ID   PDZ11_BOVIN             Reviewed;         140 AA.
AC   Q32LE7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=PDZ domain-containing protein 11;
GN   Name=PDZD11;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates docking of ADAM10 to zonula adherens by interacting
CC       with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-
CC       binding protein TSPAN33. {ECO:0000250|UniProtKB:Q5EBL8}.
CC   -!- SUBUNIT: Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A (By
CC       similarity). Interacts with PLEKHA7 (via WW domains) at zonula
CC       adherens; this interaction is essential for the interaction between
CC       PLEKHA7 and the ADAM10-binding protein TSPAN33 (By similarity).
CC       Interacts with SLC5A6 (By similarity). {ECO:0000250|UniProtKB:Q5EBL8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5EBL8}. Cell
CC       junction, adherens junction {ECO:0000250|UniProtKB:Q9CZG9}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q9CZG9}.
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DR   EMBL; BC109619; AAI09620.1; -; mRNA.
DR   RefSeq; NP_001032692.1; NM_001037603.1.
DR   RefSeq; XP_005228068.1; XM_005228011.3.
DR   AlphaFoldDB; Q32LE7; -.
DR   SMR; Q32LE7; -.
DR   STRING; 9913.ENSBTAP00000017091; -.
DR   PaxDb; Q32LE7; -.
DR   PRIDE; Q32LE7; -.
DR   Ensembl; ENSBTAT00000017091; ENSBTAP00000017091; ENSBTAG00000012860.
DR   GeneID; 515371; -.
DR   KEGG; bta:515371; -.
DR   CTD; 51248; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012860; -.
DR   VGNC; VGNC:32724; PDZD11.
DR   eggNOG; KOG3528; Eukaryota.
DR   GeneTree; ENSGT00940000153222; -.
DR   HOGENOM; CLU_133335_0_0_1; -.
DR   InParanoid; Q32LE7; -.
DR   OMA; ERIYHSD; -.
DR   OrthoDB; 1530562at2759; -.
DR   TreeFam; TF318964; -.
DR   Reactome; R-BTA-196780; Biotin transport and metabolism.
DR   Reactome; R-BTA-199220; Vitamin B5 (pantothenate) metabolism.
DR   Reactome; R-BTA-425397; Transport of vitamins, nucleosides, and related molecules.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000012860; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0046930; C:pore complex; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
DR   GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0046931; P:pore complex assembly; IEA:Ensembl.
DR   GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..140
FT                   /note="PDZ domain-containing protein 11"
FT                   /id="PRO_0000246777"
FT   DOMAIN          47..129
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ   SEQUENCE   140 AA;  16155 MW;  58299B0DAB01EF66 CRC64;
     MDSRIPYDDY PVVFLPAYEN PPAWIPPHER VYHPDYNNEL TQFLPRIVTL KKPPGAQLGF
     NIRGGKASQL GIFISKVIPD SDAHRAGLQE GDQVLAVNDV DFQDIEHSKA VEILKTAREI
     SMRVRFFPYN YHRQKERTVH