PDZ1I_HUMAN
ID PDZ1I_HUMAN Reviewed; 114 AA.
AC Q13113; Q6ICT9; Q96EI1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=PDZK1-interacting protein 1;
DE AltName: Full=17 kDa membrane-associated protein;
DE AltName: Full=Protein DD96;
GN Name=PDZK1IP1; Synonyms=MAP17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=9815914;
RA Kocher O., Cheresh P., Brown L.F., Lee S.W.;
RT "Identification of a novel gene, selectively up-regulated in human
RT carcinomas, using the differential display technique.";
RL Clin. Cancer Res. 1:1209-1215(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP CHARACTERIZATION.
RX PubMed=8701988;
RA Kocher O., Cheresh P., Lee S.W.;
RT "Identification and partial characterization of a novel membrane-associated
RT protein (MAP17) up-regulated in human carcinomas and modulating cell
RT replication and tumor growth.";
RL Am. J. Pathol. 149:493-500(1996).
RN [7]
RP INTERACTION WITH PDZK1.
RX PubMed=9461128;
RA Kocher O., Comella N., Tognazzi K., Brown L.F.;
RT "Identification and partial characterization of PDZK1: a novel protein
RT containing PDZ interaction domains.";
RL Lab. Invest. 78:117-125(1998).
RN [8]
RP INTERACTION WITH SLC5A2.
RX PubMed=34880493; DOI=10.1038/s41586-021-04212-9;
RA Niu Y., Liu R., Guan C., Zhang Y., Chen Z., Hoerer S., Nar H., Chen L.;
RT "Structural basis of inhibition of the human SGLT2-MAP17 glucose
RT transporter.";
RL Nature 601:280-284(2022).
CC -!- FUNCTION: May play an important role in tumor biology.
CC -!- SUBUNIT: Interacts with PDZK1 (PubMed:9461128). Forms a heterodimer
CC with SLC5A2; this interaction enhances SLC5A2 transporter activity over
CC a hundred-fold (PubMed:34880493). {ECO:0000269|PubMed:34880493,
CC ECO:0000269|PubMed:9461128}.
CC -!- INTERACTION:
CC Q13113; Q8TD06: AGR3; NbExp=3; IntAct=EBI-716063, EBI-3925742;
CC Q13113; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-716063, EBI-11957045;
CC Q13113; P02652: APOA2; NbExp=3; IntAct=EBI-716063, EBI-1171525;
CC Q13113; P05090: APOD; NbExp=3; IntAct=EBI-716063, EBI-715495;
CC Q13113; P05067: APP; NbExp=3; IntAct=EBI-716063, EBI-77613;
CC Q13113; P05067-2: APP; NbExp=3; IntAct=EBI-716063, EBI-17264467;
CC Q13113; P41181: AQP2; NbExp=3; IntAct=EBI-716063, EBI-12701138;
CC Q13113; Q13520: AQP6; NbExp=3; IntAct=EBI-716063, EBI-13059134;
CC Q13113; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-716063, EBI-11343438;
CC Q13113; P07306: ASGR1; NbExp=3; IntAct=EBI-716063, EBI-1172335;
CC Q13113; P54253: ATXN1; NbExp=6; IntAct=EBI-716063, EBI-930964;
CC Q13113; O14523: C2CD2L; NbExp=3; IntAct=EBI-716063, EBI-12822627;
CC Q13113; P60033: CD81; NbExp=3; IntAct=EBI-716063, EBI-712921;
CC Q13113; P23141-3: CES1; NbExp=3; IntAct=EBI-716063, EBI-12360993;
CC Q13113; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-716063, EBI-12256978;
CC Q13113; O43169: CYB5B; NbExp=3; IntAct=EBI-716063, EBI-1058710;
CC Q13113; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-716063, EBI-2680384;
CC Q13113; P50570-2: DNM2; NbExp=3; IntAct=EBI-716063, EBI-10968534;
CC Q13113; Q9BV81: EMC6; NbExp=3; IntAct=EBI-716063, EBI-2820492;
CC Q13113; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-716063, EBI-711490;
CC Q13113; Q92520: FAM3C; NbExp=3; IntAct=EBI-716063, EBI-2876774;
CC Q13113; Q8N3T1: GALNT15; NbExp=3; IntAct=EBI-716063, EBI-3925203;
CC Q13113; P01350: GAST; NbExp=3; IntAct=EBI-716063, EBI-3436637;
CC Q13113; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-716063, EBI-6166686;
CC Q13113; Q14416: GRM2; NbExp=3; IntAct=EBI-716063, EBI-10232876;
CC Q13113; P02724: GYPA; NbExp=3; IntAct=EBI-716063, EBI-702665;
CC Q13113; P09601: HMOX1; NbExp=3; IntAct=EBI-716063, EBI-2806151;
CC Q13113; P42858: HTT; NbExp=21; IntAct=EBI-716063, EBI-466029;
CC Q13113; O60725: ICMT; NbExp=3; IntAct=EBI-716063, EBI-11721771;
CC Q13113; P24593: IGFBP5; NbExp=3; IntAct=EBI-716063, EBI-720480;
CC Q13113; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-716063, EBI-10266796;
CC Q13113; O95214: LEPROTL1; NbExp=3; IntAct=EBI-716063, EBI-750776;
CC Q13113; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-716063, EBI-2820517;
CC Q13113; P30301: MIP; NbExp=3; IntAct=EBI-716063, EBI-8449636;
CC Q13113; Q96S97: MYADM; NbExp=3; IntAct=EBI-716063, EBI-13301517;
CC Q13113; A6NDP7: MYADML2; NbExp=3; IntAct=EBI-716063, EBI-17641390;
CC Q13113; Q8N912: NRAC; NbExp=3; IntAct=EBI-716063, EBI-12051377;
CC Q13113; P42857: NSG1; NbExp=3; IntAct=EBI-716063, EBI-6380741;
CC Q13113; Q96CV9: OPTN; NbExp=3; IntAct=EBI-716063, EBI-748974;
CC Q13113; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-716063, EBI-981985;
CC Q13113; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-716063, EBI-12092917;
CC Q13113; Q9BXM7: PINK1; NbExp=3; IntAct=EBI-716063, EBI-2846068;
CC Q13113; Q04941: PLP2; NbExp=3; IntAct=EBI-716063, EBI-608347;
CC Q13113; Q5VZY2: PLPP4; NbExp=3; IntAct=EBI-716063, EBI-10485931;
CC Q13113; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-716063, EBI-11721828;
CC Q13113; D3DTS7: PMP22; NbExp=3; IntAct=EBI-716063, EBI-25882629;
CC Q13113; Q01453: PMP22; NbExp=3; IntAct=EBI-716063, EBI-2845982;
CC Q13113; O60260-5: PRKN; NbExp=6; IntAct=EBI-716063, EBI-21251460;
CC Q13113; P49768-2: PSEN1; NbExp=6; IntAct=EBI-716063, EBI-11047108;
CC Q13113; P49810: PSEN2; NbExp=3; IntAct=EBI-716063, EBI-2010251;
CC Q13113; Q9NS64: RPRM; NbExp=3; IntAct=EBI-716063, EBI-1052363;
CC Q13113; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-716063, EBI-10244780;
CC Q13113; O00560: SDCBP; NbExp=3; IntAct=EBI-716063, EBI-727004;
CC Q13113; P11686: SFTPC; NbExp=3; IntAct=EBI-716063, EBI-10197617;
CC Q13113; Q96NB2: SFXN2; NbExp=3; IntAct=EBI-716063, EBI-6381136;
CC Q13113; P78383: SLC35B1; NbExp=3; IntAct=EBI-716063, EBI-12147661;
CC Q13113; Q969S0: SLC35B4; NbExp=3; IntAct=EBI-716063, EBI-10281213;
CC Q13113; P37840: SNCA; NbExp=3; IntAct=EBI-716063, EBI-985879;
CC Q13113; P00441: SOD1; NbExp=3; IntAct=EBI-716063, EBI-990792;
CC Q13113; P0DN84: STRIT1; NbExp=3; IntAct=EBI-716063, EBI-12200293;
CC Q13113; Q86Y82: STX12; NbExp=3; IntAct=EBI-716063, EBI-2691717;
CC Q13113; P07204: THBD; NbExp=3; IntAct=EBI-716063, EBI-941422;
CC Q13113; Q96IK0: TMEM101; NbExp=3; IntAct=EBI-716063, EBI-3922699;
CC Q13113; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-716063, EBI-12845616;
CC Q13113; Q9BVC6: TMEM109; NbExp=3; IntAct=EBI-716063, EBI-1057733;
CC Q13113; P17152: TMEM11; NbExp=3; IntAct=EBI-716063, EBI-723946;
CC Q13113; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-716063, EBI-2844246;
CC Q13113; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-716063, EBI-2800360;
CC Q13113; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-716063, EBI-8638294;
CC Q13113; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-716063, EBI-2339195;
CC Q13113; Q969S6: TMEM203; NbExp=3; IntAct=EBI-716063, EBI-12274070;
CC Q13113; Q9GZU3-4: TMEM39B; NbExp=3; IntAct=EBI-716063, EBI-17572471;
CC Q13113; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-716063, EBI-6656213;
CC Q13113; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-716063, EBI-12015604;
CC Q13113; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-716063, EBI-12111910;
CC Q13113; O14798: TNFRSF10C; NbExp=3; IntAct=EBI-716063, EBI-717441;
CC Q13113; O14656-2: TOR1A; NbExp=3; IntAct=EBI-716063, EBI-25847109;
CC Q13113; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-716063, EBI-12195249;
CC Q13113; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-716063, EBI-11988865;
CC Q13113; P09936: UCHL1; NbExp=3; IntAct=EBI-716063, EBI-714860;
CC Q13113; O75841: UPK1B; NbExp=3; IntAct=EBI-716063, EBI-12237619;
CC Q13113; Q15836: VAMP3; NbExp=3; IntAct=EBI-716063, EBI-722343;
CC Q13113; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-716063, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed at significant levels only in a single
CC epithelial cell population, the proximal tubular epithelial cells of
CC the kidney. Diffusely expressed in various carcinomas originating from
CC kidney, colon, lung and breast.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/PDZK1IP1ID41268ch1p33.html";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U21049; AAA92690.1; -; mRNA.
DR EMBL; CR450304; CAG29300.1; -; mRNA.
DR EMBL; AL135960; CAB72104.1; -; Genomic_DNA.
DR EMBL; CH471059; EAX06878.1; -; Genomic_DNA.
DR EMBL; BC012303; AAH12303.1; -; mRNA.
DR CCDS; CCDS546.1; -.
DR RefSeq; NP_005755.1; NM_005764.3.
DR PDB; 7VSI; EM; 2.95 A; B=1-56.
DR PDBsum; 7VSI; -.
DR AlphaFoldDB; Q13113; -.
DR SMR; Q13113; -.
DR BioGRID; 115460; 77.
DR IntAct; Q13113; 86.
DR STRING; 9606.ENSP00000294338; -.
DR iPTMnet; Q13113; -.
DR PhosphoSitePlus; Q13113; -.
DR SwissPalm; Q13113; -.
DR BioMuta; PDZK1IP1; -.
DR DMDM; 6225642; -.
DR EPD; Q13113; -.
DR jPOST; Q13113; -.
DR MassIVE; Q13113; -.
DR PaxDb; Q13113; -.
DR PeptideAtlas; Q13113; -.
DR PRIDE; Q13113; -.
DR ProteomicsDB; 59164; -.
DR Antibodypedia; 2658; 31 antibodies from 13 providers.
DR DNASU; 10158; -.
DR Ensembl; ENST00000294338.7; ENSP00000294338.2; ENSG00000162366.8.
DR Ensembl; ENST00000371885.1; ENSP00000360952.1; ENSG00000162366.8.
DR GeneID; 10158; -.
DR KEGG; hsa:10158; -.
DR MANE-Select; ENST00000294338.7; ENSP00000294338.2; NM_005764.4; NP_005755.1.
DR UCSC; uc001cqw.4; human.
DR CTD; 10158; -.
DR DisGeNET; 10158; -.
DR GeneCards; PDZK1IP1; -.
DR HGNC; HGNC:16887; PDZK1IP1.
DR HPA; ENSG00000162366; Tissue enriched (kidney).
DR MIM; 607178; gene.
DR neXtProt; NX_Q13113; -.
DR OpenTargets; ENSG00000162366; -.
DR PharmGKB; PA142671188; -.
DR VEuPathDB; HostDB:ENSG00000162366; -.
DR eggNOG; ENOG502SAPW; Eukaryota.
DR GeneTree; ENSGT00940000154660; -.
DR HOGENOM; CLU_168651_0_0_1; -.
DR InParanoid; Q13113; -.
DR OMA; NFRSSEH; -.
DR OrthoDB; 1588365at2759; -.
DR PhylomeDB; Q13113; -.
DR TreeFam; TF328829; -.
DR PathwayCommons; Q13113; -.
DR SignaLink; Q13113; -.
DR BioGRID-ORCS; 10158; 44 hits in 1062 CRISPR screens.
DR ChiTaRS; PDZK1IP1; human.
DR GeneWiki; PDZK1IP1; -.
DR GenomeRNAi; 10158; -.
DR Pharos; Q13113; Tbio.
DR PRO; PR:Q13113; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q13113; protein.
DR Bgee; ENSG00000162366; Expressed in adult mammalian kidney and 139 other tissues.
DR Genevisible; Q13113; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026628; PDZK-int_prot1.
DR InterPro; IPR031627; PDZK1IP1/SMIM24.
DR PANTHER; PTHR15296; PTHR15296; 1.
DR PANTHER; PTHR15296:SF0; PTHR15296:SF0; 1.
DR Pfam; PF15807; MAP17; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..114
FT /note="PDZK1-interacting protein 1"
FT /id="PRO_0000058282"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 94..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9CQH0"
FT CONFLICT 13
FT /note="T -> M (in Ref. 5; AAH12303)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="N -> K (in Ref. 5; AAH12303)"
FT /evidence="ECO:0000305"
FT HELIX 29..53
FT /evidence="ECO:0007829|PDB:7VSI"
SQ SEQUENCE 114 AA; 12227 MW; 7DEB64C3AF78CB18 CRC64;
MSALSLLILG LLTAVPPASC QQGLGNLQPW MQGLIAVAVF LVLVAIAFAV NHFWCQEEPE
PAHMILTVGN KADGVLVGTD GRYSSMAASF RSSEHENAYE NVPEEEGKVR STPM
