ID   PE09_MYCTU              Reviewed;         144 AA.
AC   Q79FS8; F2GGV1; I6Y9L0; L0T5N7;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=PE family protein PE9 {ECO:0000305};
GN   Name=PE9 {ECO:0000312|EMBL:CCP43840.1};
GN   OrderedLocusNames=Rv1088 {ECO:0000312|EMBL:CCP43840.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH PE10 AND TLR4, AND SUBCELLULAR LOCATION.
RX   PubMed=26031846; DOI=10.1111/cmi.12462;
RA   Tiwari B., Ramakrishnan U.M., Raghunand T.R.;
RT   "The Mycobacterium tuberculosis protein pair PE9 (Rv1088)-PE10 (Rv1089)
RT   forms heterodimers and induces macrophage apoptosis through Toll-like
RT   receptor 4.";
RL   Cell. Microbiol. 17:1653-1669(2015).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=26851205; DOI=10.1016/j.ijbiomac.2015.12.081;
RA   Diaz D.P., Ocampo M., Pabon L., Herrera C., Patarroyo M.A., Munoz M.,
RA   Patarroyo M.E.;
RT   "Mycobacterium tuberculosis PE9 protein has high activity binding peptides
RT   which inhibit target cell invasion.";
RL   Int. J. Biol. Macromol. 86:646-655(2016).
CC   -!- FUNCTION: Together with PE10, induces macrophage apoptosis through
CC       human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with
CC       TLR4 leads to increased levels of phospho-IRF-3, increase in the
CC       transcript levels of IFN-beta and pro-apoptotic genes, up-regulation of
CC       IL-10, down-regulation of IL-1b and enhanced levels of macrophage
CC       apoptosis. {ECO:0000269|PubMed:26031846}.
CC   -!- SUBUNIT: Forms a complex with PE10. The complex interacts with human
CC       TLR4. {ECO:0000269|PubMed:26031846}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:26031846}. Cell surface
CC       {ECO:0000269|PubMed:26851205}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43840.1; -; Genomic_DNA.
DR   RefSeq; WP_003900271.1; NC_000962.3.
DR   RefSeq; YP_177784.1; NC_000962.3.
DR   AlphaFoldDB; Q79FS8; -.
DR   SMR; Q79FS8; -.
DR   STRING; 83332.Rv1088; -.
DR   PaxDb; Q79FS8; -.
DR   DNASU; 887096; -.
DR   GeneID; 887096; -.
DR   KEGG; mtu:Rv1088; -.
DR   PATRIC; fig|83332.115.peg.1215; -.
DR   TubercuList; Rv1088; -.
DR   eggNOG; COG0657; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..144
FT                   /note="PE family protein PE9"
FT                   /id="PRO_0000438135"
FT   DOMAIN          1..87
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
FT   REGION          98..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  15376 MW;  8201C5443BFCCAFF CRC64;
     MSYMIATPAA LTAAATDIDG IGSAVSVANA AAVAATTGVL AAGGDEVLAA IARLFNANAE
     EYHALSAQVA AFQTLFVRTL TGGCGVFRRR RGRQCVTAAE HRAAGAGRRQ RRRRSGDGQW
     RLRQQRHFGC GGQPEFRQHS EHRR