ID   PDR2_NICPL              Reviewed;        1461 AA.
AC   Q2PCF1;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Pleiotropic drug resistance protein 2;
DE   AltName: Full=NpPDR2;
GN   Name=PDR2;
OS   Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4092;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   TISSUE=Flower;
RX   PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA   Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT   "Organization and function of the plant pleiotropic drug resistance ABC
RT   transporter family.";
RL   FEBS Lett. 580:1123-1130(2006).
CC   -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR   EMBL; AJ831424; CAH40786.1; -; mRNA.
DR   AlphaFoldDB; Q2PCF1; -.
DR   SMR; Q2PCF1; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   CDD; cd03233; ABCG_PDR_domain1; 1.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR029481; ABC_trans_N.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR043926; ABCG_dom.
DR   InterPro; IPR034001; ABCG_PDR_1.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013581; PDR_assoc.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF19055; ABC2_membrane_7; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF14510; ABC_trans_N; 1.
DR   Pfam; PF08370; PDR_assoc; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1461
FT                   /note="Pleiotropic drug resistance protein 2"
FT                   /id="PRO_0000234654"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        577..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        622..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        660..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        685..705
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        771..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1203..1223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1243..1263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1291..1311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1321..1341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1348..1368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1379..1399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1430..1450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          172..445
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          523..736
FT                   /note="ABC transmembrane type-2 1"
FT   DOMAIN          859..1111
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          1184..1398
FT                   /note="ABC transmembrane type-2 2"
FT   BINDING         205..212
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         904..911
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1461 AA;  166354 MW;  B6CAB068834532D8 CRC64;
     MEESFLGDEL TRLRSNSRMS SWRSSQSIRE VFGGSSDVFM KNYSTRWREM AEEEEKELKW
     AAIDRLPTYN RLRKGMMKEV MSNGRVVHHE VDMTKLGNQD KKVLMESILK VVEDDNEQFL
     RRLRNRTDRV GIEIPKIEVR FQNLSVGGDA YVGTRALPTL LNSTLNTIEA VLGLIHLSPS
     KKRVVKILED VSGIIRPSRM TLLLGPPGSG KTTFLKALAG KSEKDLRVNG KITYCGHEFH
     EFVPQRTSAY ISQHDLHHGE MTVRETLDFA GRCLGVGTRY DLLVELSRRE KEAGIMPDPQ
     IDAFMKATAI DGQETSLITD YVLKILGLDI CADIMVGDDM RRGISGGQKK RVTTGEMLVG
     PAKAFFMDEI SKGLDSSTTY QIVKFMRQMV HINDITMVIS LLQPAPETFD LFDDVIVLSE
     GQIVYQGPRE NVLEFFEYMG FRCPERKAIA DFLLEVTSKK DQEQYWFRKS RPYVYISVPE
     FSESFNSFQI GEQIIEELTI PYDKYSVHRA ALVKNKYGIS SWELFKSCFT REWLLMKRSS
     FLYIFKTTQI TIMATIALTV FLRTQMKAGT VKDSAKFWGA LFFSLINVMF NGMQELAMTV
     FRLPVFFKQR NSLFYPAWAF ALPIWVLKIP ISLVESAIWI ILTYYTIGFA PAASRFFKQL
     LAFIGVHQMA LSLFRFIAAA GRTQVVANTL GTFTLLMVFI LGGFIVSKDD IQDWMIWGYY
     LSPMMYGQNA IAINEFLDDR WSAPTNGSQP TVGKTLLHAR GLFTTESWYW ISIGALFGFS
     LLFNVLFIAA LTFLNPIGDT KAVKVENGDK NNRRPQETAI VGDIQMAPTR SQANTSSVIP
     FPNNESRKGM ILPFQPLSLA FNHVNYYVDM PAEMKTQGVE EERLQLLRDA SGAFRPGILT
     ALVGVSGAGK TTLMDVLAGR KTGGYIEGSI NISGYPKNQT TFARVSGYCE QNDIHSPYVT
     VYESLLYSAW LRLASDVKTE TRKMFVEEVM ELVELKLLRN ALVGLPGVDG LSTEQRKRLT
     TAVELVANPS IIFMDEPTSG LDARAAAIVM RTVRKTVDTG RTVVCTIHQP SIDIFEAFDE
     LLLMKIGGQV IYAGPLGHRS HKLVEYFETI PGVPKIRESD NPATWMLDVS SSSMEAQLVV
     DFAEVYANSN LYQRNQLLIK ELSTPATCSK DLYFPTQYSQ SFITQCKACF WKQHWSYWRN
     SQYNAIRFFM TVIIGILFGV IFWNKGNQIH RQQDLLNLLG ATYAAVMFLG ATNASAVQSV
     VAIERTVFYR ERAAGMYSEL PYAFAQVAIE TIYVAIQTFV YSLLLFSMIG YQWTAVKFFY
     FYYFIFMCFT YFSMYGMMVV ALTPGYQIAA IVMSFFLSFW NLFSGFLIPR PLIPVWWRWY
     YWASPVAWTI YGIFASQVGD RTDELELTGE TEKIQVNEFL KEYLGYDHDF LLVVVFAHVG
     WVLLFFFVFA YGIKFLNYQK R