ID   A43_VARV                Reviewed;         195 AA.
AC   P0DSY6; P33855;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Protein A43;
DE   Flags: Precursor;
GN   ORFNames=A43R, A46R, A48R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Harvey;
RX   PubMed=1331292; DOI=10.1099/0022-1317-73-11-2887;
RA   Aguado B., Selmes I.P., Smith G.L.;
RT   "Nucleotide sequence of 21.8 kbp of variola major virus strain Harvey and
RT   comparison with vaccinia virus.";
RL   J. Gen. Virol. 73:2887-2902(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus A43R protein family.
CC       {ECO:0000305}.
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DR   EMBL; L22579; AAA60898.1; -; Genomic_DNA.
DR   PIR; H72169; H72169.
DR   PIR; T28588; T28588.
DR   RefSeq; NP_042198.1; NC_001611.1.
DR   GeneID; 1486529; -.
DR   KEGG; vg:1486529; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR009487; Orthopox_A43R.
DR   Pfam; PF06517; Orthopox_A43R; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host membrane; Late protein; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..195
FT                   /note="Protein A43"
FT                   /id="PRO_0000448166"
FT   TOPO_DOM        23..166
FT                   /note="Extracellular"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..195
FT                   /note="Cytoplasmic"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        115
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  22783 MW;  FCF4519DFBC7A8EF CRC64;
     MMIKWIISIL TMSIMPVLVY SSSIFRFRSE DVELCYGNLY FDRIYNNVVN IKYIPEHIPY
     KYNFINRTFS VDELDNNVFF THGYFLKHKY GSLNPSLIVS LSGNLKYNDI QCSVNVSCLI
     KNLATSISTI LTSKHKTYSL HRSKCITIIG YDSIIWYKDI NDKYNDIYDF TAICMLIAST
     LIVTIYVFKK IKMNS