PDS5A_DANRE
ID PDS5A_DANRE Reviewed; 1320 AA.
AC A1L1F4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Sister chromatid cohesion protein PDS5 homolog A;
GN Name=pds5a {ECO:0000250|UniProtKB:Q29RF7}; ORFNames=zgc:66331;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAI29036.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate sister chromatid cohesion during mitosis and
CC couple it to DNA replication. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the cohesin complex. Binds chromatin in a
CC cohesin-dependent manner (By similarity).
CC {ECO:0000250|UniProtKB:Q29RF7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q29RF7}.
CC -!- SIMILARITY: Belongs to the PDS5 family. {ECO:0000305}.
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DR EMBL; BC129035; AAI29036.1; -; mRNA.
DR RefSeq; NP_957286.2; NM_200992.2.
DR AlphaFoldDB; A1L1F4; -.
DR SMR; A1L1F4; -.
DR STRING; 7955.ENSDARP00000109877; -.
DR PaxDb; A1L1F4; -.
DR PeptideAtlas; A1L1F4; -.
DR PRIDE; A1L1F4; -.
DR GeneID; 393967; -.
DR KEGG; dre:393967; -.
DR CTD; 23244; -.
DR ZFIN; ZDB-GENE-040426-1612; pds5a.
DR eggNOG; KOG1525; Eukaryota.
DR InParanoid; A1L1F4; -.
DR OrthoDB; 69768at2759; -.
DR PhylomeDB; A1L1F4; -.
DR Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR Reactome; R-DRE-2468052; Establishment of Sister Chromatid Cohesion.
DR Reactome; R-DRE-2470946; Cohesin Loading onto Chromatin.
DR Reactome; R-DRE-2500257; Resolution of Sister Chromatid Cohesion.
DR PRO; PR:A1L1F4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; IBA:GO_Central.
DR GO; GO:0008156; P:negative regulation of DNA replication; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039776; Pds5.
DR PANTHER; PTHR12663; PTHR12663; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1320
FT /note="Sister chromatid cohesion protein PDS5 homolog A"
FT /id="PRO_0000296345"
FT REPEAT 156..195
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 272..310
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 388..426
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 709..747
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 990..1028
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REGION 1158..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1158..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1224..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1320 AA; 148958 MW; B5FB528659C4129E CRC64;
MEFPQQPQQQ RPAGDGKITY PLGVKEITDK ISNDEVVKRL KLVVKTYMDM DQDSEEEKQQ
YLALALHLAS EFFLRNPNKD VRLLVACCLA DIFRIYAPEA PYTSHDKLKE IFLFITRQLK
GLEDTKSPQF NRYFYLLENL AWVKSYNICF ELEDCNEIFI QLFKTLFSVI NNSHNQKVQM
HMLDLMSSII MEGDGVTQEL LDTILINLIP AHKNLNKQAY DLARTLLKRT VQTIETCIAS
FFNQVLVMGK SSVSDLSEHV FDLIQELFAI DPLLLVSVMP QLEFKLKSND GEERLAVVKL
LAKLFGAKDS ELATQNRPLW QCFLGRFNDI HVPVRLECVK FASHCLMNHP DLAKDLTEFL
KVRSHDPEEA IRHDVIVTII NAGKKDLNLV NDQLLGFVRE RMLDKRWRVR KEAMMGLAQL
FKKYCLHHEA GKESALKISW IKDKLLHIYY QNSIDDKLLV EKIFAQYMVP HSLETEEKMK
CLYYLYACLD TNAVKALNEM WKCQNMLRGL VRELLDLHKL PTSEANTSAM FGKLMTIAKN
LPDPGKAQDF MKKFNQVLGE DEKLRLQLEQ LISPTCSCKQ AEQCVREITR KLTFPKQPTN
PFLEMVKFLL ERIAPVHIDS EAISALVKLL NKSIEGTADD EDEGVTPDTA IRAGLELLKV
LSFTHPTAFH SAETYESLLQ CLKMEDDKVA EAAIQIFRNT GQKIETELPQ IRSTLIPILH
QKAKRGTPHQ AKQAVHCIHA IFHNKEVQLA QIFEPLSRSL NADVPEQLIT PLVSLGHISM
LAPDQFASPM KSIVANFIVK DLLMNDRSVG NKNGRLWTAD DEVSPEVLAK VQAIKLLVRW
LLGMKNNQSK SANSTLRLPS AMLVSEGDLT EQKKISKSDM SRLRLAAGSA ILKLAQEPCY
HDIITPEQFQ LCGLVINDEC YQVRQIYAQK LHVALVKLLL PLEYMAVFAL CAKDPVKERR
AHARQCLLKN ISVRREYIKQ NPMAHEKLLS LLPEYVVPYM IHLLAHDPDL TKPQDLEQLR
DVKECLWFML EVLMTKNENN SHSFLRKMVE NIKQTKDAQC PDDPKANEKL YIVCDVALFV
IANKSTSCHL DSPKDPVLPS KFYTPPDKEF VNDKEYLSAE AKIVLQTGKI QQPPKQTGVL
GAVNKPLTVT ARRPYIKTFT SETGSNASTN SQPSSPATNK SRDVSSEVGA RENEENPVIT
KAVSVKKEEA AQPSGRKRAA PASDGTENSV SSNPSAGSQP PLNKPRRGRP PKNSAGAATQ
EKEAGATTGA GAGRGRKRAA PSQDPSSTAS TDALSDKTPK QQKEAEPKRA APQRQIDLQR