ID   PDUM_CITFR              Reviewed;         163 AA.
AC   B1VB72;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Bacterial microcompartment assembly protein PduM {ECO:0000250|UniProtKB:Q9XDN4};
DE   AltName: Full=Propanediol utilization protein PduM;
GN   Name=pduM {ECO:0000303|PubMed:18332146};
OS   Citrobacter freundii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter; Citrobacter freundii complex.
OX   NCBI_TaxID=546;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RX   PubMed=18332146; DOI=10.1074/jbc.m709214200;
RA   Parsons J.B., Dinesh S.D., Deery E., Leech H.K., Brindley A.A., Heldt D.,
RA   Frank S., Smales C.M., Lunsdorf H., Rambach A., Gass M.H., Bleloch A.,
RA   McClean K.J., Munro A.W., Rigby S.E.J., Warren M.J., Prentice M.B.;
RT   "Biochemical and Structural Insights into Bacterial Organelle Form and
RT   Biogenesis.";
RL   J. Biol. Chem. 283:14366-14375(2008).
RN   [2]
RP   FUNCTION, AND INTERACTION WITH PDUK.
RX   PubMed=20417607; DOI=10.1016/j.molcel.2010.04.008;
RA   Parsons J.B., Frank S., Bhella D., Liang M., Prentice M.B., Mulvihill D.P.,
RA   Warren M.J.;
RT   "Synthesis of empty bacterial microcompartments, directed organelle protein
RT   incorporation, and evidence of filament-associated organelle movement.";
RL   Mol. Cell 38:305-315(2010).
CC   -!- FUNCTION: Plays an essential role in assembly and/or stability of the
CC       bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD)
CC       degradation. {ECO:0000250|UniProtKB:Q9XDN4}.
CC   -!- FUNCTION: Expression of a cosmid containing the full 21-gene pdu operon
CC       in E.coli allows E.coli to grow on 1,2-propanediol (1,2-PD) with the
CC       appearance of bacterial microcompartments (BMC) in its cytoplasm.
CC       {ECO:0000269|PubMed:18332146}.
CC   -!- FUNCTION: The 1,2-PD-specific bacterial microcompartment (BMC)
CC       concentrates low levels of 1,2-PD catabolic enzymes, concentrates
CC       volatile reaction intermediates thus enhancing pathway flux and keeps
CC       the level of toxic, mutagenic propionaldehyde low.
CC       {ECO:0000305|PubMed:20417607}.
CC   -!- PATHWAY: Polyol metabolism; 1,2-propanediol degradation.
CC       {ECO:0000269|PubMed:18332146}.
CC   -!- SUBUNIT: Interacts with shell protein PduK.
CC       {ECO:0000269|PubMed:20417607}.
CC   -!- SUBCELLULAR LOCATION: Bacterial microcompartment
CC       {ECO:0000250|UniProtKB:Q9XDN4}.
CC   -!- SIMILARITY: Belongs to the PduM family. {ECO:0000305}.
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DR   EMBL; AM498294; CAM57293.1; -; Genomic_DNA.
DR   RefSeq; WP_049040282.1; NZ_LIDR01000043.1.
DR   GeneID; 66273913; -.
DR   UniPathway; UPA00621; -.
DR   GO; GO:0031469; C:bacterial microcompartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0051144; P:propanediol catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR030992; PduM.
DR   Pfam; PF15953; PDU_like; 1.
DR   TIGRFAMs; TIGR04493; microcomp_PduM; 1.
PE   1: Evidence at protein level;
KW   Bacterial microcompartment.
FT   CHAIN           1..163
FT                   /note="Bacterial microcompartment assembly protein PduM"
FT                   /id="PRO_0000454265"
SQ   SEQUENCE   163 AA;  18175 MW;  E44264C5C37B92B5 CRC64;
     MNNELLQRII EEVVSRLKKR AESTLSLSVA QLREIEPRTL CCQYSSLHLL QADLPLLEQI
     AEGCADNMSV VTIHEALACG VRVKISLQHR LLPAIPVRKL ARLPLEFSDE LGRIIVLHPD
     KLLSYADVAQ LKGGVLVLRR RCVVTALAQD AVGTRNVQLI KQE