ID   PDTAS_MYCTO             Reviewed;         501 AA.
AC   P9WGL4; L0TDI0; O05846; Q7D5W7;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Probable sensor histidine kinase PdtaS;
DE            EC=2.7.13.3;
GN   Name=pdtaS; OrderedLocusNames=MT3316;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system PdtaR/PdtaS.
CC       Autophosphorylates, probably on a histidine residue, and transfers its
CC       phosphate group to PdtaR (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
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DR   EMBL; AE000516; AAK47658.1; -; Genomic_DNA.
DR   PIR; E70596; E70596.
DR   RefSeq; WP_003416886.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGL4; -.
DR   SMR; P9WGL4; -.
DR   EnsemblBacteria; AAK47658; AAK47658; MT3316.
DR   GeneID; 45427213; -.
DR   KEGG; mtc:MT3316; -.
DR   PATRIC; fig|83331.31.peg.3571; -.
DR   HOGENOM; CLU_045351_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.280; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR038424; H_kinase_PdtaS_GAF_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR022066; PdtaS_GAF.
DR   InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR   Pfam; PF12282; H_kinase_N; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07568; HisKA_2; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Transferase;
KW   Two-component regulatory system.
FT   CHAIN           1..501
FT                   /note="Probable sensor histidine kinase PdtaS"
FT                   /id="PRO_0000428341"
FT   DOMAIN          300..495
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   MOD_RES         303
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   501 AA;  54012 MW;  DF099B268388AD00 CRC64;
     MSTLGDLLAE HTVLPGSAVD HLHAVVGEWQ LLADLSFADY LMWVRRDDGV LVCVAQCRPN
     TGPTVVHTDA VGTVVAANSM PLVAATFSGG VPGREGAVGQ QNSCQHDGHS VEVSPVRFGD
     QVVAVLTRHQ PELAARRRSG HLETAYRLCA TDLLRMLAEG TFPDAGDVAM SRSSPRAGDG
     FIRLDVDGVV SYASPNALSA YHRMGLTTEL EGVNLIDATR PLISDPFEAH EVDEHVQDLL
     AGDGKGMRME VDAGGATVLL RTLPLVVAGR NVGAAILIRD VTEVKRRDRA LISKDATIRE
     IHHRVKNNLQ TVAALLRLQA RRTSNAEGRE ALIESVRRVS SIALVHDALS MSVDEQVNLD
     EVIDRILPIM NDVASVDRPI RINRVGDLGV LDSDRATALI MVITELVQNA IEHAFDPAAA
     EGSVTIRAER SARWLDVVVH DDGLGLPQGF SLEKSDSLGL QIVRTLVSAE LDGSLGMRDA
     RERGTDVVLR VPVGRRGRLM L