ID   PE15_MYCTO              Reviewed;         102 AA.
AC   P9WIH0; L0T842; P0A682; P71656;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=PE family immunomodulator PE15 {ECO:0000250|UniProtKB:P9WIH1};
GN   Name=PE15; OrderedLocusNames=MT1430;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: May play a pivotal role in the evasion of host immune
CC       response by M.tuberculosis. Mediates production of IL-10 via activation
CC       of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling
CC       pathways. {ECO:0000250|UniProtKB:P9WIH1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WIH1}. Cell
CC       envelope {ECO:0000250|UniProtKB:P9WIH1}. Cell surface
CC       {ECO:0000250|UniProtKB:P9WIH1}. Note=Secreted via the ESX-3 / type VII
CC       secretion system (T7SS) (By similarity). Secretion is dependent on EsxG
CC       and EsxH (By similarity). {ECO:0000250|UniProtKB:P9WIH1}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45695.1; -; Genomic_DNA.
DR   PIR; H70898; H70898.
DR   RefSeq; WP_003407225.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIH0; -.
DR   SMR; P9WIH0; -.
DR   EnsemblBacteria; AAK45695; AAK45695; MT1430.
DR   KEGG; mtc:MT1430; -.
DR   PATRIC; fig|83331.31.peg.1536; -.
DR   HOGENOM; CLU_162350_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0031975; C:envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..102
FT                   /note="PE family immunomodulator PE15"
FT                   /id="PRO_0000428008"
FT   DOMAIN          3..91
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   102 AA;  9862 MW;  8165F09DBDB9D752 CRC64;
     MTLRVVPESL AGASAAIEAV TARLAAAHAA AAPFIAAVIP PGSDSVSVCN AVEFSVHGSQ
     HVAMAAQGVE ELGRSGVGVA ESGASYAARD ALAAASYLSG GL