PDR3_TOBAC
ID PDR3_TOBAC Reviewed; 1447 AA.
AC Q5W274; Q3BKZ2;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Pleiotropic drug resistance protein 3;
DE AltName: Full=NtPDR3;
GN Name=PDR3;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Bright Yellow 2;
RX PubMed=16337204; DOI=10.1016/j.febslet.2005.11.014;
RA Ducos E., Fraysse A.S., Boutry M.;
RT "NtPDR3, an iron-deficiency inducible ABC transporter in Nicotiana
RT tabacum.";
RL FEBS Lett. 579:6791-6795(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16506311; DOI=10.1016/j.febslet.2005.12.043;
RA Crouzet J., Trombik T., Fraysse A.S., Boutry M.;
RT "Organization and function of the plant pleiotropic drug resistance ABC
RT transporter family.";
RL FEBS Lett. 580:1123-1130(2006).
CC -!- FUNCTION: May be a general defense protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- INDUCTION: By iron deficiency, methyl jasmonate (MeJA), salicylic acid
CC (SA), 1-naphthalene acetic acid (1-NAA), ethanol, and cembrene, a
CC macrocyclic diterpene.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000305}.
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DR EMBL; AJ831379; CAH39853.1; -; mRNA.
DR EMBL; AM050393; CAJ19055.1; -; Genomic_DNA.
DR RefSeq; XP_016438065.1; XM_016582579.1.
DR RefSeq; XP_016492566.1; XM_016637080.1.
DR AlphaFoldDB; Q5W274; -.
DR SMR; Q5W274; -.
DR STRING; 4097.Q5W274; -.
DR PRIDE; Q5W274; -.
DR GeneID; 107764055; -.
DR GeneID; 107812050; -.
DR KEGG; nta:107764055; -.
DR KEGG; nta:107812050; -.
DR OMA; FICYMIL; -.
DR OrthoDB; 324553at2759; -.
DR PhylomeDB; Q5W274; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013581; PDR_assoc.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF08370; PDR_assoc; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1447
FT /note="Pleiotropic drug resistance protein 3"
FT /id="PRO_0000234656"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 575..595
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 659..679
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 685..705
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 769..789
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1191..1211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1222..1242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1272..1292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1306..1326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1336..1356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1364..1384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1419..1439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 173..445
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 523..735
FT /note="ABC transmembrane type-2 1"
FT DOMAIN 847..1099
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1172..1386
FT /note="ABC transmembrane type-2 2"
FT BINDING 205..212
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 892..899
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1447 AA; 163331 MW; 4B3939CBF57A024C CRC64;
MAQLVGSDEI ESFRMDLAEI GRSLRSSFRG QSSSFRSNSA LSASQKDDAV DEENMLAWAA
IERLPTFDRL RSSLFEEING NDANVKRKRV TDVTKLGALE RHVFIEKMIK HIEHDNLQLL
HKIRKRIDKV GVELPTVEVR YKNLTIEAEC ELVHGKPLPT LWNSLKSITM NLARLPGLQS
ELAKIKILND VSGVIKPGRM TLLLGPPGCG KTSLLKALSG NLDKSLKVSG EISYNGYKLE
EFVPQKTSAY VSQNDLHIPE MTVRETLDYS SRFQGVGSRA EIMTDLSRRE KEAGVVPDPD
IDTYMKAISI EGQKKNLQTD YILKILGLDI CADTLVGDAM RRGISGGQKK RLTTGELIVG
PIKALFMDEI SNGLDSSTTY QIVACLQQLA HITDATILVS LLQPAPETFD LFDDIILMAE
GKILYHGPRN SALEFFESCG FKCPERKGVA DFLQEVTSKK DQAQYWHGTK ETYKFVSVDM
LSRKFKESPY RKKLNEELSV PYDNSRSHRN SITFRDYSLP KWELFRACMS REFLLMKRNS
FIYIFKTVQL AIIASITMTV FLRTRMDTDL VHANYYLGAL FYALIILLVD GFPELSMTIT
RLAVFYKQSE LCFYPAWAYT IPATILKIPL SLLESVIWAS MTYYVIGFSP EAGRFFRQLL
LLFAVHMTSI SMFRFLASVC RTIVASTAAG GLSILFVLCF SGFIIPRPSM PIWLKWGFWI
SPLTYGEIGL AVNEFLAPRW QKTLPTNTSI GNEVLESRGL NFDGYFYWIS VCALFGFTIL
FNIGFTLALT FLKAPGSRAI ISTDKYSQIE GSSDSIDKAD AAENSKATMD SHERAGRMVL
PFEPLSLVFQ DVQYYVDTPA AMTELGFTQK RLQLLSDITG ALRPGILTAL MGVSGAGKTT
LLDVLAGRKT TGYVEGEIKV GGYPKVQETF ARVSGYCEQT DIHSPQITVE ESVIFSAWLR
LHPQIDSKTK YEFVKEVIET IELDGIKGML VGMPGVSGLS TEQRKRLTIA VELVANPSII
FMDEPTTGLD ARSAAIVMRA VKNVADTGRT IVCTIHQPSI DIFEAFDELI LLKTGGRMIY
WGHLGRNSCK MIEYFEGISC VPKIKNNHNP ATWMLEVTST SSEADISIDF AEVYKNSALH
KNNEELVKKL SFPPAGSKDL HFPTRFSQNG WGQFKTCFWK QYWSYWRSPS YNLMRSLHML
FASLVSGLLF WDKGKKLDNQ QSVFSVFGAM FTAVIFCGIN NSSSVLPYVT TERSVLYRER
FAGMYASWAY ALAQVAIEIP YLLAQALAFT VITYPMIGYY WSAYKVFWYF YSMFCTLLYF
TYLGMMLVSM TPSFPVAAIL QSSFYTMFNL FAGFLMPKAQ IPKWWIWFYY LTPTSWTLNG
MLTSQYGDIE KEITVFQEKK TVAAFLGDYF GFHHNQLPIV AFVLIAYPLV FASLFAFFIG
KLNFQRR
