ID   PDZ1I_MOUSE             Reviewed;         114 AA.
AC   Q9CQH0;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=PDZK1-interacting protein 1;
DE   AltName: Full=17 kDa membrane-associated protein;
GN   Name=Pdzk1ip1; Synonyms=Map17;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Pancreas, and Small intestine;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Interacts with PDZK1. Forms a heterodimer with SLC5A2; this
CC       interaction enhances SLC5A2 transporter activity over a hundred-fold.
CC       {ECO:0000250|UniProtKB:Q13113}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}.
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DR   EMBL; AK007936; BAB25361.1; -; mRNA.
DR   EMBL; AK008253; BAB25559.1; -; mRNA.
DR   EMBL; AK012305; BAB28152.1; -; mRNA.
DR   EMBL; BC013542; AAH13542.1; -; mRNA.
DR   CCDS; CCDS18487.1; -.
DR   RefSeq; NP_001158029.1; NM_001164557.1.
DR   RefSeq; NP_001158030.1; NM_001164558.1.
DR   RefSeq; NP_080294.1; NM_026018.3.
DR   AlphaFoldDB; Q9CQH0; -.
DR   SMR; Q9CQH0; -.
DR   BioGRID; 212000; 3.
DR   CORUM; Q9CQH0; -.
DR   STRING; 10090.ENSMUSP00000102158; -.
DR   iPTMnet; Q9CQH0; -.
DR   PhosphoSitePlus; Q9CQH0; -.
DR   jPOST; Q9CQH0; -.
DR   MaxQB; Q9CQH0; -.
DR   PaxDb; Q9CQH0; -.
DR   PRIDE; Q9CQH0; -.
DR   ProteomicsDB; 287664; -.
DR   Antibodypedia; 2658; 31 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000030488; ENSMUSP00000030488; ENSMUSG00000028716.
DR   Ensembl; ENSMUST00000106548; ENSMUSP00000102158; ENSMUSG00000028716.
DR   Ensembl; ENSMUST00000177647; ENSMUSP00000136049; ENSMUSG00000028716.
DR   GeneID; 67182; -.
DR   KEGG; mmu:67182; -.
DR   UCSC; uc008ueo.2; mouse.
DR   CTD; 10158; -.
DR   MGI; MGI:1914432; Pdzk1ip1.
DR   VEuPathDB; HostDB:ENSMUSG00000028716; -.
DR   eggNOG; ENOG502SAPW; Eukaryota.
DR   GeneTree; ENSGT00940000154660; -.
DR   HOGENOM; CLU_168651_0_0_1; -.
DR   InParanoid; Q9CQH0; -.
DR   OMA; NFRSSEH; -.
DR   OrthoDB; 1588365at2759; -.
DR   PhylomeDB; Q9CQH0; -.
DR   TreeFam; TF328829; -.
DR   BioGRID-ORCS; 67182; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Pdzk1ip1; mouse.
DR   PRO; PR:Q9CQH0; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q9CQH0; protein.
DR   Bgee; ENSMUSG00000028716; Expressed in right kidney and 203 other tissues.
DR   ExpressionAtlas; Q9CQH0; baseline and differential.
DR   Genevisible; Q9CQH0; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026628; PDZK-int_prot1.
DR   InterPro; IPR031627; PDZK1IP1/SMIM24.
DR   PANTHER; PTHR15296; PTHR15296; 1.
DR   PANTHER; PTHR15296:SF0; PTHR15296:SF0; 1.
DR   Pfam; PF15807; MAP17; 1.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..114
FT                   /note="PDZK1-interacting protein 1"
FT                   /id="PRO_0000058283"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         85
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   114 AA;  12298 MW;  8DF7CF00E26A0BDC CRC64;
     MLAFSLLVLG LLAEVAPASC QQGLGNLQPW MQGLIAVAVF LVLVAIVFAV NHFWCQEEPE
     PGSTVMIIGN KADGVLVGMD GRYSSMASGF RSSEHKNAYE NVLEEEGRVR STPM