PDX1_HUMAN
ID PDX1_HUMAN Reviewed; 283 AA.
AC P52945; O60594; Q5VYW2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 204.
DE RecName: Full=Pancreas/duodenum homeobox protein 1;
DE Short=PDX-1;
DE AltName: Full=Glucose-sensitive factor;
DE Short=GSF;
DE AltName: Full=Insulin promoter factor 1;
DE Short=IPF-1;
DE AltName: Full=Insulin upstream factor 1;
DE Short=IUF-1;
DE AltName: Full=Islet/duodenum homeobox-1;
DE Short=IDX-1;
DE AltName: Full=Somatostatin-transactivating factor 1;
DE Short=STF-1;
GN Name=PDX1; Synonyms=IPF1, STF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7590740; DOI=10.1006/geno.1995.1120;
RA Stoffel M., Stein R., Wright C.V., Espinosa R. III, le Beau M.M.,
RA Bell G.I.;
RT "Localization of human homeodomain transcription factor insulin promoter
RT factor 1 (IPF1) to chromosome band 13q12.1.";
RL Genomics 28:125-126(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Pancreatic islet;
RX PubMed=8635654; DOI=10.2337/diab.45.6.789;
RA Inoue H., Riggs A.C., Tanizawa Y., Ueda K., Kuwano A., Liu L.,
RA Donis-Keller H., Permutt M.A.;
RT "Isolation, characterization, and chromosomal mapping of the human insulin
RT promoter factor 1 (IPF-1) gene.";
RL Diabetes 45:789-794(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreatic islet;
RA Hiroshi I.;
RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreatic islet;
RA Marshak S., Totary H., Cerasi E., Melloul D.;
RL Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hara M., Lindner T.H., Paz V.P., Wang X., Iwasaki N., Bell G.I.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=9252422; DOI=10.1074/jbc.272.33.20936;
RA Macfarlane W.M., Smith S.B., James R.F., Clifton A.D., Doza Y.N., Cohen P.,
RA Docherty K.;
RT "The p38/reactivating kinase mitogen-activated protein kinase cascade
RT mediates the activation of the transcription factor insulin upstream factor
RT 1 and insulin gene transcription by high glucose in pancreatic beta-
RT cells.";
RL J. Biol. Chem. 272:20936-20944(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP INVOLVEMENT IN PAGEN1.
RX PubMed=8988180; DOI=10.1038/ng0197-106;
RA Stoffers D.A., Zinkin N.T., Stanojevic V., Clarke W.L., Habener J.F.;
RT "Pancreatic agenesis attributable to a single nucleotide deletion in the
RT human IPF1 gene coding sequence.";
RL Nat. Genet. 15:106-110(1997).
RN [10]
RP INVOLVEMENT IN MODY4.
RX PubMed=9326926; DOI=10.1038/ng1097-138;
RA Stoffers D.A., Ferrer J., Clarke W.L., Habener J.F.;
RT "Early-onset type-II diabetes mellitus (MODY4) linked to IPF1.";
RL Nat. Genet. 17:138-139(1997).
RN [11]
RP INTERACTION WITH SETD7.
RX PubMed=16141209; DOI=10.1074/jbc.m505741200;
RA Francis J., Chakrabarti S.K., Garmey J.C., Mirmira R.G.;
RT "Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation
RT during activation of insulin transcription.";
RL J. Biol. Chem. 280:36244-36253(2005).
RN [12]
RP PHOSPHORYLATION AT SER-268 BY HIPK2.
RX PubMed=20637728; DOI=10.1016/j.bbrc.2010.07.035;
RA An R., da Silva Xavier G., Semplici F., Vakhshouri S., Hao H.X., Rutter J.,
RA Pagano M.A., Meggio F., Pinna L.A., Rutter G.A.;
RT "Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is
RT HIPK2-dependent and affects PDX1 subnuclear localization.";
RL Biochem. Biophys. Res. Commun. 399:155-161(2010).
RN [13]
RP VARIANTS ARG-18; ASN-76 AND HIS-197.
RX PubMed=10545530; DOI=10.1172/jci7449;
RA Macfarlane W.M., Frayling T.M., Ellard S., Evans J.C., Allen L.I.,
RA Bulman M.P., Ayres S., Shepherd M., Clark P., Millward A., Demaine A.,
RA Wilkin T., Docherty K., Hattersley A.T.;
RT "Missense mutations in the insulin promoter factor-1 gene predispose to
RT type 2 diabetes.";
RL J. Clin. Invest. 104:R33-R39(1999).
RN [14]
RP VARIANTS LEU-59; ASN-76 AND PRO-243 INS.
RX PubMed=10545531; DOI=10.1172/jci7469;
RA Hani E.H., Stoffers D.A., Chevre J.-C., Durand E., Stanojevic V., Dina C.,
RA Habener J.F., Froguel P.;
RT "Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-
RT onset type 2 diabetes mellitus.";
RL J. Clin. Invest. 104:R41-R48(1999).
CC -!- FUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid
CC polypeptide and glucose transporter type 2 gene transcription.
CC Particularly involved in glucose-dependent regulation of insulin gene
CC transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic
CC acinar cells is involved in the transcriptional activation of the ELA1
CC enhancer; the complex binds to the enhancer B element and cooperates
CC with the transcription factor 1 complex (PTF1) bound to the enhancer A
CC element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During
CC development, specifies the early pancreatic epithelium, permitting its
CC proliferation, branching and subsequent differentiation. At adult
CC stage, required for maintaining the hormone-producing phenotype of the
CC beta-cell.
CC -!- SUBUNIT: Interacts with the basic helix-loop-helix domains of TCF3(E47)
CC and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).
CC Interacts with the methyltransferase SETD7. Part of a PDX1:PBX1b:MEIS2b
CC complex. {ECO:0000250, ECO:0000269|PubMed:16141209}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells
CC and small subsets of endocrine non-beta-cells, at low levels in acinar
CC cells).
CC -!- DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX
CC on a regulatory element of the somatostatin promoter. {ECO:0000250}.
CC -!- DOMAIN: The homeodomain, which contains the nuclear localization
CC signal, not only mediates DNA-binding, but also acts as a protein-
CC protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y).
CC {ECO:0000250}.
CC -!- PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose
CC concentration. Phosphorylated by HIPK2 on Ser-268 upon glucose
CC accumulation. This phosphorylation mediates subnuclear localization
CC shifting. Phosphorylation by PASK may lead to translocation into the
CC cytosol (By similarity). {ECO:0000250}.
CC -!- DISEASE: Pancreatic agenesis 1 (PAGEN1) [MIM:260370]: A disease
CC characterized by isolated hypoplasia or agenesis of the pancreas,
CC pancreatic beta-cell failure resulting in neonatal insulin-dependent
CC diabetes mellitus, and exocrine pancreatic insufficiency.
CC {ECO:0000269|PubMed:8988180}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]:
CC A multifactorial disorder of glucose homeostasis caused by a lack of
CC sensitivity to the body's own insulin. Affected individuals usually
CC have an obese body habitus and manifestations of a metabolic syndrome
CC characterized by diabetes, insulin resistance, hypertension and
CC hypertriglyceridemia. The disease results in long-term complications
CC that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease
CC susceptibility is associated with variants affecting the gene
CC represented in this entry.
CC -!- DISEASE: Maturity-onset diabetes of the young 4 (MODY4) [MIM:606392]: A
CC form of diabetes that is characterized by an autosomal dominant mode of
CC inheritance, onset in childhood or early adulthood (usually before 25
CC years of age), a primary defect in insulin secretion and frequent
CC insulin-independence at the beginning of the disease.
CC {ECO:0000269|PubMed:9326926}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: According to PubMed:16141209, it may be methylated by
CC SETD7 in vitro. However, the relevance of methylation is unsure in
CC vivo. {ECO:0000269|PubMed:16141209}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8
CC subfamily. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/PDX1ID43921ch13q12.html";
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DR EMBL; U35632; AAA88820.1; -; mRNA.
DR EMBL; S82178; AAB47101.1; -; Genomic_DNA.
DR EMBL; S82168; AAB47101.1; JOINED; Genomic_DNA.
DR EMBL; U30329; AAA74012.1; -; mRNA.
DR EMBL; X99894; CAA68169.1; -; mRNA.
DR EMBL; AF035260; AAB88463.1; -; Genomic_DNA.
DR EMBL; AF035259; AAB88463.1; JOINED; Genomic_DNA.
DR EMBL; AF049893; AAC05157.1; -; mRNA.
DR EMBL; AL353195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08420.1; -; Genomic_DNA.
DR CCDS; CCDS9327.1; -.
DR PIR; G01926; G01926.
DR RefSeq; NP_000200.1; NM_000209.3.
DR PDB; 6F8F; X-ray; 2.00 A; G=223-233.
DR PDB; 7KPK; X-ray; 1.71 A; B=265-283.
DR PDBsum; 6F8F; -.
DR PDBsum; 7KPK; -.
DR AlphaFoldDB; P52945; -.
DR BMRB; P52945; -.
DR SMR; P52945; -.
DR BioGRID; 109860; 16.
DR ELM; P52945; -.
DR IntAct; P52945; 2.
DR MINT; P52945; -.
DR STRING; 9606.ENSP00000370421; -.
DR iPTMnet; P52945; -.
DR PhosphoSitePlus; P52945; -.
DR BioMuta; PDX1; -.
DR DMDM; 1708540; -.
DR jPOST; P52945; -.
DR MassIVE; P52945; -.
DR PaxDb; P52945; -.
DR PeptideAtlas; P52945; -.
DR PRIDE; P52945; -.
DR ProteomicsDB; 56554; -.
DR Antibodypedia; 22687; 901 antibodies from 39 providers.
DR DNASU; 3651; -.
DR Ensembl; ENST00000381033.5; ENSP00000370421.4; ENSG00000139515.6.
DR GeneID; 3651; -.
DR KEGG; hsa:3651; -.
DR MANE-Select; ENST00000381033.5; ENSP00000370421.4; NM_000209.4; NP_000200.1.
DR UCSC; uc001urt.3; human.
DR CTD; 3651; -.
DR DisGeNET; 3651; -.
DR GeneCards; PDX1; -.
DR GeneReviews; PDX1; -.
DR HGNC; HGNC:6107; PDX1.
DR HPA; ENSG00000139515; Group enriched (intestine, pancreas).
DR MalaCards; PDX1; -.
DR MIM; 125853; phenotype.
DR MIM; 260370; phenotype.
DR MIM; 600733; gene.
DR MIM; 606392; phenotype.
DR neXtProt; NX_P52945; -.
DR OpenTargets; ENSG00000139515; -.
DR Orphanet; 99885; Isolated permanent neonatal diabetes mellitus.
DR Orphanet; 552; MODY.
DR Orphanet; 2805; Partial pancreatic agenesis.
DR PharmGKB; PA162399173; -.
DR VEuPathDB; HostDB:ENSG00000139515; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000162542; -.
DR HOGENOM; CLU_087401_0_0_1; -.
DR InParanoid; P52945; -.
DR OMA; HTWKGQW; -.
DR OrthoDB; 1102286at2759; -.
DR PhylomeDB; P52945; -.
DR TreeFam; TF326223; -.
DR PathwayCommons; P52945; -.
DR Reactome; R-HSA-210745; Regulation of gene expression in beta cells.
DR Reactome; R-HSA-210747; Regulation of gene expression in early pancreatic precursor cells.
DR SignaLink; P52945; -.
DR SIGNOR; P52945; -.
DR BioGRID-ORCS; 3651; 10 hits in 1089 CRISPR screens.
DR ChiTaRS; PDX1; human.
DR GeneWiki; PDX1; -.
DR GenomeRNAi; 3651; -.
DR Pharos; P52945; Tbio.
DR PRO; PR:P52945; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; P52945; protein.
DR Bgee; ENSG00000139515; Expressed in islet of Langerhans and 29 other tissues.
DR Genevisible; P52945; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:BHF-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc.
DR GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0051594; P:detection of glucose; ISS:BHF-UCL.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR GO; GO:0030073; P:insulin secretion; IDA:BHF-UCL.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:2000675; P:negative regulation of type B pancreatic cell apoptotic process; IEA:Ensembl.
DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL.
DR GO; GO:0010942; P:positive regulation of cell death; IEA:Ensembl.
DR GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
DR GO; GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:1904692; P:positive regulation of type B pancreatic cell proliferation; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043279; P:response to alkaloid; IEA:Ensembl.
DR GO; GO:0010157; P:response to chlorate; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0070542; P:response to fatty acid; IEA:Ensembl.
DR GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR GO; GO:0010040; P:response to iron(II) ion; IEA:Ensembl.
DR GO; GO:0043201; P:response to leucine; IEA:Ensembl.
DR GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
DR GO; GO:0033273; P:response to vitamin; IEA:Ensembl.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
DR GO; GO:0060290; P:transdifferentiation; IEA:Ensembl.
DR GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR GO; GO:0003309; P:type B pancreatic cell differentiation; IDA:BHF-UCL.
DR GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR DisProt; DP01597; -.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Cytoplasm; Developmental protein;
KW Diabetes mellitus; Disease variant; DNA-binding; Homeobox; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..283
FT /note="Pancreas/duodenum homeobox protein 1"
FT /id="PRO_0000049147"
FT DNA_BIND 146..205
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 13..73
FT /note="Transactivation domain"
FT /evidence="ECO:0000250"
FT REGION 34..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 118..123
FT /note="Antp-type hexapeptide"
FT MOTIF 197..203
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 37..52
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 151
FT /note="Phosphothreonine; by PASK"
FT /evidence="ECO:0000250|UniProtKB:P52946"
FT MOD_RES 268
FT /note="Phosphoserine; by HIPK2"
FT /evidence="ECO:0000269|PubMed:20637728"
FT VARIANT 18
FT /note="C -> R (risk factor for type 2 diabetes;
FT dbSNP:rs137852785)"
FT /evidence="ECO:0000269|PubMed:10545530"
FT /id="VAR_009309"
FT VARIANT 59
FT /note="Q -> L (risk factor for type 2 diabetes;
FT dbSNP:rs137852784)"
FT /evidence="ECO:0000269|PubMed:10545531"
FT /id="VAR_009310"
FT VARIANT 76
FT /note="D -> N (risk factor for type 2 diabetes;
FT dbSNP:rs137852783)"
FT /evidence="ECO:0000269|PubMed:10545530,
FT ECO:0000269|PubMed:10545531"
FT /id="VAR_009311"
FT VARIANT 197
FT /note="R -> H (risk factor for type 2 diabetes;
FT dbSNP:rs137852786)"
FT /evidence="ECO:0000269|PubMed:10545530"
FT /id="VAR_009312"
FT VARIANT 243
FT /note="P -> PP (risk factor for type 2 diabetes)"
FT /evidence="ECO:0000269|PubMed:10545531"
FT /id="VAR_009313"
FT CONFLICT 56
FT /note="A -> S (in Ref. 6; AAC05157)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="Q -> H (in Ref. 6; AAC05157)"
FT /evidence="ECO:0000305"
FT CONFLICT 210..211
FT /note="GG -> SS (in Ref. 6; AAC05157)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 283 AA; 30771 MW; 5D48EC8D3289F72B CRC64;
MNGEEQYYAA TQLYKDPCAF QRGPAPEFSA SPPACLYMGR QPPPPPPHPF PGALGALEQG
SPPDISPYEV PPLADDPAVA HLHHHLPAQL ALPHPPAGPF PEGAEPGVLE EPNRVQLPFP
WMKSTKAHAW KGQWAGGAYA AEPEENKRTR TAYTRAQLLE LEKEFLFNKY ISRPRRVELA
VMLNLTERHI KIWFQNRRMK WKKEEDKKRG GGTAVGGGGV AEPEQDCAVT SGEELLALPP
PPPPGGAVPP AAPVAAREGR LPPGLSASPQ PSSVAPRRPQ EPR
