PDX1_XENLA
ID PDX1_XENLA Reviewed; 271 AA.
AC P14837;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Pancreas/duodenum homeobox protein 1;
DE Short=PDX-1;
DE AltName: Full=Homeobox protein 8;
DE Short=XlHbox-8;
GN Name=pdx1; Synonyms=lhbox8;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Gama L.;
RL Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 165-271, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=2574662; DOI=10.1242/dev.105.4.787;
RA Wright C.V.E., Schnegelsberg P., De Robertis E.M.;
RT "XlHbox 8: a novel Xenopus homeo protein restricted to a narrow band of
RT endoderm.";
RL Development 105:787-794(1989).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16751182; DOI=10.1101/gad.378706;
RA Afelik S., Chen Y., Pieler T.;
RT "Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable
RT conversion of posterior endoderm into endocrine and exocrine pancreatic
RT tissue.";
RL Genes Dev. 20:1441-1446(2006).
CC -!- FUNCTION: Acts together with ptf1a to induce the pancreatic lineage
CC within the endoderm. {ECO:0000269|PubMed:16751182}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:2574662}.
CC -!- TISSUE SPECIFICITY: In embryos, expressed in the anteroposterior band
CC of the endoderm, with expression continuing in cells of the pancreatic
CC anlagen and duodenum. {ECO:0000269|PubMed:16751182,
CC ECO:0000269|PubMed:2574662}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8
CC subfamily. {ECO:0000305}.
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DR EMBL; X16849; CAA34746.1; -; Genomic_DNA.
DR PIR; S07818; S07818.
DR RefSeq; NP_001165682.1; NM_001172211.1.
DR AlphaFoldDB; P14837; -.
DR BMRB; P14837; -.
DR SMR; P14837; -.
DR GeneID; 100337610; -.
DR KEGG; xla:100337610; -.
DR CTD; 100337610; -.
DR Xenbase; XB-GENE-6464311; pdx1.S.
DR OrthoDB; 1102286at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 100337610; Expressed in pancreas and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..271
FT /note="Pancreas/duodenum homeobox protein 1"
FT /id="PRO_0000049006"
FT DNA_BIND 147..206
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 204..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 119..124
FT /note="Antp-type hexapeptide"
FT COMPBIAS 234..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 256
FT /note="P -> S (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31406 MW; 024C41F509001037 CRC64;
MNADDQYYPQ APIYKEPCAF QRSQGQDYNP SPPACLYMGR QQQAAYSNPL VALDPGSPPD
ISPYEVPPIS EEPIVPHLHH HHYHHHHHHP GIPHPHHQMP FPDDNESGTL EERNRTLLPF
PWMKSTKSHT WKGQWTDGSY IMEQEENKRT RTAYTRAQLL ELEKEFLFNK YISRPRRVEL
AVMLNLTERH IKIWFQNRRM KWKKEEDKKR GRGSDPEQDS VVSSADVLKD EPQCLGNSQK
TGDLVLSSPL PTSSQPNQVP SIGSLRQAEK R