PDR8_YEAST
ID PDR8_YEAST Reviewed; 701 AA.
AC Q06149; D6VYR4;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Transcription factor PDR8;
DE AltName: Full=Pleiotropic drug resistance protein 8;
GN Name=PDR8; OrderedLocusNames=YLR266C; ORFNames=L8479.13;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=12529331; DOI=10.1074/jbc.m208549200;
RA Hikkel I., Lucau-Danila A., Delaveau T., Marc P., Devaux F., Jacq C.;
RT "A general strategy to uncover transcription factor properties identifies a
RT new regulator of drug resistance in yeast.";
RL J. Biol. Chem. 278:11427-11432(2003).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
CC -!- FUNCTION: Up-regulates the transcription of the genes for ATP-binding
CC cassette (ABC) transporters YOR1 and PDR15, for major facilitator
CC superfamily transporter AZR1, for pleiotropic drug resistance SNG1, for
CC alpha-glucosidase YJL216C and for YLL056C.
CC {ECO:0000269|PubMed:12529331}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00227, ECO:0000269|PubMed:14562095}.
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DR EMBL; U17244; AAB67383.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09580.1; -; Genomic_DNA.
DR PIR; S51403; S51403.
DR RefSeq; NP_013368.1; NM_001182153.1.
DR AlphaFoldDB; Q06149; -.
DR BioGRID; 31534; 116.
DR DIP; DIP-1571N; -.
DR IntAct; Q06149; 2.
DR MINT; Q06149; -.
DR STRING; 4932.YLR266C; -.
DR PaxDb; Q06149; -.
DR PRIDE; Q06149; -.
DR EnsemblFungi; YLR266C_mRNA; YLR266C; YLR266C.
DR GeneID; 850971; -.
DR KEGG; sce:YLR266C; -.
DR SGD; S000004256; PDR8.
DR VEuPathDB; FungiDB:YLR266C; -.
DR eggNOG; ENOG502R710; Eukaryota.
DR HOGENOM; CLU_010594_1_0_1; -.
DR InParanoid; Q06149; -.
DR OMA; WYLNESE; -.
DR BioCyc; YEAST:G3O-32366-MON; -.
DR PRO; PR:Q06149; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06149; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:SGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc.
FT CHAIN 1..701
FT /note="Transcription factor PDR8"
FT /id="PRO_0000114963"
FT DNA_BIND 31..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 81274 MW; 78C8A82BDFD65F0E CRC64;
MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ CVIRKLPQCV
YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN NAKPVYCRSS ENPLRSLRTS
VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE FQNLWKVLKP LPECTKSQLN ENDVVADLPS
FPQMESCIKS FFAGPLFGIL HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN
LGIVLQILCL GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD
GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL FLDVSTSYDI
GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV SRFTTREIHK REMNEKLTTF
SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF DILILSRSLS IVASIYNIEM IIAQQSRIID
KNRMVQFLLI SISVCVNTMV FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA
FNRLIFREKA FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI
IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK IWLKKGINME
HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD L
