PDZD2_HUMAN
ID PDZD2_HUMAN Reviewed; 2839 AA.
AC O15018; Q9BXD4;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 4.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=PDZ domain-containing protein 2;
DE AltName: Full=Activated in prostate cancer protein;
DE AltName: Full=PDZ domain-containing protein 3;
DE Contains:
DE RecName: Full=Processed PDZ domain-containing protein 2;
GN Name=PDZD2; Synonyms=AIPC, KIAA0300, PDZK3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=11289102;
RA Chaib H., Rubin M.A., Mucci N.R., Li L., Taylor J.M.G., Day M.L.,
RA Rhim J.S., Macoska J.A.;
RT "Activated in prostate cancer: a PDZ domain-containing protein highly
RT expressed in human primary prostate tumors.";
RL Cancer Res. 61:2390-2394(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-1274.
RC TISSUE=Brain;
RX PubMed=9205841; DOI=10.1093/dnares/4.2.141;
RA Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. VII. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 4:141-150(1997).
CC -!- SUBUNIT: Interacts with SCN10A, CTNND2 and PKP4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QZR8}. Cytoplasm
CC {ECO:0000269|PubMed:11289102}. Endoplasmic reticulum
CC {ECO:0000269|PubMed:11289102}. Note=At cell-cell contacts in lung
CC epithelial cells. {ECO:0000250|UniProtKB:Q9QZR8}.
CC -!- SUBCELLULAR LOCATION: [Processed PDZ domain-containing protein 2]:
CC Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O15018-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O15018-2; Sequence=VSP_012369, VSP_012370, VSP_012371,
CC VSP_012372, VSP_012373;
CC -!- TISSUE SPECIFICITY: Isoform 2 is expressed (at protein level) in
CC prostate and many prostate tumors. {ECO:0000269|PubMed:11289102}.
CC -!- PTM: A secreted form is produced by caspase-mediated proteolytic
CC cleavage. {ECO:0000250}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to aberrant splicing.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA20760.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF338650; AAK07661.1; -; mRNA.
DR EMBL; AB002298; BAA20760.2; ALT_INIT; mRNA.
DR CCDS; CCDS34137.1; -. [O15018-1]
DR RefSeq; NP_835260.2; NM_178140.3. [O15018-1]
DR RefSeq; XP_011512297.1; XM_011513995.2. [O15018-1]
DR SMR; O15018; -.
DR BioGRID; 116676; 20.
DR IntAct; O15018; 6.
DR STRING; 9606.ENSP00000402033; -.
DR GlyGen; O15018; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; O15018; -.
DR PhosphoSitePlus; O15018; -.
DR BioMuta; PDZD2; -.
DR EPD; O15018; -.
DR jPOST; O15018; -.
DR MassIVE; O15018; -.
DR MaxQB; O15018; -.
DR PaxDb; O15018; -.
DR PeptideAtlas; O15018; -.
DR PRIDE; O15018; -.
DR ProteomicsDB; 48374; -. [O15018-1]
DR ProteomicsDB; 48375; -. [O15018-2]
DR Antibodypedia; 22684; 158 antibodies from 31 providers.
DR DNASU; 23037; -.
DR Ensembl; ENST00000438447.2; ENSP00000402033.1; ENSG00000133401.16. [O15018-1]
DR GeneID; 23037; -.
DR KEGG; hsa:23037; -.
DR MANE-Select; ENST00000438447.2; ENSP00000402033.1; NM_178140.4; NP_835260.2.
DR UCSC; uc003jhl.4; human. [O15018-1]
DR CTD; 23037; -.
DR DisGeNET; 23037; -.
DR GeneCards; PDZD2; -.
DR HGNC; HGNC:18486; PDZD2.
DR HPA; ENSG00000133401; Low tissue specificity.
DR MIM; 610697; gene.
DR neXtProt; NX_O15018; -.
DR OpenTargets; ENSG00000133401; -.
DR PharmGKB; PA33164; -.
DR VEuPathDB; HostDB:ENSG00000133401; -.
DR eggNOG; KOG0708; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000157749; -.
DR HOGENOM; CLU_000714_0_0_1; -.
DR InParanoid; O15018; -.
DR OMA; ERMPKNA; -.
DR OrthoDB; 225688at2759; -.
DR PhylomeDB; O15018; -.
DR TreeFam; TF326303; -.
DR PathwayCommons; O15018; -.
DR SignaLink; O15018; -.
DR BioGRID-ORCS; 23037; 8 hits in 1076 CRISPR screens.
DR ChiTaRS; PDZD2; human.
DR GeneWiki; PDZD2; -.
DR GenomeRNAi; 23037; -.
DR Pharos; O15018; Tbio.
DR PRO; PR:O15018; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; O15018; protein.
DR Bgee; ENSG00000133401; Expressed in trigeminal ganglion and 200 other tissues.
DR ExpressionAtlas; O15018; baseline and differential.
DR Genevisible; O15018; HS.
DR GO; GO:0005911; C:cell-cell junction; ISS:UniProtKB.
DR GO; GO:0034451; C:centriolar satellite; IDA:HPA.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 6.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 5.
DR SMART; SM00228; PDZ; 6.
DR SUPFAM; SSF50156; SSF50156; 6.
DR PROSITE; PS50106; PDZ; 6.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Cytoplasm; Endoplasmic reticulum;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Secreted.
FT CHAIN 1..2839
FT /note="PDZ domain-containing protein 2"
FT /id="PRO_0000058294"
FT CHAIN ?2493..2839
FT /note="Processed PDZ domain-containing protein 2"
FT /evidence="ECO:0000250"
FT /id="PRO_0000302756"
FT DOMAIN 85..182
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 334..419
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 586..672
FT /note="PDZ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 728..813
FT /note="PDZ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 2622..2706
FT /note="PDZ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 2750..2835
FT /note="PDZ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 185..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1809..1865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..1976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2009..2079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2135..2166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2178..2211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2232..2251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2353..2383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2426..2481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2709..2729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..460
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1304..1318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1377..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1438..1456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2039..2053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2178..2196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2358..2380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2458..2481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2548..2562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 2492..2493
FT /note="Cleavage; by caspases"
FT /evidence="ECO:0000250"
FT MOD_RES 568
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZR8"
FT MOD_RES 944
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZR8"
FT MOD_RES 948
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZR8"
FT MOD_RES 1850
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZR8"
FT VAR_SEQ 375..555
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11289102"
FT /id="VSP_012369"
FT VAR_SEQ 803..817
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11289102"
FT /id="VSP_012370"
FT VAR_SEQ 909..911
FT /note="THK -> S (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11289102"
FT /id="VSP_012371"
FT VAR_SEQ 1179
FT /note="K -> KLCQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11289102"
FT /id="VSP_012372"
FT VAR_SEQ 1228..1231
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11289102"
FT /id="VSP_012373"
FT VARIANT 1178
FT /note="E -> G (in dbSNP:rs57158698)"
FT /id="VAR_061691"
FT VARIANT 1258
FT /note="Q -> K (in dbSNP:rs3101878)"
FT /id="VAR_031654"
FT VARIANT 1274
FT /note="T -> A (in dbSNP:rs157496)"
FT /evidence="ECO:0000269|PubMed:9205841"
FT /id="VAR_031655"
FT VARIANT 1343
FT /note="D -> E (in dbSNP:rs12520467)"
FT /id="VAR_031656"
FT VARIANT 1425
FT /note="T -> M (in dbSNP:rs36097367)"
FT /id="VAR_031657"
FT VARIANT 1649
FT /note="A -> V (in dbSNP:rs3101873)"
FT /id="VAR_031658"
FT VARIANT 2247
FT /note="R -> Q (in dbSNP:rs10066063)"
FT /id="VAR_031659"
FT CONFLICT 254
FT /note="P -> A (in Ref. 1; AAK07661)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="R -> RQ (in Ref. 1; AAK07661)"
FT /evidence="ECO:0000305"
FT CONFLICT 2576
FT /note="N -> K (in Ref. 1; AAK07661)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2839 AA; 301641 MW; 4B1CB91A9CE96267 CRC64;
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF AVDESTVPPD
HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR RGGKKRKTHQ GPVLDVGCIW
VTELRKNSPA GKSGKVRLRD EILSLNGQLM VGVDVSGASY LAEQCWNGGF IYLIMLRRFK
HKAHSTYNGN SSNSSEPGET PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC
EVSSDPSTEL ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP
LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG GRGSKRSPHA
IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA VAILRSATGM VQLVVASKEN
SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE DQEADGEEDE GTSSSVQRAM PGTDEPQDVC
GAEESKGNLE SPKQGSNKIK LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR
KHSLPQLLDS SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS
IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF QEAIHTFKQI
RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG ASAGGSDEGS SSSLGRKTPG
PKDRIVMEVT LNKEPRVGLG IGACCLALEN SPPGIYIHSL APGSVAKMES NLSRGDQILE
VNSVNVRHAA LSKVHAILSK CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS
SPGLGTPLKS PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE
GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ ALRNPLLRQR
KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD PRRVSISSSK GMDVHNQEER
PRKTLVSKAI SAPLLGSSVD LEESIPEGMV DAASYAANLT DSAEAPKGSP GSWWKKELSG
SSSAPKLEYT VRTDTQSPTN TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS
QTVNLTGRAN DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS
ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS KTSVDTGQVS
RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP DYSKTRSASE TSTPHNTRRV
AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE
GADSVSSRAP QASLSMLPST DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR
SPSSQTGDSG SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ
PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS MYGDAEDSSS
DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE ICSTRGCPNP PSSPAHLPTQ
AAICPASAKV LSLKYSTPRE SVASPREKAA CLPGSYTSGP DSSQPSSLLE MSSQEHETHA
DISTSQNHRP SCAEETTEVT SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD
DETLNQYETS INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA
WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS PPQPKTNLEN
KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA PAANAVKAGG TDHRKPLISP
QTSHKTLSKA VSQRLHVADH EDPDRNTTAA PRSPQCVLES KPPLATSGPL KPSVSDTSIR
TFVSPLTSPK PVPEQGMWSR FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA
SRNGMSVAGN RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV
SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH ASQAEQEMSR
SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN SIPGGPSGED HLYFTPRPAT
RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ VPVTSSVVPE AKASRGGLPS LANGQGIYSV
KPLLDTSRNL PATDEGDIIS VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK
SFENLANADR PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC
SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG IPTPTMTLAS
PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED YSAGPSAVLF KTELEITPRR
SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA AETPSSASDT GEAAQDLPFR RSWSVNLDQL
LVSAGDQQRL QSVLSSVGSK STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG
TDVEPKSITV HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA
LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC VEVLKTSAGL
GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI LAINGKPLVG LMHFDAWNIM
KSVPEGPVQL LIRKHRNSS
