PDS5B_ARATH
ID PDS5B_ARATH Reviewed; 1410 AA.
AC F4I735; Q9CAP7;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Sister chromatid cohesion protein PDS5 homolog B {ECO:0000305};
DE AltName: Full=Precocious dissociation of sisters protein 5-B {ECO:0000305};
DE Short=AtPDS5B {ECO:0000303|PubMed:26648949};
GN Name=PDS5B {ECO:0000303|PubMed:26648949};
GN OrderedLocusNames=At1g77600 {ECO:0000312|Araport:AT1G77600};
GN ORFNames=T5M16.19 {ECO:0000312|EMBL:AAG51671.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=24946828; DOI=10.1111/tpj.12595;
RA Wilson-Sanchez D., Rubio-Diaz S., Munoz-Viana R., Perez-Perez J.M.,
RA Jover-Gil S., Ponce M.R., Micol J.L.;
RT "Leaf phenomics: a systematic reverse genetic screen for Arabidopsis leaf
RT mutants.";
RL Plant J. 79:878-891(2014).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=26648949; DOI=10.3389/fpls.2015.01034;
RA Pradillo M., Knoll A., Oliver C., Varas J., Corredor E., Puchta H.,
RA Santos J.L.;
RT "Involvement of the cohesin cofactor PDS5 (SPO76) during meiosis and DNA
RT repair in Arabidopsis thaliana.";
RL Front. Plant Sci. 6:1034-1034(2015).
CC -!- FUNCTION: Cohesin cofactor dispensable during the meiotic division but
CC playing an important role in DNA repair by homologous recombination
CC (HR) probably by helping SMC5/SMC6 complex (PubMed:26648949). Regulator
CC of sister chromatid cohesion in mitosis which may stabilize cohesin
CC complex association with chromatin (PubMed:26648949). May couple sister
CC chromatid cohesion during mitosis to DNA replication (By similarity).
CC Cohesion ensures that chromosome partitioning is accurate in both
CC meiotic and mitotic cells and plays an important role in DNA repair
CC (PubMed:26648949). Required for proximal-distal cell cycle-driven leaf
CC growth in both lamina and petiole (PubMed:24946828).
CC {ECO:0000250|UniProtKB:Q29RF7, ECO:0000269|PubMed:24946828,
CC ECO:0000269|PubMed:26648949}.
CC -!- SUBUNIT: Interacts with the cohesin complex.
CC {ECO:0000250|UniProtKB:Q29RF7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- DISRUPTION PHENOTYPE: Weak impact on meiosis such as formation of some
CC chromosome bridges at late anaphase I and telophase I in forming
CC pollen, but severe effects on development, fertility, somatic
CC homologous recombination (HR) and DNA repair, especially in plants
CC lacking PDS5A, PDS5B, PDS5C, PDS5D and PDS5E (PubMed:26648949). Altered
CC two-dimensional leaf shape leading to compact rosettes and roundish
CC leaves due to lower cell number in both the lamina and the petiole
CC explaining the macroscopic reduction in lamina and petiole length
CC (PubMed:24946828). {ECO:0000269|PubMed:24946828,
CC ECO:0000269|PubMed:26648949}.
CC -!- SIMILARITY: Belongs to the PDS5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51671.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC010704; AAG51671.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35998.1; -; Genomic_DNA.
DR PIR; E96805; E96805.
DR RefSeq; NP_001185420.1; NM_001198491.1.
DR SMR; F4I735; -.
DR PRIDE; F4I735; -.
DR ProteomicsDB; 193839; -.
DR EnsemblPlants; AT1G77600.2; AT1G77600.2; AT1G77600.
DR GeneID; 844095; -.
DR Gramene; AT1G77600.2; AT1G77600.2; AT1G77600.
DR KEGG; ath:AT1G77600; -.
DR Araport; AT1G77600; -.
DR HOGENOM; CLU_002325_2_0_1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I735; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IMP:UniProtKB.
DR GO; GO:0006310; P:DNA recombination; IMP:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IMP:UniProtKB.
DR GO; GO:0035825; P:homologous recombination; IMP:UniProtKB.
DR GO; GO:0009965; P:leaf morphogenesis; IMP:UniProtKB.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; IMP:UniProtKB.
DR GO; GO:0009954; P:proximal/distal pattern formation; IMP:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039776; Pds5.
DR PANTHER; PTHR12663; PTHR12663; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Developmental protein; DNA damage; DNA repair;
KW Mitosis; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1410
FT /note="Sister chromatid cohesion protein PDS5 homolog B"
FT /id="PRO_0000453276"
FT REPEAT 3..40
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 58..97
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 104..141
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 154..193
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 196..234
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 290..327
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 334..371
FT /note="HEAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 373..410
FT /note="HEAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 411..448
FT /note="HEAT 9"
FT /evidence="ECO:0000255"
FT REPEAT 488..528
FT /note="HEAT 10"
FT /evidence="ECO:0000255"
FT REPEAT 588..625
FT /note="HEAT 11"
FT /evidence="ECO:0000255"
FT REPEAT 663..700
FT /note="HEAT 12"
FT /evidence="ECO:0000255"
FT REPEAT 714..751
FT /note="HEAT 13"
FT /evidence="ECO:0000255"
FT REPEAT 752..790
FT /note="HEAT 14"
FT /evidence="ECO:0000255"
FT REPEAT 848..885
FT /note="HEAT 15"
FT /evidence="ECO:0000255"
FT REPEAT 916..953
FT /note="HEAT 16"
FT /evidence="ECO:0000255"
FT REPEAT 1121..1154
FT /note="HEAT 17"
FT /evidence="ECO:0000255"
FT REPEAT 1155..1192
FT /note="HEAT 18"
FT /evidence="ECO:0000255"
FT REGION 1348..1410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 543..550
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 847..854
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 1377..1397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1410 AA; 159169 MW; EEB5D0F2DFE8E02D CRC64;
MEKTPTQIVS ELCSRLLQLS RPNKDSLVKL LREVANTLSK IDQPSATNKE KGLKLIEAEL
RPLKKSIIKH ALLKNRDNDV SLLVTVCVSE LFRILAPHLP FEDEYLRDIF TLFIAEFSEL
SDTVSPYFSK RAKILETVSR LKFCLLMLDE DCQDLVHEMF NMFFSLVREH HQQSLINQKS
MKTQQRKANT QQTQHSLFNN ILAIMSDVLE EEANSSFVVV ILENLVKEGE DTTSGADKLA
SSLIERCADR LEPLICSFLT SCFMEKDSIQ TNLKDSYHEI IFKISLIAPQ MLLAVIPKLT
QELLTDQVDV RIKALNLAGR IFAQPKHCLS SYVETYQDLY AEFLRRFSDK SAEVRMAALK
CGKQCYFANP SGNKASGVLT AIQERLLDFD DRVRTQALIV ACDIMKFNMK YVPLNLISEA
SERLRDKKIS VRKKALQKLT EVYQDYCDKC SEGDMTITDN FEQIPCKILL LCCEKNCEEF
RSQNLELVLS DDLFPRLLPV EERMRHWVQC FAIMNHIHLK SLNSILSQKR RLQNELRHCL
TLWRKAKVDN IEEAQRKKKS YFVKLSACFP DASEAEDLFE KLDRMRDASI FDVLTLLLEE
LSSTNAQIIK EKFLKMIGVK HSLFEFLRIL STKCSPSIFS SEHVQCLLNQ LCGSTSANTQ
LKAPSIKLLL VILNMFPSYL RGSEKQFLKL LEENDSAADE LIVVLSKAAP YISVNFGDYY
PVLEKVCLEG TRSQTKCAVS AISSLAGSSE KSVFSELCEM LMDSLLCGRN IPTTLQSLAC
VGQYSVLEYD NIYEDITSYI YRVFQAEPSD NQLPCDQSSG CCNSCKLKIY GLKTLVKSFL
PRHGQVVRKI DDLLNILKKT LKSQGHDGIK SCEDTGANVR LAAAKAVLLL SRKWDLHISP
EVFRLTILMA KDSNAFITKT FLTKLYKLLT EHMIPSRYAC AFSFSLSSPC RDLHDDSFRY
INGFINKATR ESRTCRDLDQ GESLTDSPVY MTVFLIHVLA HDPEFPSEDC RDEHIYARFC
GPLFSVLQVL LSINNNGFTI KETAPFLFCI FRAIKRAEDA VDSRKTPRLH ILADIGYSAV
NILNSIVVTS PQAPRSILLP SSLYSLTSIT DNQNKAKSRT RNALEQSFIE RIVHIFQSQI
SMHDQRCQKD SLAVGSEDKV LPPLLGNQIE TSITGSTEAS QNNTRCSRKR THLGEHISCN
SLSLRTVESE IPIKKLERHT TCAKESVKAS VSNKITSSKH SGVVSALKDI SNHGEAIIGQ
RIKLLSPTDG CFYPGTVEKF NSKSNSHKII FDNGDVELVC LDSESWETLS HESMGQQERL
GKETESYGSR NCVPEISHTL AKVTAQKQTT TTKQQNKKVP AKLNPPAVPC FMMSAKSKKG
NSDSGEGSVS EVTDTSDNIG PRRSRRQRIS
