ID   PE10_MYCTU              Reviewed;         120 AA.
AC   L0T5T4;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=PE family protein PE10 {ECO:0000305};
DE   Flags: Fragment;
GN   Name=PE10 {ECO:0000312|EMBL:CCP43841.1};
GN   OrderedLocusNames=Rv1089 {ECO:0000312|EMBL:CCP43841.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, INTERACTION WITH PE9 AND TLR4, SUBCELLULAR LOCATION, AND DOMAIN.
RX   PubMed=26031846; DOI=10.1111/cmi.12462;
RA   Tiwari B., Ramakrishnan U.M., Raghunand T.R.;
RT   "The Mycobacterium tuberculosis protein pair PE9 (Rv1088)-PE10 (Rv1089)
RT   forms heterodimers and induces macrophage apoptosis through Toll-like
RT   receptor 4.";
RL   Cell. Microbiol. 17:1653-1669(2015).
CC   -!- FUNCTION: Together with PE9, induces macrophage apoptosis through human
CC       Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4
CC       leads to increased levels of phospho-IRF-3, increase in the transcript
CC       levels of IFN-beta and pro-apoptotic genes, up-regulation of IL-10,
CC       down-regulation of IL-1b and enhanced levels of macrophage apoptosis.
CC       {ECO:0000269|PubMed:26031846}.
CC   -!- SUBUNIT: Forms a complex with PE9. The complex interacts with human
CC       TLR4. {ECO:0000269|PubMed:26031846}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:26031846}. Note=Requires PE9 for cell wall
CC       localization. {ECO:0000269|PubMed:26031846}.
CC   -!- DOMAIN: The C-terminal domain is required for interaction with TLR4 but
CC       not with PE9. {ECO:0000269|PubMed:26031846}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
CC   -!- CAUTION: Partial ORF that appears to be frameshifted continuation of
CC       Rv1088 (PE9). Sequence has been checked and appears correct. PE9 and
CC       PE10 are expressed independently of each other (PubMed:26031846).
CC       {ECO:0000269|PubMed:26031846, ECO:0000312|TubercuList:Rv1089}.
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DR   EMBL; AL123456; CCP43841.1; -; Genomic_DNA.
DR   AlphaFoldDB; L0T5T4; -.
DR   STRING; 83332.Rv1089; -.
DR   PaxDb; L0T5T4; -.
DR   TubercuList; Rv1089; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell wall; Reference proteome; Secreted; Virulence.
FT   CHAIN           <1..120
FT                   /note="PE family protein PE10"
FT                   /id="PRO_0000438136"
FT   REGION          29..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:CCP43841.1"
SQ   SEQUENCE   120 AA;  11763 MW;  B7A39418832E1807 CRC64;
     SFAGAEAANA SQLQSIARQV RGAVNAVAGQ VTGNGGSGNS GTSAAAANPN SDNTASIADR
     GTSAIMTTAS ATASSTGVDG GIAATYAVAS QWDGGYVANY TITQFGRDFD DRLAVAIHFA