A41_VACCW
ID A41_VACCW Reviewed; 219 AA.
AC P24766; Q76ZN6;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein A41;
DE Flags: Precursor;
GN OrderedLocusNames=VACWR166; ORFNames=A41L;
OS Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS WR)).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10254;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1846491; DOI=10.1016/0042-6822(91)90077-o;
RA Howard S.T., Chan Y.S., Smith G.L.;
RT "Vaccinia virus homologues of the Shope fibroma virus inverted terminal
RT repeat proteins and a discontinuous ORF related to the tumor necrosis
RT factor receptor family.";
RL Virology 180:633-647(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA Smith G.L., Chan Y.S., Howard S.T.;
RT "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT right inverted terminal repeat.";
RL J. Gen. Virol. 72:1349-1376(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
RX PubMed=1870190; DOI=10.1128/jvi.65.9.4598-4608.1991;
RA Blasco R., Cole N.B., Moss B.;
RT "Sequence analysis, expression, and deletion of a vaccinia virus gene
RT encoding a homolog of profilin, a eukaryotic actin-binding protein.";
RL J. Virol. 65:4598-4608(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA Wohlhueter R.;
RT "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT redundancy and an error rate of 0.16/10kb.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=11514718; DOI=10.1099/0022-1317-82-9-2095;
RA Ng A., Tscharke D.C., Reading P.C., Smith G.L.;
RT "The vaccinia virus A41L protein is a soluble 30 kDa glycoprotein that
RT affects virus virulence.";
RL J. Gen. Virol. 82:2095-2105(2001).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 21-219.
RX PubMed=18208323; DOI=10.1371/journal.ppat.0040005;
RA Bahar M.W., Kenyon J.C., Putz M.M., Abrescia N.G., Pease J.E., Wise E.L.,
RA Stuart D.I., Smith G.L., Grimes J.M.;
RT "Structure and function of A41, a vaccinia virus chemokine binding
RT protein.";
RL PLoS Pathog. 4:E5-E5(2008).
CC -!- FUNCTION: May interact with several cellular chemokines to interfere
CC with chemokine-glycosaminoglycan (GAG) interactions at the cell surface
CC to alter chemotaxis of nearby responsive cells.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11514718}.
CC -!- SIMILARITY: Belongs to the chordopoxvirinae A41 family. {ECO:0000305}.
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DR EMBL; M58052; AAA48341.1; -; Genomic_DNA.
DR EMBL; D11079; BAA01814.1; -; Genomic_DNA.
DR EMBL; M72474; AAA48307.1; -; Genomic_DNA.
DR EMBL; AY243312; AAO89445.1; -; Genomic_DNA.
DR PIR; JQ1778; JQ1778.
DR RefSeq; YP_233048.1; NC_006998.1.
DR PDB; 2VGA; X-ray; 1.90 A; A=21-219.
DR PDBsum; 2VGA; -.
DR SMR; P24766; -.
DR IntAct; P24766; 10.
DR MINT; P24766; -.
DR DNASU; 3707696; -.
DR GeneID; 3707696; -.
DR KEGG; vg:3707696; -.
DR EvolutionaryTrace; P24766; -.
DR Proteomes; UP000000344; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0039553; P:suppression by virus of host chemokine activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.240.10; -; 1.
DR InterPro; IPR003184; Orthopox_35kDa.
DR InterPro; IPR036540; Pox_vCCI-like_sf.
DR Pfam; PF02250; Orthopox_35kD; 1.
DR SUPFAM; SSF49889; SSF49889; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Early protein; Glycoprotein; Host-virus interaction;
KW Inhibition of host chemokines by virus; Reference proteome; Secreted;
KW Signal; Viral immunoevasion.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..219
FT /note="Protein A41"
FT /id="PRO_0000040603"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT STRAND 29..46
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 54..58
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 61..66
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 69..77
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 84..90
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 93..99
FT /evidence="ECO:0007829|PDB:2VGA"
FT TURN 103..105
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 106..108
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 111..113
FT /evidence="ECO:0007829|PDB:2VGA"
FT HELIX 114..123
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 125..132
FT /evidence="ECO:0007829|PDB:2VGA"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 165..168
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 173..192
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 197..203
FT /evidence="ECO:0007829|PDB:2VGA"
FT STRAND 210..212
FT /evidence="ECO:0007829|PDB:2VGA"
SQ SEQUENCE 219 AA; 25093 MW; 905CE997BBC605D1 CRC64;
MYSLVFVILM CIPFSFQTVY DDKSVCDSDN KEYMGIEVYV EATLDEPLRQ TTCESKIHKY
GASVSNGGLN ISVDLLNCFL NFHTVGVYTN RDTVYAKFAS LDPWTTEPIN SMTHDDLVKL
TEECIVDIYL KCEVDKTKDF MKTNGNRLKP RDFKTVPPSN VGSMIELQSD YCVNDVTTYV
KIYDECGNIK QHSIPTLRDY FTTKNGQPRK ILKKKFDNC
