ID   A43_VAR67               Reviewed;         195 AA.
AC   P0DSY5; P33855;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   12-AUG-2020, entry version 5.
DE   RecName: Full=Protein A43;
DE   Flags: Precursor;
GN   ORFNames=A43R, A46R, A48R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus A43R protein family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49095.1; -; Genomic_DNA.
DR   PIR; D36853; D36853.
DR   RefSeq; NP_042198.1; NC_001611.1.
DR   GeneID; 1486529; -.
DR   KEGG; vg:1486529; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009487; Orthopox_A43R.
DR   Pfam; PF06517; Orthopox_A43R; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Late protein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..195
FT                   /note="Protein A43"
FT                   /id="PRO_0000099333"
FT   TOPO_DOM        23..166
FT                   /note="Extracellular"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..195
FT                   /note="Cytoplasmic"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  22783 MW;  FCF4519DFBC7A8EF CRC64;
     MMIKWIISIL TMSIMPVLVY SSSIFRFRSE DVELCYGNLY FDRIYNNVVN IKYIPEHIPY
     KYNFINRTFS VDELDNNVFF THGYFLKHKY GSLNPSLIVS LSGNLKYNDI QCSVNVSCLI
     KNLATSISTI LTSKHKTYSL HRSKCITIIG YDSIIWYKDI NDKYNDIYDF TAICMLIAST
     LIVTIYVFKK IKMNS