PE1_ANOGA
ID PE1_ANOGA Reviewed; 153 AA.
AC O76217; Q6VAW1; Q6VAW2; Q6VAW4; Q6VAW5; Q6VAW6; Q7QID7;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Peritrophin-1;
DE AltName: Full=AgAper-1;
DE AltName: Full=Peritrophic matrix protein 1;
DE AltName: Full=Peritrophin A;
DE Flags: Precursor;
GN Name=Aper1; ORFNames=AGAP006795;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=G3; TISSUE=Midgut;
RX PubMed=9651363; DOI=10.1074/jbc.273.28.17665;
RA Shen Z., Jacobs-Lorena M.;
RT "A type I peritrophic matrix protein from the malaria vector Anopheles
RT gambiae binds to chitin. Cloning, expression, and characterization.";
RL J. Biol. Chem. 273:17665-17670(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Abraham E.G., Donnelly-Doman M., Fujioka H., Ghosh A., Moreira L.,
RA Jacobs-Lorena M.;
RT "Anopheles peritrophic matrix protein-1 (AgAper-1) regulatory sequences
RT mediate transgenic protein accumulation and secretion into the midgut lumen
RT upon blood ingestion.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=4aRR, L3-5, L3-51, Yaounde Yd21, Yaounde Yd35, and Yaounde Yd41;
RX PubMed=15642974; DOI=10.4269/ajtmh.2004.71.795;
RA Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.;
RT "Intraspecific nucleotide variation in Anopheles gambiae: new insights into
RT the biology of malaria vectors.";
RL Am. J. Trop. Med. Hyg. 71:795-802(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Binds chitin but not cellulose. May be involved in the
CC spatial organization of PM. {ECO:0000269|PubMed:9651363}.
CC -!- TISSUE SPECIFICITY: Adult peritrophic membrane.
CC {ECO:0000269|PubMed:9651363}.
CC -!- DEVELOPMENTAL STAGE: Expressed in adult but not larval guts, whole
CC pupae or whole bodies minus gut.
CC -!- PTM: Glycosylated.
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DR EMBL; AF030431; AAC39127.1; -; mRNA.
DR EMBL; AY750997; AAV31069.1; -; Genomic_DNA.
DR EMBL; AY344823; AAR02434.1; -; Genomic_DNA.
DR EMBL; AY344824; AAR02435.1; -; Genomic_DNA.
DR EMBL; AY344825; AAR02436.1; -; Genomic_DNA.
DR EMBL; AY344826; AAR02437.1; -; Genomic_DNA.
DR EMBL; AY344827; AAR02438.1; -; Genomic_DNA.
DR EMBL; AY344828; AAR02439.1; -; Genomic_DNA.
DR EMBL; AAAB01008807; EAA04177.3; -; Genomic_DNA.
DR RefSeq; XP_308952.3; XM_308952.3.
DR AlphaFoldDB; O76217; -.
DR SMR; O76217; -.
DR CAZy; CBM14; Carbohydrate-Binding Module Family 14.
DR PaxDb; O76217; -.
DR GeneID; 1270270; -.
DR KEGG; aga:AgaP_AGAP006795; -.
DR CTD; 1270270; -.
DR VEuPathDB; VectorBase:AGAP006795; -.
DR eggNOG; ENOG502R6AT; Eukaryota.
DR HOGENOM; CLU_1682355_0_0_1; -.
DR InParanoid; O76217; -.
DR OrthoDB; 1174178at2759; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR InterPro; IPR002557; Chitin-bd_dom.
DR InterPro; IPR036508; Chitin-bd_dom_sf.
DR Pfam; PF01607; CBM_14; 2.
DR SMART; SM00494; ChtBD2; 2.
DR SUPFAM; SSF57625; SSF57625; 2.
DR PROSITE; PS50940; CHIT_BIND_II; 2.
PE 2: Evidence at transcript level;
KW Chitin-binding; Disulfide bond; Glycoprotein; Reference proteome; Repeat;
KW Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..153
FT /note="Peritrophin-1"
FT /id="PRO_0000023612"
FT DOMAIN 18..79
FT /note="Chitin-binding type-2 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT DOMAIN 92..153
FT /note="Chitin-binding type-2 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 56..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT DISULFID 130..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00144"
FT VARIANT 7
FT /note="L -> V (in strain: 4aRR, PEST)"
FT VARIANT 19
FT /note="D -> V (in strain: 4aRR, PEST)"
FT VARIANT 28
FT /note="E -> K (in strain: L3-5)"
FT VARIANT 37
FT /note="P -> S (in strain: L3-5)"
FT VARIANT 55
FT /note="K -> Q (in strain: Yaounde Yd41)"
FT VARIANT 73
FT /note="A -> S (in strain: Yaounde Yd21, Yaounde Yd35,
FT Yaounde Yd41)"
FT VARIANT 88
FT /note="A -> V (in strain: G3)"
FT VARIANT 89
FT /note="P -> S (in strain: 4aRR, PEST)"
SQ SEQUENCE 153 AA; 16791 MW; 2207D5130F487338 CRC64;
MKVSASLVLL LAAAVLADDR CPPQDDPEQP PVLLAHPTDC DKFLICNHGT PVVSKCPPGL
LWNDSQKQCD YPAQAQCAPG VTPNTEPAPK PSPNCPPEYD PDHMVYIPHE TDCGKYYICD
PYGVELEQTC PSGLHWNPVV NYCDFPELAQ CEE
