ID   A41_VAR67               Reviewed;         218 AA.
AC   P33854;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Protein A41;
DE   Flags: Precursor;
GN   ORFNames=A41L, A46L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=India-1967 / Isolate Ind3;
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: May interact with several cellular chemokines to interfere
CC       with chemokine-glycosaminoglycan (GAG) interactions at the cell surface
CC       to alter chemotaxis of nearby responsive cells. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A41 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49093.1; -; Genomic_DNA.
DR   PIR; B36853; B36853.
DR   RefSeq; NP_042196.1; NC_001611.1.
DR   SMR; P33854; -.
DR   PRIDE; P33854; -.
DR   GeneID; 1486527; -.
DR   KEGG; vg:1486527; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0039553; P:suppression by virus of host chemokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.240.10; -; 1.
DR   InterPro; IPR003184; Orthopox_35kDa.
DR   InterPro; IPR036540; Pox_vCCI-like_sf.
DR   Pfam; PF02250; Orthopox_35kD; 1.
DR   SUPFAM; SSF49889; SSF49889; 1.
PE   3: Inferred from homology;
KW   Early protein; Glycoprotein; Host-virus interaction;
KW   Inhibition of host chemokines by virus; Reference proteome; Secreted;
KW   Signal; Viral immunoevasion.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..218
FT                   /note="Protein A41"
FT                   /id="PRO_0000040604"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   218 AA;  24999 MW;  CCFF2D647A06ED86 CRC64;
     MYSLVFVILM CIPFSFQTVY DDKSVCDSDN KEYMGIEVYV EATLDEPLRQ TTCESEIHKY
     GASVSNGGLN ISVDLLNCFL NFHTVGVYTN RDTVYAKFTS LDPWTMEPIN SMTYDDLVKL
     TEECIVDIYL KCEVDKTKDF IKTNGNRLKP RDFKTVPPNV GSIIELQSDY CVNDVTAYVK
     IYDECGNIKQ HSIPTLRDYF TTTNGQPRKI LKKKFDNC