PDR3_YEAST
ID PDR3_YEAST Reviewed; 976 AA.
AC P33200; D6VPZ5; E9P920;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Transcription factor PDR3;
DE AltName: Full=Pleiotropic drug resistance protein 3;
GN Name=PDR3; OrderedLocusNames=YBL005W; ORFNames=YBL0323;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8078477; DOI=10.1007/bf00583901;
RA Delaveau T., Delahodde A., Carvajal E., Subik J., Jacq C.;
RT "PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the
RT multidrug resistance phenomenon.";
RL Mol. Gen. Genet. 244:501-511(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-191.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1441753; DOI=10.1002/yea.320080909;
RA Delaveau T., Jacq C., Perea J.;
RT "Sequence of a 12.7 kb segment of yeast chromosome II identifies a PDR-like
RT gene and several new open reading frames.";
RL Yeast 8:761-768(1992).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: PDR1 and PDR3 jointly control the transcription level of both
CC SNQ2 and PDR5.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 166 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X79803; CAA56198.1; -; Genomic_DNA.
DR EMBL; Z35766; CAA84822.1; -; Genomic_DNA.
DR EMBL; AY693124; AAT93143.1; -; Genomic_DNA.
DR EMBL; S47695; AAB23986.2; -; Genomic_DNA.
DR EMBL; BK006936; DAA07115.1; -; Genomic_DNA.
DR PIR; S45738; S45738.
DR RefSeq; NP_009548.1; NM_001178245.1.
DR AlphaFoldDB; P33200; -.
DR SMR; P33200; -.
DR BioGRID; 32694; 106.
DR DIP; DIP-793N; -.
DR IntAct; P33200; 4.
DR MINT; P33200; -.
DR STRING; 4932.YBL005W; -.
DR iPTMnet; P33200; -.
DR MaxQB; P33200; -.
DR PaxDb; P33200; -.
DR PRIDE; P33200; -.
DR TopDownProteomics; P33200; -.
DR EnsemblFungi; YBL005W_mRNA; YBL005W; YBL005W.
DR GeneID; 852278; -.
DR KEGG; sce:YBL005W; -.
DR SGD; S000000101; PDR3.
DR VEuPathDB; FungiDB:YBL005W; -.
DR eggNOG; ENOG502QV4Q; Eukaryota.
DR GeneTree; ENSGT00940000176364; -.
DR HOGENOM; CLU_304446_0_0_1; -.
DR InParanoid; P33200; -.
DR OMA; CAAYQCE; -.
DR BioCyc; YEAST:G3O-28911-MON; -.
DR PRO; PR:P33200; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P33200; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:SGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:2001040; P:positive regulation of cellular response to drug; IMP:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..976
FT /note="Transcription factor PDR3"
FT /id="PRO_0000114962"
FT DNA_BIND 15..41
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 104..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 355
FT /note="I -> V (in Ref. 4; AAT93143)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 976 AA; 112571 MW; B7601269D01DF663 CRC64;
MKVKKSTRSK VSTACVNCRK RKIKCTGKYP CTNCISYDCT CVFLKKHLPQ KEDSSQSLPT
TAVAPPSSHA NVEASADVQH LDTAIKLDNQ YYFKLMNDLI QTPVSPSATH APDTSNNPTN
DNNILFKDDS KYQNQLVTYQ NILTNLYALP PCDDTQLLID KTKSQLNNLI NSWNPEINYP
KLSSFSPRPQ RSIETYLLTN KYRNKIHMTR FSFWTDQMVK SQSPDSFLAT TPLVDEVFGL
FSPIQAFSLR GIGYLIKKNI ENTGSSMLID TKETIYLILR LFDLCYEHLI QGCISISNPL
ENYLQKIKQT PTTTASASLP TSPAPLSNDL VISVIHQLPQ PFIQSITGFT TTQLIENLHD
SFSMFRIVTQ MYAQHRKRFA EFLNQAFSLP HQEKSVLFSS FCSSEYLLST LCYAYYNVTL
YHMLDINTLD YLEILVSLLE IQNEIDERFG FEKMLEVAVT CSTKMGLSRW EYYVGIDENT
AERRRKIWWK IYSLEKRFLT DLGDLSLINE HQMNCLLPKD FRDMGFINHK EFLTKIGTSS
LSPSSPKLKN LSLSRLIEYG ELAIAQIVGD FFSETLYNEK FTSLEVSVKP TIIRQKLLEK
VFEDIESFRL KLAKIKLHTS RVFQVAHCKY PEYPKNDLIE AAKFVSYHKN TWFSILGAVN
NLIARLSEDP EVITEQSMKY ANEMFQEWRE INQFLIQVDT DFIVWACLDF YELIFFVMAS
KFYVEDPHIT LEDVINTLKV FKRITNIISF FNNNLDEKDY DCQTFREFSR SSSLVAISIR
IIFLKYCYAE QIDRAEFIER LKEVEPGLSD LLREFFDTRS FIYRYMLKSV EKSGFHLIIR
KMLESDYKFL YRDKLATGNI PDQGNSSQIS QLYDSTAPSY NNASASAANS PLKLSSLLNS
GEESYTQDAS ENVPCNLRHQ DRSLQQTKRQ HSAPSQISAN ENNIYNLGTL EEFVSSGDLT
DLYHTLWNDN TSYPFL
