RefSeq; NP_938050.1; NM_198308.1.
DR   RefSeq; XP_006531147.1; XM_006531084.3.
DR   AlphaFoldDB; Q7TSQ8; -.
DR   SMR; Q7TSQ8; -.
DR   BioGRID; 235328; 3.
DR   STRING; 10090.ENSMUSP00000046639; -.
DR   iPTMnet; Q7TSQ8; -.
DR   PhosphoSitePlus; Q7TSQ8; -.
DR   SwissPalm; Q7TSQ8; -.
DR   EPD; Q7TSQ8; -.
DR   MaxQB; Q7TSQ8; -.
DR   PaxDb; Q7TSQ8; -.
DR   PeptideAtlas; Q7TSQ8; -.
DR   PRIDE; Q7TSQ8; -.
DR   ProteomicsDB; 288091; -.
DR   Antibodypedia; 66437; 66 antibodies from 16 providers.
DR   DNASU; 319518; -.
DR   Ensembl; ENSMUST00000039333; ENSMUSP00000046639; ENSMUSG00000033624.
DR   GeneID; 319518; -.
DR   KEGG; mmu:319518; -.
DR   UCSC; uc009nlw.1; mouse.
DR   CTD; 55066; -.
DR   MGI; MGI:2442188; Pdpr.
DR   VEuPathDB; HostDB:ENSMUSG00000033624; -.
DR   eggNOG; KOG2844; Eukaryota.
DR   GeneTree; ENSGT00940000159082; -.
DR   HOGENOM; CLU_007884_11_0_1; -.
DR   InParanoid; Q7TSQ8; -.
DR   OMA; HAGYYAT; -.
DR   OrthoDB; 137947at2759; -.
DR   PhylomeDB; Q7TSQ8; -.
DR   TreeFam; TF314735; -.
DR   Reactome; R-MMU-204174; Regulation of pyruvate dehydrogenase (PDH) complex.
DR   BioGRID-ORCS; 319518; 0 hits in 72 CRISPR screens.
DR   ChiTaRS; Pdpr; mouse.
DR   PRO; PR:Q7TSQ8; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q7TSQ8; protein.
DR   Bgee; ENSMUSG00000033624; Expressed in parotid gland and 217 other tissues.
DR   ExpressionAtlas; Q7TSQ8; baseline and differential.
DR   Genevisible; Q7TSQ8; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..93
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           94..878
FT                   /note="Pyruvate dehydrogenase phosphatase regulatory
FT                   subunit, mitochondrial"
FT                   /id="PRO_0000328741"
FT   CONFLICT        438
FT                   /note="P -> H (in Ref. 2; BAC98282)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   878 AA;  99230 MW;  16A8C9ED77613525 CRC64;
     MLYRLLSIVQ RQRTSPGWQT WSSARSSTST AEAHSIALPA QAQVVICGGG IMGTSVAYHL
     SKMGWQDIVL LEQGRLAAGS TRFCAGILST ARHSSVEQKM ANYSNKLYHQ LEQETGIQTG
     YLRTGSISLA QTQDRLISLK RINSRLNVVG IPSEIISPKK VAELHPLLNV HDLVGAMYVP
     EDAVVSSADV ALALASAASQ NGVQIYDRTS VLHVLIKKGQ VTGVETDKGQ IECQYFVNCA
     GQWAYELGLS NEEPLSIPLH ACEHFYLLTR PWDTPLQSNT PTIVDADGRI YIRNWQGGIL
     SGGFEKNPKP IFTEGKNQLE IQNLREDWDH FEPLLSSLLR RMPALETLEI LKLVNCPETF
     TPDMKCIMGE SPVVQGYFVL AGMNSAGLSL GGGAGKFLAE WMVYGYPSEN VWELDLQRFG
     ALQSSRTFLR HRVMEVMPLI YDLKVPRWDF QTGRQLRTSP LYDRLDAQGA RWMEKHGFER
     PKYFVPPNKD LLALEQSKTF YKPDWFDIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDEA
     LESLQYLFCN DLDVPVGHIV HTGMLNEYGG YENDCSIARL TKRSFFMISP TDQQVHCWAW
     LNKYLPKDSN LLLEDVTWKY TALNLIGPRA VDVLSELSYA PMTPDHFPTL FCKEMSVGYA
     NGIRVMSMTH TGEPGFMLYI PIEYALHVYN EVMSVGQKYG IRNAGYYALR SLRIEKFFAF
     WGQDLNTLTT PLECGGESRV KLEKGIDFIG RDALLQQKQT GVYKRLAMFI LDDHDTDLDL
     WPWWGEPIYR NGKYAGKTTS SAYSYTLERH VCLGYVHNFS EDSGEEQVVT TDFINRGEYE
     IDIAGHRFQA KAKLYPVTSF FTHKRRKDDV ELSDFHGK