PDYN_MOUSE
ID PDYN_MOUSE Reviewed; 248 AA.
AC O35417;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Proenkephalin-B;
DE AltName: Full=Beta-neoendorphin-dynorphin;
DE AltName: Full=Preprodynorphin;
DE Contains:
DE RecName: Full=Alpha-neoendorphin;
DE Contains:
DE RecName: Full=Beta-neoendorphin;
DE Contains:
DE RecName: Full=Big dynorphin;
DE Short=Big Dyn;
DE Contains:
DE RecName: Full=Dynorphin A(1-17);
DE Short=Dyn-A17;
DE Short=Dynorphin A;
DE Contains:
DE RecName: Full=Dynorphin A(1-13);
DE Contains:
DE RecName: Full=Dynorphin A(1-8);
DE Contains:
DE RecName: Full=Leu-enkephalin;
DE Contains:
DE RecName: Full=Rimorphin;
DE AltName: Full=Dynorphin B;
DE Short=Dyn-B;
DE AltName: Full=Dynorphin B(1-13);
DE Contains:
DE RecName: Full=Leumorphin;
DE AltName: Full=Dynorphin B-29;
DE Flags: Precursor;
GN Name=Pdyn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=9751516; DOI=10.1210/endo.139.10.6233;
RA Josefsen K., Buschard K., Sorensen L.R., Wollike M., Ekman R.,
RA Birkenbach M.;
RT "Glucose stimulation of pancreatic beta-cell lines induces expression and
RT secretion of dynorphin.";
RL Endocrinology 139:4329-4336(1998).
RN [2]
RP FUNCTION.
RX PubMed=2409273;
RA Werz M.A., Macdonald R.L.;
RT "Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron
RT calcium-dependent action potential duration.";
RL J. Pharmacol. Exp. Ther. 234:49-56(1985).
RN [3]
RP FUNCTION.
RX PubMed=16292317; DOI=10.1038/sj.npp.1300959;
RA Kuzmin A., Madjid N., Terenius L., Ogren S.O., Bakalkin G.;
RT "Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-
RT mediated effects on memory, anxiolytic-like and locomotor behavior in
RT mice.";
RL Neuropsychopharmacology 31:1928-1937(2006).
CC -!- FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate
CC drugs. They play a role in a number of physiologic functions, including
CC pain perception and responses to stress (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Dynorphin peptides differentially regulate the kappa opioid
CC receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700
CC times more potent than Leu-enkephalin (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Leumorphin has a typical opiod activity and may have anti-
CC apoptotic effect. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC involved in disulfide bonding and/or processing.
CC -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC {ECO:0000305}.
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DR EMBL; AF026537; AAB82584.1; -; mRNA.
DR CCDS; CCDS38239.1; -.
DR AlphaFoldDB; O35417; -.
DR BMRB; O35417; -.
DR STRING; 10090.ENSMUSP00000028883; -.
DR iPTMnet; O35417; -.
DR PhosphoSitePlus; O35417; -.
DR PaxDb; O35417; -.
DR PRIDE; O35417; -.
DR ProteomicsDB; 287663; -.
DR MGI; MGI:97535; Pdyn.
DR eggNOG; ENOG502RXT4; Eukaryota.
DR InParanoid; O35417; -.
DR PhylomeDB; O35417; -.
DR Reactome; R-MMU-111885; Opioid Signalling.
DR Reactome; R-MMU-202040; G-protein activation.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR PRO; PR:O35417; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O35417; protein.
DR GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0099013; C:neuronal dense core vesicle lumen; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:MGI.
DR GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007600; P:sensory perception; IBA:GO_Central.
DR InterPro; IPR006024; Opioid_neupept.
DR InterPro; IPR000750; Proenkphlin_B.
DR PANTHER; PTHR11438; PTHR11438; 1.
DR PANTHER; PTHR11438:SF4; PTHR11438:SF4; 1.
DR Pfam; PF01160; Opiods_neuropep; 1.
DR PRINTS; PR01028; OPIOIDPRCRSR.
DR PRINTS; PR01030; PENKBPRCRSR.
DR PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Endorphin;
KW Neuropeptide; Neurotransmitter; Opioid peptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..163
FT /id="PRO_0000008183"
FT PEPTIDE 166..175
FT /note="Alpha-neoendorphin"
FT /id="PRO_0000306353"
FT PEPTIDE 166..174
FT /note="Beta-neoendorphin"
FT /id="PRO_0000008184"
FT PEPTIDE 166..170
FT /note="Leu-enkephalin"
FT /id="PRO_0000008185"
FT PROPEP 177..199
FT /id="PRO_0000008186"
FT PEPTIDE 202..233
FT /note="Big dynorphin"
FT /id="PRO_0000306354"
FT PEPTIDE 202..218
FT /note="Dynorphin A(1-17)"
FT /id="PRO_0000008187"
FT PEPTIDE 202..214
FT /note="Dynorphin A(1-13)"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306355"
FT PEPTIDE 202..209
FT /note="Dynorphin A(1-8)"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306356"
FT PEPTIDE 202..206
FT /note="Leu-enkephalin"
FT /id="PRO_0000008188"
FT PEPTIDE 221..248
FT /note="Leumorphin"
FT /id="PRO_0000008189"
FT PEPTIDE 221..233
FT /note="Rimorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306357"
FT PEPTIDE 221..225
FT /note="Leu-enkephalin"
FT /id="PRO_0000008190"
FT REGION 175..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 28055 MW; EDD49766CCD5DA6E CRC64;
MAWSRLMLAA CLLVMPSNVM ADCLSLCSLC AVRIQDGPRP INPLICSLEC QDLVPPSEEW
ETCRGFSSFL TLTVSGLRGK DDLEDEVALE EGISAHAKLL EPVLKELEKS RLLTSVPEEK
FRGLSSSFGN GKESELAGAD RMNDEAAQGR TVHFNEEDLR KQAKRYGGFL RKYPKRSSEM
ARDEDGGQDG DQVGHEDLYK RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN
TYSEDLDV
