ID   PE14_LITPE              Reviewed;           7 AA.
AC   P86494;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   11-DEC-2019, entry version 6.
DE   RecName: Full=Peroniin-1.4;
OS   Litoria peronii (Emerald spotted tree frog) (Hyla peronii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Litoria.
OX   NCBI_TaxID=317363;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1, AND AMIDATION AT VAL-7.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:19642086};
RX   PubMed=19642086; DOI=10.1002/rcm.4164;
RA   Bilusich D., Jackway R.J., Musgrave I.F., Tyler M.J., Bowie J.H.;
RT   "The host-defence skin peptide profiles of Peron's Tree Frog Litoria
RT   peronii in winter and summer. Sequence determination by electrospray mass
RT   spectrometry and activities of the peptides.";
RL   Rapid Commun. Mass Spectrom. 23:2628-2636(2009).
CC   -!- FUNCTION: Induces contraction of intestinal smooth muscle in isolated
CC       guinea pig ileum. {ECO:0000269|PubMed:19642086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19642086}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC       {ECO:0000269|PubMed:19642086}.
CC   -!- MASS SPECTROMETRY: Mass=871; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19642086};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Peroniin subfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..7
FT                   /note="Peroniin-1.4"
FT                   /id="PRO_0000394186"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:19642086"
FT   MOD_RES         7
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:19642086"
SQ   SEQUENCE   7 AA;  890 MW;  72C9D7673361B6B0 CRC64;
     QTWLPFV