ASRA_SALTY
ID ASRA_SALTY Reviewed; 347 AA.
AC P26474;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Anaerobic sulfite reductase subunit A;
DE AltName: Full=Anaerobic sulfite reductase iron-sulfur subunit;
GN Name=asrA; OrderedLocusNames=STM2548;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EB303;
RX PubMed=1704886; DOI=10.1128/jb.173.4.1544-1553.1991;
RA Huang C.J., Barrett E.L.;
RT "Sequence analysis and expression of the Salmonella typhimurium asr operon
RT encoding production of hydrogen sulfide from sulfite.";
RL J. Bacteriol. 173:1544-1553(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Electron transfer protein for anaerobic sulfite reductase
CC subunit A.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Note=Binds 2 [4Fe-4S] clusters.;
CC -!- PATHWAY: Sulfur metabolism; sulfite reduction.
CC -!- SUBUNIT: The anaerobic sulfite reductase seems to consist of three
CC subunits.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: By sulfite. Repressed by oxygen.
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DR EMBL; M57706; AAA99275.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL21442.1; -; Genomic_DNA.
DR PIR; A38453; A38453.
DR RefSeq; NP_461483.1; NC_003197.2.
DR RefSeq; WP_000985204.1; NC_003197.2.
DR AlphaFoldDB; P26474; -.
DR STRING; 99287.STM2548; -.
DR PaxDb; P26474; -.
DR EnsemblBacteria; AAL21442; AAL21442; STM2548.
DR GeneID; 1254070; -.
DR KEGG; stm:STM2548; -.
DR PATRIC; fig|99287.12.peg.2688; -.
DR HOGENOM; CLU_046702_0_1_6; -.
DR OMA; THKLGTW; -.
DR PhylomeDB; P26474; -.
DR BioCyc; MetaCyc:MON-12544; -.
DR BioCyc; SENT99287:STM2548-MON; -.
DR UniPathway; UPA00370; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1060.10; -; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR014259; Sulphite_reductase_A.
DR Pfam; PF17179; Fer4_22; 1.
DR TIGRFAMs; TIGR02910; sulfite_red_A; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 2: Evidence at transcript level;
KW 4Fe-4S; Cytoplasm; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..347
FT /note="Anaerobic sulfite reductase subunit A"
FT /id="PRO_0000159257"
FT DOMAIN 219..251
FT /note="4Fe-4S ferredoxin-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT DOMAIN 302..331
FT /note="4Fe-4S ferredoxin-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00711"
FT BINDING 230
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 233
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 236
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 240
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 312
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 315
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 318
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 322
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 347 AA; 39680 MW; 45B2C5DAEBF14296 CRC64;
MAIKITPDEF SLLIQRLNKK WRVFAPSAEF RGGRFSDTDN IIYQRISGWR DLIWHEKSHM
SPNTIIAPIT ETLFYFDKDT IQIAETDTSP IIIFARACDI NAMSRLDYMY LSNGNNSDYS
YQLLREHIRF VLIECEESFE NCFCVSMGTN KTDCYSAAMR FSDEGALVSI RDPFIEAAIQ
GLGQEADYTP SFVSENRETV VTPDSVCHDP QKIRDILTHH PLWDAYDSRC ISCGRCTTGC
PTCTCYSVFD VAYDENPQRG ERRRQWASCM VPGFSDMAGG HGFREKPGER LRYRALHKVN
DYKARNGIEH MCVGCGRCDD RCPQYIKFSL IINKMTAAVR QALAEEA
