ID   PDS5_DICDI              Reviewed;        1450 AA.
AC   Q552Q7;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Sister chromatid cohesion protein PDS5 homolog;
DE   AltName: Full=Precocious dissociation of sisters protein 5 homolog;
GN   Name=pds5 {ECO:0000250|UniProtKB:Q04264}; ORFNames=DDB_G0275929;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May regulate sister chromatid cohesion during mitosis and
CC       couple it to DNA replication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04264}.
CC   -!- SIMILARITY: Belongs to the PDS5 family. {ECO:0000255}.
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DR   EMBL; AAFI02000013; EAL69715.1; -; Genomic_DNA.
DR   RefSeq; XP_643624.1; XM_638532.1.
DR   AlphaFoldDB; Q552Q7; -.
DR   SMR; Q552Q7; -.
DR   STRING; 44689.DDB0305112; -.
DR   PaxDb; Q552Q7; -.
DR   PRIDE; Q552Q7; -.
DR   EnsemblProtists; EAL69715; EAL69715; DDB_G0275929.
DR   GeneID; 8620211; -.
DR   KEGG; ddi:DDB_G0275929; -.
DR   dictyBase; DDB_G0275929; pds5.
DR   eggNOG; KOG1525; Eukaryota.
DR   HOGENOM; CLU_251372_0_0_1; -.
DR   InParanoid; Q552Q7; -.
DR   OMA; CFDIVSG; -.
DR   PhylomeDB; Q552Q7; -.
DR   Reactome; R-DDI-2468052; Establishment of Sister Chromatid Cohesion.
DR   Reactome; R-DDI-2470946; Cohesin Loading onto Chromatin.
DR   Reactome; R-DDI-2500257; Resolution of Sister Chromatid Cohesion.
DR   PRO; PR:Q552Q7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; IBA:GO_Central.
DR   GO; GO:0008156; P:negative regulation of DNA replication; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039776; Pds5.
DR   PANTHER; PTHR12663; PTHR12663; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..1450
FT                   /note="Sister chromatid cohesion protein PDS5 homolog"
FT                   /id="PRO_0000391850"
FT   REGION          1..145
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1340..1450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          650..716
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        26..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1344..1362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1363..1382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1406..1424
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1434..1450
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1450 AA;  166571 MW;  C05E78ABFFE56625 CRC64;
     MATRATRAAS EVAKTKAATN LPSIRKRKSI ENEEEESKHN TSINDDGELD SDIDEEDESK
     FEKEFTVKKR QKKSPAKTQQ QPQKSITTPT KPTPTKTTSK PTKPSATTSP SQQKQSSQSS
     QNTSKKQATS SSSQQSTQQK KKETKIKYNL KPINIERLAT YDQHMSGTLS NEKIIKRLKK
     LDEYLQDKKR GNTEGLEIVL EVLIDPKFAD NKIFEIRLMT SCCLSEIFRI YAPTLPFDMV
     VLKVVFKLFT EQVLQGDKVD KKLFPQYFQM LERLSVIKVF ALLALVDSSM LTPFFKDCLS
     RVHGDKEHQP MDIMFSTLLN TILESLEEVP TSLWNELLES LIEREKGGVP TSKAIFTHDL
     IETNSRFLQV HFDLFLQDLL EPEILAGGQQ QQQQDSSLSN NGISKQLKKK KNEILFEMFN
     ILPEFIYPAL QNLEFDLEDV NASIRKGAAI VLSRCYSTES ASDELIAQRP TLYTTFLNRF
     HDVDIKIRTV MMEFSEHFTT TSDLEMERVL KSVRDRFRDS EPDIRIKAIQ IFQKYIIKNP
     ELMNPELMSE YLERVRDKDS KVRKDAEISL STVWRSVREK YGPIDDWSNT LIDCFSTIPN
     TLIHCLGLYD DDKYRIEIAF DSILLPQHSD VKNRSQVFLE IYKYLDESNK QLFKKYLEEK
     KSLRQEFLAL IQFLKNPKVV GGSTTPTSKK SQPPQQQQQQ QQQQQQQLQQ PENDIEVYIT
     HVDNLLPKFI GESSKKLVRQ LITPSNKKIL DLLVLISDIN TTFQEQYNIK ISIISKAQNE
     SSFSEFIKYM VNKLAYSIVG KENIKYLLRG LRSDLGLDNF DKNNPIDLLE EFNEKIYEKE
     VKDGVPETLE VLLMLSQVYA NIFDDYGDQL VGFLTCSKSI VYPVLQILSN SWKTLKLSKK
     TLKSTLDMLL RLTQVPQPTL ARLAFKTFIK FATPALTSIN STNGKVDNNK LVVTLKDLAN
     NLFDQLEDKS KNLLSILEVI GCLAKGYSLV LSEHLDTLDI LLIKKIMTGV CTLDFNQKVQ
     LNKSVEHHLN TSYSKDVLIK IAAIKCMSNY LLGLREITKK SHEMVNMLFE FYIGLDKNKT
     YNDLEKSHLK IHIAIGLLRV FQRSQYEKEI TPQQFILICN STSITTKQRG DPLIRRLIEK
     LAKVMILNRL PMKYMAAFGM AAQQPYSVLA LVRKHSTSII KTRRMVISRL AASLSMAKNL
     TEFYPESSMP YFLYVVSHRE DFERDAPDYI ESACYLNFFI DLLVEEADNY SIIHTIFTKL
     KRSTDALDKK SKNHIIAAEL GLQILTHQYQ QKKWKPQKHP IVIVLPEKFY IIHDDQDEMS
     IDDEVTSIKL PSLLPKRFKL PPLPSITDQN NNNNNNNTNS TNNDESEKDE NNNNKNDNDN
     DNDNDDNSTT AVPQKSIISK PPAKKVSKKA AAKQKSPKKK TNKKKKQSSS EEEVSSSEEE
     DESQDEEVEN