ID   PDXD1_BOVIN             Reviewed;         787 AA.
AC   A7MBC2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Pyridoxal-dependent decarboxylase domain-containing protein 1;
DE            EC=4.1.1.-;
GN   Name=PDXDC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC151480; AAI51481.1; -; mRNA.
DR   RefSeq; NP_001095329.1; NM_001101859.2.
DR   AlphaFoldDB; A7MBC2; -.
DR   SMR; A7MBC2; -.
DR   STRING; 9913.ENSBTAP00000043763; -.
DR   iPTMnet; A7MBC2; -.
DR   PaxDb; A7MBC2; -.
DR   PeptideAtlas; A7MBC2; -.
DR   PRIDE; A7MBC2; -.
DR   Ensembl; ENSBTAT00000046463; ENSBTAP00000043763; ENSBTAG00000004801.
DR   GeneID; 505868; -.
DR   KEGG; bta:505868; -.
DR   CTD; 23042; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004801; -.
DR   eggNOG; KOG0630; Eukaryota.
DR   GeneTree; ENSGT00390000009628; -.
DR   HOGENOM; CLU_014327_0_0_1; -.
DR   InParanoid; A7MBC2; -.
DR   OMA; RYCPLEL; -.
DR   OrthoDB; 804210at2759; -.
DR   TreeFam; TF313101; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000004801; Expressed in saliva-secreting gland and 107 other tissues.
DR   ExpressionAtlas; A7MBC2; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Phosphoprotein; Pyridoxal phosphate;
KW   Reference proteome.
FT   CHAIN           1..787
FT                   /note="Pyridoxal-dependent decarboxylase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000311215"
FT   REGION          29..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        683..701
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         653
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
FT   MOD_RES         688
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99K01"
FT   MOD_RES         692
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
FT   MOD_RES         711
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
FT   MOD_RES         719
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
FT   MOD_RES         723
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
FT   MOD_RES         747
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99K01"
FT   MOD_RES         785
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P996"
SQ   SEQUENCE   787 AA;  86615 MW;  9303DF36A3167EDB CRC64;
     MDASLEKKIA DPTLAEMGKN LKEAMKMLED SQRRTEEENG KKLLSGDIPG PLQGSGQDMV
     SILQLVQNLM HGDEDEQPQS TRIQNIGEQG HISLLGHSLG AYISTLDKEK LRKLTTRILS
     DTTLWLCRIF RYENGCAYFH EEEREGLAKI CRLAIHSRYE DFVVDGFNVL YNRKPVLYLS
     AAARPGLGQY LCNQLGLPFP CLCRVPCNTV FGSQHQMDVA FLEKLIKDDI ERGKLPLLLV
     ANAGTAAVGH TDKIGRLKEV CEQYGIWLHV EGVNLATLAL GYVSSSVLAA TKCDSMTLTP
     GPWLGLPAVP AVTLYKHDDP ALTLVSGLTS NKPADKLRAL PLWLSLQYLG LDGIVERIKH
     ACQLSQRLQE SLKKVNHIKI LVEDELSSPV VVFRFFQELP GSDPGLNAIP APSAAASAVG
     RERHSCDALN RWLGEQLKQL VPMSGLTVMD LEVEGTCVRF SPLMTAAVLG TRGEDVDQLV
     ACVQSKLPVL TCTLQLREEF KQEVEATAGL LYVDDPNWPG IGVVRYEHAN DDKSSLKLDP
     EGEKIHAGLL KKLNELESDL TFKMGPEYKS MKSCIYIGMA SDDIDISELV ETIAVTAREI
     EEDSRLLENM TEVVRKGIQE AQVQLQKANE ERLLEEGVLR QIPVVGSVLN WFSPVQASQK
     GRTFNLTAGS LESTEHTYVY KVQGSGVTPP QTPTGTRTKQ RLPGQKPFKR SLRGSDAISE
     TSSVGHIEDL EKMEQSSGGQ EASEANSHER HPEAPAPPEA EPPGALQDGA QGLQDDRPQV
     EEPESLR