ID   A43_VACCC               Reviewed;         194 AA.
AC   P21065;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 54.
DE   RecName: Full=Protein A43;
DE   Flags: Precursor;
GN   ORFNames=A43R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus A43R protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48174.1; -; Genomic_DNA.
DR   PIR; I42521; I42521.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009487; Orthopox_A43R.
DR   Pfam; PF06517; Orthopox_A43R; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Late protein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..194
FT                   /note="Protein A43"
FT                   /id="PRO_0000099331"
FT   TOPO_DOM        23..165
FT                   /note="Extracellular"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..194
FT                   /note="Cytoplasmic"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22635 MW;  639990229C05591F CRC64;
     MMMMKWIISI LTMSIMPVLA YSSSIFRFHS EDVELCYGHL YFDRIYNVVN IKYNPHIPYR
     YNFINRTLTV DELDDNVFFT HGYFLKHKYG SLNPSLIVSL SGNLKYNDIQ CSVNVSCLIK
     NLATSTSTIL TSKHKTYSLH RSTCITIIGY DSIIWYKDIN DKYNDIYDFT AICMLIASTL
     IVTIYVFKKI KMNS