ID   PE15_MYCTU              Reviewed;         102 AA.
AC   P9WIH1; L0T842; P0A682; P71656;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=PE family immunomodulator PE15 {ECO:0000305};
GN   Name=PE15 {ECO:0000303|PubMed:23284742}; OrderedLocusNames=Rv1386;
GN   ORFNames=MTCY21B4.03;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23284742; DOI=10.1371/journal.pone.0051686;
RA   Tiwari B.M., Kannan N., Vemu L., Raghunand T.R.;
RT   "The Mycobacterium tuberculosis PE proteins Rv0285 and Rv1386 modulate
RT   innate immunity and mediate bacillary survival in macrophages.";
RL   PLoS ONE 7:E51686-E51686(2012).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=26729876; DOI=10.1073/pnas.1523321113;
RA   Tufariello J.M., Chapman J.R., Kerantzas C.A., Wong K.W., Vilcheze C.,
RA   Jones C.M., Cole L.E., Tinaztepe E., Thompson V., Fenyoe D., Niederweis M.,
RA   Ueberheide B., Philips J.A., Jacobs W.R. Jr.;
RT   "Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron
RT   acquisition and virulence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:E348-E357(2016).
CC   -!- FUNCTION: May play a pivotal role in the evasion of host immune
CC       response by M.tuberculosis. Mediates production of IL-10 via activation
CC       of the p38 and ERK1/2 mitogen-activated protein kinase (MAPK) signaling
CC       pathways. {ECO:0000269|PubMed:23284742}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26729876}. Cell
CC       envelope {ECO:0000269|PubMed:23284742}. Cell surface
CC       {ECO:0000269|PubMed:23284742}. Note=Secreted via the ESX-3 / type VII
CC       secretion system (T7SS) (PubMed:26729876). Secretion is dependent on
CC       EsxG and EsxH (PubMed:26729876). {ECO:0000269|PubMed:26729876}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44145.1; -; Genomic_DNA.
DR   PIR; H70898; H70898.
DR   RefSeq; WP_003407225.1; NZ_NVQJ01000050.1.
DR   RefSeq; YP_177805.1; NC_000962.3.
DR   AlphaFoldDB; P9WIH1; -.
DR   SMR; P9WIH1; -.
DR   STRING; 83332.Rv1386; -.
DR   PaxDb; P9WIH1; -.
DR   GeneID; 886757; -.
DR   KEGG; mtu:Rv1386; -.
DR   TubercuList; Rv1386; -.
DR   eggNOG; ENOG503235C; Bacteria.
DR   OMA; NYHAADT; -.
DR   PhylomeDB; P9WIH1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0031975; C:envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Virulence.
FT   CHAIN           1..102
FT                   /note="PE family immunomodulator PE15"
FT                   /id="PRO_0000023572"
FT   DOMAIN          3..91
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   102 AA;  9862 MW;  8165F09DBDB9D752 CRC64;
     MTLRVVPESL AGASAAIEAV TARLAAAHAA AAPFIAAVIP PGSDSVSVCN AVEFSVHGSQ
     HVAMAAQGVE ELGRSGVGVA ESGASYAARD ALAAASYLSG GL