ID   PDX1_XENLA              Reviewed;         271 AA.
AC   P14837;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Pancreas/duodenum homeobox protein 1;
DE            Short=PDX-1;
DE   AltName: Full=Homeobox protein 8;
DE            Short=XlHbox-8;
GN   Name=pdx1; Synonyms=lhbox8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gama L.;
RL   Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-271, SUBCELLULAR LOCATION, AND
RP   TISSUE SPECIFICITY.
RX   PubMed=2574662; DOI=10.1242/dev.105.4.787;
RA   Wright C.V.E., Schnegelsberg P., De Robertis E.M.;
RT   "XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of
RT   endoderm.";
RL   Development 105:787-794(1989).
RN   [3]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16751182; DOI=10.1101/gad.378706;
RA   Afelik S., Chen Y., Pieler T.;
RT   "Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable
RT   conversion of posterior endoderm into endocrine and exocrine pancreatic
RT   tissue.";
RL   Genes Dev. 20:1441-1446(2006).
CC   -!- FUNCTION: Acts together with ptf1a to induce the pancreatic lineage
CC       within the endoderm. {ECO:0000269|PubMed:16751182}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000269|PubMed:2574662}.
CC   -!- TISSUE SPECIFICITY: In embryos, expressed in the anteroposterior band
CC       of the endoderm, with expression continuing in cells of the pancreatic
CC       anlagen and duodenum. {ECO:0000269|PubMed:16751182,
CC       ECO:0000269|PubMed:2574662}.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X16849; CAA34746.1; -; Genomic_DNA.
DR   PIR; S07818; S07818.
DR   RefSeq; NP_001165682.1; NM_001172211.1.
DR   AlphaFoldDB; P14837; -.
DR   BMRB; P14837; -.
DR   SMR; P14837; -.
DR   GeneID; 100337610; -.
DR   KEGG; xla:100337610; -.
DR   CTD; 100337610; -.
DR   Xenbase; XB-GENE-6464311; pdx1.S.
DR   OrthoDB; 1102286at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100337610; Expressed in pancreas and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..271
FT                   /note="Pancreas/duodenum homeobox protein 1"
FT                   /id="PRO_0000049006"
FT   DNA_BIND        147..206
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          204..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           119..124
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        234..264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        256
FT                   /note="P -> S (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   271 AA;  31406 MW;  024C41F509001037 CRC64;
     MNADDQYYPQ APIYKEPCAF QRSQGQDYNP SPPACLYMGR QQQAAYSNPL VALDPGSPPD
     ISPYEVPPIS EEPIVPHLHH HHYHHHHHHP GIPHPHHQMP FPDDNESGTL EERNRTLLPF
     PWMKSTKSHT WKGQWTDGSY IMEQEENKRT RTAYTRAQLL ELEKEFLFNK YISRPRRVEL
     AVMLNLTERH IKIWFQNRRM KWKKEEDKKR GRGSDPEQDS VVSSADVLKD EPQCLGNSQK
     TGDLVLSSPL PTSSQPNQVP SIGSLRQAEK R