PDYN_CAVPO
ID PDYN_CAVPO Reviewed; 245 AA.
AC Q60478;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Proenkephalin-B;
DE AltName: Full=Beta-neoendorphin-dynorphin;
DE AltName: Full=Preprodynorphin;
DE Contains:
DE RecName: Full=Alpha-neoendorphin;
DE Contains:
DE RecName: Full=Beta-neoendorphin;
DE Contains:
DE RecName: Full=Big dynorphin;
DE Short=Big Dyn;
DE Contains:
DE RecName: Full=Dynorphin A(1-17);
DE Short=Dyn-A17;
DE Short=Dynorphin A;
DE Contains:
DE RecName: Full=Dynorphin A(1-13);
DE Contains:
DE RecName: Full=Dynorphin A(1-8);
DE Contains:
DE RecName: Full=Leu-enkephalin;
DE Contains:
DE RecName: Full=Rimorphin;
DE AltName: Full=Dynorphin B;
DE Short=Dyn-B;
DE AltName: Full=Dynorphin B(1-13);
DE Contains:
DE RecName: Full=Leumorphin;
DE AltName: Full=Dynorphin B-29;
DE Flags: Precursor;
GN Name=PDYN;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Hartley; TISSUE=Adrenal gland, and Brain;
RX PubMed=8985124; DOI=10.1089/dna.1996.15.1105;
RA Yuferov V.P., Laforge K.S., Spangler R., Maggos C.E., Kreek M.J.;
RT "Guinea pig preprodynorphin mRNA: primary structure and regional
RT quantitation in the brain.";
RL DNA Cell Biol. 15:1105-1112(1996).
RN [2]
RP IDENTIFICATION OF DYNORPHIN A(1-8); DYNORPHIN A(1-17) AND
RP ALPHA-NEOENDORPHIN.
RX PubMed=2565558; DOI=10.1016/0143-4179(89)90094-2;
RA Steele P.A., Turner C.A., Murphy R.;
RT "Measurement and chromatographic characterization of prodynorphin-derived
RT peptides in the guinea-pig ileum.";
RL Neuropeptides 13:207-213(1989).
CC -!- FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate
CC drugs. They play a role in a number of physiologic functions, including
CC pain perception and responses to stress (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Dynorphin peptides differentially regulate the kappa opioid
CC receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700
CC times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Leumorphin has a typical opiod activity and may have anti-
CC apoptotic effect. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC involved in disulfide bonding and/or processing.
CC -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC {ECO:0000305}.
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DR EMBL; U38912; AAC18427.1; -; mRNA.
DR PIR; A60410; A60410.
DR RefSeq; NP_001166468.1; NM_001172997.1.
DR AlphaFoldDB; Q60478; -.
DR BMRB; Q60478; -.
DR STRING; 10141.ENSCPOP00000019436; -.
DR PRIDE; Q60478; -.
DR Ensembl; ENSCPOT00000022266; ENSCPOP00000019436; ENSCPOG00000024291.
DR GeneID; 100135596; -.
DR KEGG; cpoc:100135596; -.
DR CTD; 5173; -.
DR eggNOG; ENOG502RXT4; Eukaryota.
DR GeneTree; ENSGT00950000183149; -.
DR HOGENOM; CLU_070973_1_0_1; -.
DR InParanoid; Q60478; -.
DR OMA; NAYSGEV; -.
DR OrthoDB; 1410356at2759; -.
DR TreeFam; TF332620; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000024291; Expressed in hypothalamus and 4 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR006024; Opioid_neupept.
DR InterPro; IPR000750; Proenkphlin_B.
DR PANTHER; PTHR11438; PTHR11438; 1.
DR PANTHER; PTHR11438:SF4; PTHR11438:SF4; 1.
DR Pfam; PF01160; Opiods_neuropep; 1.
DR PRINTS; PR01028; OPIOIDPRCRSR.
DR PRINTS; PR01030; PENKBPRCRSR.
DR PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Endorphin;
KW Neuropeptide; Neurotransmitter; Opioid peptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..161
FT /id="PRO_0000008169"
FT PEPTIDE 164..173
FT /note="Alpha-neoendorphin"
FT /id="PRO_0000306341"
FT PEPTIDE 164..172
FT /note="Beta-neoendorphin"
FT /id="PRO_0000008170"
FT PEPTIDE 164..168
FT /note="Leu-enkephalin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306342"
FT PROPEP 175..195
FT /id="PRO_0000008171"
FT PEPTIDE 198..229
FT /note="Big dynorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306343"
FT PEPTIDE 198..214
FT /note="Dynorphin A(1-17)"
FT /id="PRO_0000008172"
FT PEPTIDE 198..210
FT /note="Dynorphin A(1-13)"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306344"
FT PEPTIDE 198..205
FT /note="Dynorphin A(1-8)"
FT /id="PRO_0000306345"
FT PEPTIDE 198..202
FT /note="Leu-enkephalin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306346"
FT PEPTIDE 217..245
FT /note="Leumorphin"
FT /id="PRO_0000008173"
FT PEPTIDE 217..229
FT /note="Rimorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000008174"
FT PEPTIDE 217..221
FT /note="Leu-enkephalin"
FT /id="PRO_0000008175"
SQ SEQUENCE 245 AA; 27509 MW; 719B811A3683D19B CRC64;
MVWPRLVLAA CLLAMPPAAA ECLSQCSLCA VRTQDGPKPI NPLICSLECQ ETLLPSEEWE
RCQGILSFFP SALRLRDQSG LDSRAALEEV YGELAKRARP FLQELEKSRF LPSTPAEDKF
RGLLGGLGEG LGSEAMGAPQ LNSGAVEAAA LDFDEDPKEQ VKRYGGFLRK YPKRSSEVAR
EGDRDGDNAG HEDLYKRYGG FLRRIRPKLK WDNQKRYGGF LRRQFKVVTR SQEDPNAYSE
EFFDV
