ID   PDXD1_XENLA             Reviewed;         782 AA.
AC   Q6DF78;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Pyridoxal-dependent decarboxylase domain-containing protein 1;
DE            EC=4.1.1.-;
GN   Name=pdxdc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000305}.
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DR   EMBL; BC076864; AAH76864.1; -; mRNA.
DR   RefSeq; NP_001086603.1; NM_001093134.1.
DR   AlphaFoldDB; Q6DF78; -.
DR   SMR; Q6DF78; -.
DR   MaxQB; Q6DF78; -.
DR   PRIDE; Q6DF78; -.
DR   DNASU; 446438; -.
DR   GeneID; 446438; -.
DR   KEGG; xla:446438; -.
DR   CTD; 446438; -.
DR   Xenbase; XB-GENE-1005634; pdxdc1.L.
DR   OMA; RYCPLEL; -.
DR   OrthoDB; 804210at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 446438; Expressed in stomach and 19 other tissues.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
PE   2: Evidence at transcript level;
KW   Decarboxylase; Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..782
FT                   /note="Pyridoxal-dependent decarboxylase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000297679"
FT   REGION          26..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          673..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          702..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          726..782
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        673..689
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..782
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   782 AA;  86206 MW;  8F55EFFE74A7EDCB CRC64;
     MQKQIPQMVD PTLAEMGKNL DEAMKILEDN QRPSEEEKDG KKYTRKDIPG PLQGSGQNMV
     SVLQLVQNLM HDDEEEQSPS LRRIQNVGEQ GHMALLGHSL AAYISVLDRE HLRKLTTRIL
     SDTTLWLCRL FRYDNGSAYY HEDDREGLLK VCRLVIHSRY EDYTTDGFNV LYNKLPVIYI
     SAASRPGLGQ SVCNQLGLPL SCLCRVPCNT MFGSQHEMDV ALLDRLIKDD IQSGKCPLLL
     VANAGTPGAG HTDKLGRLKE LCDQYNIWLH VEGVNLATLA LGYVSSSVLA ATKCDSMTLT
     LGPWLGLPAV PAVTLYRHED PSLSLAAGLT SSQPVEKLRA LPLWLSLQYL GHSGIVERIK
     HASQLSQKLL ENLKNLSPVK TPVENDGSSP VVVFRFVYEG CKSDSTLNLS TIERDSDALN
     QWLGDQLAAL VPSSGVDIVE LEDEGTCVRF NPLMTCAVLG TTAEDVEQLV ACLRMKIPVL
     ENTLRLKEEF RQEVERIAGL SYINDYSWAG LGVLRYEQFS EEQDAAKREA DLEKITVALL
     KKLNELETDL TFCSGPEFGA EKNCIYIGMA SEDLDVSELV ETITAMGREI EENSRLLENM
     TEVVRKGILE AEVQLNKANE ERLLEEGVLR QIPLVGSMLN WLSPVQATPK GRTFNLTAGS
     LETTEMTYIS KAQTTGLTPP PTPTSAHGKR QAGQKLFKRL SRNSDAMSET SSISHLEEVE
     SLEALPMPEY DSSAAENSAM GEPFATAEQS STPSIVPTET SSEGSQEPSI PSANTAESDS
     LR