ID   A41_VACCC               Reviewed;         219 AA.
AC   P21064;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Protein A41;
DE   Flags: Precursor;
GN   ORFNames=A41L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: May interact with several cellular chemokines to interfere
CC       with chemokine-glycosaminoglycan (GAG) interactions at the cell surface
CC       to alter chemotaxis of nearby responsive cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A41 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48172.1; -; Genomic_DNA.
DR   PIR; G42521; G42521.
DR   SMR; P21064; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0039553; P:suppression by virus of host chemokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.240.10; -; 1.
DR   InterPro; IPR003184; Orthopox_35kDa.
DR   InterPro; IPR036540; Pox_vCCI-like_sf.
DR   Pfam; PF02250; Orthopox_35kD; 1.
DR   SUPFAM; SSF49889; SSF49889; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host-virus interaction;
KW   Inhibition of host chemokines by virus; Reference proteome; Secreted;
KW   Signal; Viral immunoevasion.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..219
FT                   /note="Protein A41"
FT                   /id="PRO_0000040602"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  25093 MW;  18EC70E1F0D7AAD3 CRC64;
     MYSLLFIILM CIPFSFQTVY DDKSVCDSDN KEYMGIEVYV EATLDEPLRQ TTCESEIHKY
     GASVSNGGLN ISVDLLNCFL NFHTVGVYTN RDTVYAKFAS LDPWTTEPIN SMTHDDLVKL
     TEECIVDIYL KCEVDKTKDF MKTNGNRLKP RDFKTVPPSD VGSMIELQSD YCVNDVTAYV
     KIYDECGNIK QHSIPTLRDY FTTKNGQPRK ILKKKFDNC