PDXH_YEAST
ID PDXH_YEAST Reviewed; 200 AA.
AC Q06608; D6W4H3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Pyridoxamine 5'-phosphate oxidase homolog;
DE AltName: Full=PNP/PMP oxidase homolog;
DE Short=PNPOx homolog;
GN OrderedLocusNames=YPR172W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC Note=Binds 1 FMN per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the pyridoxamine 5'-phosphate oxidase family.
CC {ECO:0000305}.
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DR EMBL; U25842; AAB68106.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11589.1; -; Genomic_DNA.
DR PIR; S59830; S59830.
DR RefSeq; NP_015498.1; NM_001184269.1.
DR AlphaFoldDB; Q06608; -.
DR SMR; Q06608; -.
DR BioGRID; 36345; 91.
DR DIP; DIP-2793N; -.
DR IntAct; Q06608; 2.
DR MINT; Q06608; -.
DR STRING; 4932.YPR172W; -.
DR iPTMnet; Q06608; -.
DR MaxQB; Q06608; -.
DR PaxDb; Q06608; -.
DR PRIDE; Q06608; -.
DR EnsemblFungi; YPR172W_mRNA; YPR172W; YPR172W.
DR GeneID; 856302; -.
DR KEGG; sce:YPR172W; -.
DR SGD; S000006376; YPR172W.
DR VEuPathDB; FungiDB:YPR172W; -.
DR eggNOG; ENOG502S00X; Eukaryota.
DR GeneTree; ENSGT00940000176627; -.
DR HOGENOM; CLU_078856_1_0_1; -.
DR OMA; HPTIIMT; -.
DR BioCyc; YEAST:G3O-34299-MON; -.
DR PRO; PR:Q06608; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06608; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR Gene3D; 2.30.110.10; -; 1.
DR InterPro; IPR011576; Pyridox_Oxase_put.
DR InterPro; IPR012349; Split_barrel_FMN-bd.
DR Pfam; PF01243; Putative_PNPOx; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Flavoprotein; FMN; Nucleus; Reference proteome.
FT CHAIN 1..200
FT /note="Pyridoxamine 5'-phosphate oxidase homolog"
FT /id="PRO_0000257818"
FT BINDING 60
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
FT BINDING 68
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
FT BINDING 125
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000250"
SQ SEQUENCE 200 AA; 22508 MW; 51BF02EC3941C687 CRC64;
MAWTSTLPAH LLNLIKNSKY VHVATCSKDC IPSVALMNYI YVPGEKLFGQ TDNKNDYIIF
VSPQDTQKFY NIKENPKVAL LFHDWIIANN LSVGKESISG TPTPTSIPHE EQRQSELLNL
LQELNQAELN QMSASIGGET EIVNPESEES KYYKDLILKA NPDAKAFIFE KNTAVVKVRI
DNARVSNNEN RTMFLSKGKS
