ID   PDRG1_MOUSE             Reviewed;         133 AA.
AC   P59048;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=p53 and DNA damage-regulated protein 1;
GN   Name=Pdrg1; Synonyms=Pdrg;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=14562055; DOI=10.1038/sj.onc.1207010;
RA   Luo X., Huang Y., Sheikh M.S.;
RT   "Cloning and characterization of a novel gene PDRG that is differentially
RT   regulated by p53 and ultraviolet radiation.";
RL   Oncogene 22:7247-7257(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in chaperone-mediated protein folding.
CC       {ECO:0000305}.
CC   -!- SUBUNIT: Component of the PAQosome complex which is responsible for the
CC       biogenesis of several protein complexes and which consists of R2TP
CC       complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members
CC       PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and
CC       DNAAF10/WDR92. {ECO:0000250|UniProtKB:Q9NUG6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the prefoldin subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AY286302; AAP45330.1; -; mRNA.
DR   EMBL; BC031699; AAH31699.1; -; mRNA.
DR   CCDS; CCDS16904.1; -.
DR   RefSeq; NP_849270.1; NM_178939.2.
DR   AlphaFoldDB; P59048; -.
DR   SMR; P59048; -.
DR   BioGRID; 212927; 4.
DR   IntAct; P59048; 2.
DR   MINT; P59048; -.
DR   STRING; 10090.ENSMUSP00000028972; -.
DR   iPTMnet; P59048; -.
DR   PhosphoSitePlus; P59048; -.
DR   EPD; P59048; -.
DR   PaxDb; P59048; -.
DR   PeptideAtlas; P59048; -.
DR   PRIDE; P59048; -.
DR   ProteomicsDB; 287906; -.
DR   Antibodypedia; 25293; 210 antibodies from 26 providers.
DR   Ensembl; ENSMUST00000028972; ENSMUSP00000028972; ENSMUSG00000027472.
DR   GeneID; 68559; -.
DR   KEGG; mmu:68559; -.
DR   UCSC; uc008ngz.1; mouse.
DR   CTD; 81572; -.
DR   MGI; MGI:1915809; Pdrg1.
DR   VEuPathDB; HostDB:ENSMUSG00000027472; -.
DR   eggNOG; ENOG502S6V9; Eukaryota.
DR   GeneTree; ENSGT00390000013253; -.
DR   HOGENOM; CLU_132161_0_0_1; -.
DR   InParanoid; P59048; -.
DR   OMA; RQKCREA; -.
DR   OrthoDB; 1630799at2759; -.
DR   PhylomeDB; P59048; -.
DR   TreeFam; TF329240; -.
DR   BioGRID-ORCS; 68559; 20 hits in 75 CRISPR screens.
DR   ChiTaRS; Pdrg1; mouse.
DR   PRO; PR:P59048; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P59048; protein.
DR   Bgee; ENSMUSG00000027472; Expressed in epithelium of lens and 258 other tissues.
DR   ExpressionAtlas; P59048; baseline and differential.
DR   Genevisible; P59048; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016272; C:prefoldin complex; IEA:InterPro.
DR   GO; GO:1990062; C:RPAP3/R2TP/prefoldin-like complex; ISO:MGI.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   InterPro; IPR030482; PDRG1.
DR   InterPro; IPR002777; PFD_beta-like.
DR   PANTHER; PTHR21162; PTHR21162; 1.
DR   Pfam; PF01920; Prefoldin_2; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..133
FT                   /note="p53 and DNA damage-regulated protein 1"
FT                   /id="PRO_0000058278"
SQ   SEQUENCE   133 AA;  15382 MW;  9CC5E82C14556E72 CRC64;
     MLSPEAERVL RYLVEVEELA EAVLSDKRQI VDLDTKRNQN REGLRALQKD LSVSEDVMVC
     FGNMFIKMPH PKTKEMIQKD QEHLDKEIER LRSQLKVKVN RLFEAQGKPE LKGFNLNPLS
     PDEVKALKVI LKG