ID   PE13_MYCTU              Reviewed;          99 AA.
AC   Q79FR3; I6XAW7; L0T5Y6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=PE family protein PE13 {ECO:0000305};
GN   Name=PE13 {ECO:0000312|EMBL:CCP43951.1};
GN   OrderedLocusNames=Rv1195 {ECO:0000312|EMBL:CCP43951.1};
GN   ORFNames=LH57_06555 {ECO:0000312|EMBL:AIR13942.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RA   Hazbon M.H., Riojas M.A., Damon A.M., Alalade R.O., Cantwell B.J.,
RA   Monaco A., King S., Sohrabi A.;
RT   "Phylogenetic analysis of Mycobacterial species using whole genome
RT   sequences.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   INDUCTION.
RC   STRAIN=H37Rv;
RX   PubMed=19651861; DOI=10.1128/iai.01495-08;
RA   Goldstone R.M., Goonesekera S.D., Bloom B.R., Sampson S.L.;
RT   "The transcriptional regulator Rv0485 modulates the expression of a pe and
RT   ppe gene pair and is required for Mycobacterium tuberculosis virulence.";
RL   Infect. Immun. 77:4654-4667(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=27147522; DOI=10.1007/s10495-016-1249-y;
RA   Li H., Li Q., Yu Z., Zhou M., Xie J.;
RT   "Mycobacterium tuberculosis PE13 (Rv1195) manipulates the host cell fate
RT   via p38-ERK-NF-kappaB axis and apoptosis.";
RL   Apoptosis 21:795-808(2016).
CC   -!- FUNCTION: May play a pivotal role in the interaction between
CC       M.tuberculosis and host. Can enhance the survival within macrophages
CC       under stress conditions such as H(2)O(2), SDS and low pH. Increases the
CC       production of IL-6 and IL-1beta from macrophages, and decreases the
CC       secretion of suppressor of cytokine signaling 3 (SOCS-3). These changes
CC       probably involve the p38-ERK-NF-kappa-B signaling pathway. Also
CC       precipitates the macrophage death. {ECO:0000269|PubMed:27147522}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000269|PubMed:27147522}.
CC   -!- INDUCTION: Expression is positively regulated by Rv0485
CC       (PubMed:19651861). Induced by different stress conditions such as
CC       surface stress, oxidative stress and acidic pH stress
CC       (PubMed:27147522). {ECO:0000269|PubMed:19651861,
CC       ECO:0000269|PubMed:27147522}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43951.1; -; Genomic_DNA.
DR   EMBL; CP009480; AIR13942.1; -; Genomic_DNA.
DR   RefSeq; WP_003406222.1; NZ_NVQJ01000025.1.
DR   RefSeq; YP_177794.1; NC_000962.3.
DR   AlphaFoldDB; Q79FR3; -.
DR   SMR; Q79FR3; -.
DR   STRING; 83332.Rv1195; -.
DR   PaxDb; Q79FR3; -.
DR   GeneID; 45425166; -.
DR   GeneID; 886044; -.
DR   KEGG; mtu:Rv1195; -.
DR   PATRIC; fig|83332.111.peg.1336; -.
DR   TubercuList; Rv1195; -.
DR   eggNOG; COG0657; Bacteria.
DR   HOGENOM; CLU_000167_16_11_11; -.
DR   OMA; THAARFQ; -.
DR   PhylomeDB; Q79FR3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   1: Evidence at protein level;
KW   Cell wall; Reference proteome; Secreted; Virulence.
FT   CHAIN           1..99
FT                   /note="PE family protein PE13"
FT                   /id="PRO_5007710417"
FT   DOMAIN          1..93
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   99 AA;  9616 MW;  7E6A11535307DCA3 CRC64;
     MSFVMAYPEM LAAAADTLQS IGATTVASNA AAAAPTTGVV PPAADEVSAL TAAHFAAHAA
     MYQSVSARAA AIHDQFVATL ASSASSYAAT EVANAAAAS