PDZD4_MOUSE
ID PDZD4_MOUSE Reviewed; 772 AA.
AC Q9QY39; A2AFG4; Q6PHP2;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=PDZ domain-containing protein 4;
DE AltName: Full=PDZ domain-containing RING finger protein 4-like protein;
GN Name=Pdzd4; Synonyms=Pdzk4, Pdzrn4l, Xlu;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.;
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-772.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250}. Note=Mainly
CC localized under the plasma membrane. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH56462.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF133093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL672094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC056462; AAH56462.1; ALT_INIT; mRNA.
DR CCDS; CCDS30214.1; -.
DR RefSeq; NP_001025039.1; NM_001029868.2.
DR RefSeq; NP_001277469.1; NM_001290540.1.
DR AlphaFoldDB; Q9QY39; -.
DR SMR; Q9QY39; -.
DR STRING; 10090.ENSMUSP00000002080; -.
DR iPTMnet; Q9QY39; -.
DR PhosphoSitePlus; Q9QY39; -.
DR MaxQB; Q9QY39; -.
DR PaxDb; Q9QY39; -.
DR PRIDE; Q9QY39; -.
DR ProteomicsDB; 301782; -.
DR Antibodypedia; 578; 114 antibodies from 18 providers.
DR DNASU; 245469; -.
DR Ensembl; ENSMUST00000002080; ENSMUSP00000002080; ENSMUSG00000002006.
DR GeneID; 245469; -.
DR KEGG; mmu:245469; -.
DR UCSC; uc009tmt.1; mouse.
DR CTD; 57595; -.
DR MGI; MGI:2443483; Pdzd4.
DR VEuPathDB; HostDB:ENSMUSG00000002006; -.
DR eggNOG; KOG0312; Eukaryota.
DR GeneTree; ENSGT00950000183062; -.
DR HOGENOM; CLU_011096_1_0_1; -.
DR InParanoid; Q9QY39; -.
DR OMA; IGHEYYD; -.
DR OrthoDB; 631580at2759; -.
DR PhylomeDB; Q9QY39; -.
DR TreeFam; TF315909; -.
DR BioGRID-ORCS; 245469; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9QY39; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9QY39; protein.
DR Bgee; ENSMUSG00000002006; Expressed in cortical plate and 168 other tissues.
DR ExpressionAtlas; Q9QY39; baseline and differential.
DR Genevisible; Q9QY39; MM.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..772
FT /note="PDZ domain-containing protein 4"
FT /id="PRO_0000055922"
FT DOMAIN 136..221
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 239..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 394..424
FT /evidence="ECO:0000255"
FT COMPBIAS 286..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 242
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q76G19"
FT MOD_RES 459
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q76G19"
SQ SEQUENCE 772 AA; 86819 MW; 1D5A1BA6A6900713 CRC64;
MGCNMCVVQK PEEQYKVMLQ VNGKELSKLS QEQTLEALRA SKEPLVIQVL RRSPRLRGDS
SCHDLQLVDS GTQTDITFEH IMALGKLRPP TPPMGILEPY VLSELPPISH EYYDPAEFME
GGPQEAERMD ELEYEEVELC KNSHQDKLGL MVCYRTDEEE DLGIYVGEVN PNSIAAKDGR
IREGDRIIQI NGMDVQNREE AVAILSQEEN TNISLLVARP ESQLAKRWKD SDRDDFLDDF
GSENEGDLRA RKLKSPPVQQ IGNDEKGAPD GGPGLNNSQD LDSGVGRTDE STRNEESSEH
DLLGDEPPST TNTPGSLRKF GLQGDALQSR DFHFSMDSLL AEGAGLGGAD LPGLTDEEYE
RYRELLEIKC HLENGNQLGI FFSRASSGNS ALDVNRNESL GHEMAMLEEE LRHLEFKCRN
ILRAQKMQQL RERCMKAWLL EEESLYDLAA SEPKKHELSD ISELPEKSDK DSTSAYNTGE
SCRSTPLLVE PLPESPLKRS GAGNSNLNRT PSGPPVTTHL KGAPSPGSPA KFRSLSRDPE
VGRRQHTEER VRRSTKTSVT LERVGPEGSP YLSRRHRGQE IEQYHSCVQL APPRTLEDLG
HGSLSLASGP RVGGVAAAAV EAPRMEWKVK VRSDGTRYVA KRPVRDRLLK ARALKIREER
SGMTTDDDAV SEMKMGRYWS KEERKQHLIR AREQRKRREF MMQSRLECLR EQQNGDSKPE
LNIIALSHRK TMKKRNKKIL DNWITIQEML AHGARSADGK RIYNPLLSVT TV
