ID   PDTAR_MYCTU             Reviewed;         205 AA.
AC   P9WGM3; L0T8T8; O06143; Q7D890;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Probable transcriptional regulatory protein PdtaR;
GN   Name=pdtaR; OrderedLocusNames=Rv1626;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, AND PHOSPHORYLATION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16026786; DOI=10.1016/j.febslet.2005.06.043;
RA   Morth J.P., Gosmann S., Nowak E., Tucker P.A.;
RT   "A novel two-component system found in Mycobacterium tuberculosis.";
RL   FEBS Lett. 579:4145-4148(2005).
RN   [3]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS), AND SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15341725; DOI=10.1016/j.str.2004.06.018;
RA   Morth J.P., Feng V., Perry L.J., Svergun D.I., Tucker P.A.;
RT   "The crystal and solution structure of a putative transcriptional
RT   antiterminator from Mycobacterium tuberculosis.";
RL   Structure 12:1595-1605(2004).
CC   -!- FUNCTION: Member of the two-component regulatory system PdtaR/PdtaS.
CC       {ECO:0000269|PubMed:16026786}.
CC   -!- SUBUNIT: Monomer. Dimer; when bound to its cognate DNA (Potential).
CC       {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PdtaS. {ECO:0000269|PubMed:16026786}.
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DR   EMBL; AL123456; CCP44390.1; -; Genomic_DNA.
DR   PIR; H70558; H70558.
DR   RefSeq; NP_216142.1; NC_000962.3.
DR   RefSeq; WP_003408045.1; NZ_NVQJ01000016.1.
DR   PDB; 1S8N; X-ray; 1.48 A; A=1-205.
DR   PDB; 1SD5; X-ray; 1.68 A; A=1-205.
DR   PDBsum; 1S8N; -.
DR   PDBsum; 1SD5; -.
DR   AlphaFoldDB; P9WGM3; -.
DR   SMR; P9WGM3; -.
DR   STRING; 83332.Rv1626; -.
DR   iPTMnet; P9WGM3; -.
DR   PaxDb; P9WGM3; -.
DR   DNASU; 885080; -.
DR   GeneID; 45425595; -.
DR   GeneID; 885080; -.
DR   KEGG; mtu:Rv1626; -.
DR   TubercuList; Rv1626; -.
DR   eggNOG; COG3707; Bacteria.
DR   OMA; QKTSMDR; -.
DR   PhylomeDB; P9WGM3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0043168; F:anion binding; IDA:CAFA.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IDA:MTBBASE.
DR   GO; GO:0031564; P:transcription antitermination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005561; ANTAR.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR008327; Sig_transdc_resp-reg_antiterm.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03861; ANTAR; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PIRSF; PIRSF036382; RR_antiterm; 1.
DR   SMART; SM01012; ANTAR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50921; ANTAR; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription antitermination; Transcription regulation;
KW   Two-component regulatory system.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:21969609"
FT   CHAIN           2..205
FT                   /note="Probable transcriptional regulatory protein PdtaR"
FT                   /id="PRO_0000386597"
FT   DOMAIN          15..129
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          135..196
FT                   /note="ANTAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00308"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0007744|PubMed:21969609"
FT   MOD_RES         65
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          15..19
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           23..35
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          39..46
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           47..57
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          60..67
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          69..71
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           73..82
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          88..93
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           94..96
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           97..101
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           104..106
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          109..115
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           118..141
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   STRAND          142..144
FT                   /evidence="ECO:0007829|PDB:1SD5"
FT   HELIX           145..166
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           170..183
FT                   /evidence="ECO:0007829|PDB:1S8N"
FT   HELIX           188..199
FT                   /evidence="ECO:0007829|PDB:1S8N"
SQ   SEQUENCE   205 AA;  22669 MW;  C57AD16BAD0E3C0B CRC64;
     MTGPTTDADA AVPRRVLIAE DEALIRMDLA EMLREEGYEI VGEAGDGQEA VELAELHKPD
     LVIMDVKMPR RDGIDAASEI ASKRIAPIVV LTAFSQRDLV ERARDAGAMA YLVKPFSISD
     LIPAIELAVS RFREITALEG EVATLSERLE TRKLVERAKG LLQTKHGMTE PDAFKWIQRA
     AMDRRTTMKR VAEVVLETLG TPKDT