PDS5B_CHICK
ID PDS5B_CHICK Reviewed; 1412 AA.
AC Q5F3U9;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 3.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Sister chromatid cohesion protein PDS5 homolog B;
DE AltName: Full=Androgen-induced proliferation inhibitor;
GN Name=PDS5B; Synonyms=APRIN; ORFNames=RCJMB04_6g19;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|EMBL:CAH65185.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB {ECO:0000312|EMBL:CAH65185.1};
RC TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAH65185.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Plays a role in androgen-induced proliferative arrest.
CC Required for maintenance of sister chromatid cohesion during mitosis
CC (By similarity). {ECO:0000250|UniProtKB:Q9NTI5}.
CC -!- SUBUNIT: Interacts with the cohesin complex.
CC {ECO:0000250|UniProtKB:Q9NTI5}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6TRW4}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH65185.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ851551; CAH65185.1; ALT_SEQ; mRNA.
DR RefSeq; XP_015133356.1; XM_015277870.1.
DR AlphaFoldDB; Q5F3U9; -.
DR SMR; Q5F3U9; -.
DR STRING; 9031.ENSGALP00000027519; -.
DR PaxDb; Q5F3U9; -.
DR Ensembl; ENSGALT00000027571; ENSGALP00000027519; ENSGALG00000017070.
DR GeneID; 418910; -.
DR CTD; 23047; -.
DR VEuPathDB; HostDB:geneid_418910; -.
DR eggNOG; KOG1525; Eukaryota.
DR GeneTree; ENSGT00940000157257; -.
DR InParanoid; Q5F3U9; -.
DR OrthoDB; 69768at2759; -.
DR PhylomeDB; Q5F3U9; -.
DR Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR Reactome; R-GGA-2468052; Establishment of Sister Chromatid Cohesion.
DR Reactome; R-GGA-2470946; Cohesin Loading onto Chromatin.
DR Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR PRO; PR:Q5F3U9; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000017070; Expressed in testis and 13 other tissues.
DR ExpressionAtlas; Q5F3U9; baseline and differential.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039776; Pds5.
DR PANTHER; PTHR12663; PTHR12663; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1412
FT /note="Sister chromatid cohesion protein PDS5 homolog B"
FT /id="PRO_0000287423"
FT REPEAT 383..419
FT /note="HEAT"
FT /evidence="ECO:0000255"
FT REGION 1137..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 161026 MW; 0B6252EB7BF24743 CRC64;
MAHSKTRAND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA
LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT
KSPQFNRYFY LLENIAWVKS YNICFELEDS NEIFTQLYRT LFSVINNGHN QKVHMHMVDL
MSSIICEGDT VSQELLDTVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV
LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD LTEYLKVRSH
DPEEAIRHDV IVSIVTAAKK DLLLVNDHLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYS
LQSEAGKEAA KQISWIKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET NERMKCLYYL
YATLDSNAVK ALNEMWKCQN LLRHQVKDLV DLIKQPKTDA SSKAIFSKVM VITRNLPDPG
KAQDFMKKFT QVLEDDEKIR SQLEMLVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL ELLKVLSFTH
PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE EDFPHIRSAL LPVLHHKAKK
GPPRQAKYAI HCINAIFSSK ETQFAQIFEP LHKSLDPSNF EHLITPLVTI GHIAMLAPDQ
FAAPLKSLVA TFIVKDLLMN DRLPGKKTTK LWVPDEEVSP ETLVKIQAIK MMVRWLLGMK
NNHSKSGTST LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
LEQYQLCALA INDECYQVRQ IFAQKLHKGL SRLRLPLEYM AICALCAKDP VKERRAHARQ
CLVKNINVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA HDPDYVKVQD IEQLKDIKEC
LWFILEILMA KNENNSHAFI RKMVENIKQT KDAQGPDDAK MNEKLYTVCD VAMNIIMSKS
TTYSLESPKD PVLPARYFTQ PDKNFSNTKN YLPPEMKSFF TPGKPKAANV LGAVNKPLSS
AGKQSQSKSS RMETVSNASS SSNPSSPGRI KGRLDSTEMD HSENEDFTLS SPLPGKKTDK
RDDSDLSELE KPRGRKKPAI TDSEEKLSID DLNKLGQDQK LRGSQRGRKR PAVVSESDET
QWQEEKRLKE DVIESEDEQN SPPKKGRRGR PPKPNNGGTP KEEPAAKSSK RSKKKQTSAA
AVEEEEEEEE RQTENIEQKP KGRQNRSTKR TQQSRAGRSK QAASKENESS EEMDVFQSSS
PVSDDVPQEE VMEEEEVSTI NVRRRTSKRE RR
