ASR1_YEAST
ID ASR1_YEAST Reviewed; 288 AA.
AC Q06834; D6W492;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Alcohol-sensitive RING finger protein 1;
GN Name=ASR1; OrderedLocusNames=YPR093C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=15117954; DOI=10.1074/jbc.m401595200;
RA Betz C., Schlenstedt G., Bailer S.M.;
RT "Asr1p, a novel yeast ring/PHD finger protein, signals alcohol stress to
RT the nucleus.";
RL J. Biol. Chem. 279:28174-28181(2004).
CC -!- FUNCTION: Required for tolerance to alcohol.
CC {ECO:0000269|PubMed:15117954}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15117954}. Nucleus
CC {ECO:0000269|PubMed:15117954}. Note=Predominantly cytoplasmic.
CC Accumulates in the nucleus specifically upon alcohol stress. Shuttles
CC between the nucleus and the cytoplasm in a XPO1-dependent manner.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB68139.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U51033; AAB68139.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006949; DAA11508.1; -; Genomic_DNA.
DR PIR; S69076; S69076.
DR RefSeq; NP_015418.2; NM_001184190.1.
DR AlphaFoldDB; Q06834; -.
DR BioGRID; 36261; 110.
DR DIP; DIP-6628N; -.
DR IntAct; Q06834; 27.
DR MINT; Q06834; -.
DR STRING; 4932.YPR093C; -.
DR iPTMnet; Q06834; -.
DR PaxDb; Q06834; -.
DR PRIDE; Q06834; -.
DR EnsemblFungi; YPR093C_mRNA; YPR093C; YPR093C.
DR GeneID; 856208; -.
DR KEGG; sce:YPR093C; -.
DR SGD; S000006297; ASR1.
DR VEuPathDB; FungiDB:YPR093C; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_071677_0_0_1; -.
DR InParanoid; Q06834; -.
DR OMA; ESINECC; -.
DR BioCyc; YEAST:G3O-34234-MON; -.
DR PRO; PR:Q06834; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06834; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:SGD.
DR GO; GO:0016567; P:protein ubiquitination; IDA:SGD.
DR GO; GO:0045471; P:response to ethanol; IMP:SGD.
DR GO; GO:0000921; P:septin ring assembly; IMP:SGD.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..288
FT /note="Alcohol-sensitive RING finger protein 1"
FT /id="PRO_0000055760"
FT ZN_FING 4..48
FT /note="RING-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 121..168
FT /note="RING-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 288 AA; 33347 MW; 331803D72421E6ED CRC64;
MEECPICLAD DQEGEQFGCL NVCGHKFHLN CIREWHKYSI NLKCPICRVE STHLEVGEGQ
HALSINLKMG FMIKNAIDYV GAETTNERNE DDTGEQDQEI EFLSERLRGT LVMDTIKIIQ
CSICGDTDVS RLSLYCQDCE AIYHETCLRG LACEVGDRNT WQECTDCRSN ALLELRMGAI
SSQLASYDSR NSMIFAGELR DKHSVKTQQM YEQIRNAKHK IQMHVRRALD RYPLPLLRFK
DAYKHVNKQV SRKLYRLSDN KYLPDQYDYD SLARTGVHTE LLIYCHDE
