ID   PE23_MYCTU              Reviewed;         382 AA.
AC   P9WIG9; L0T9H7; P0A684; P71884;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized PE family protein PE23;
GN   Name=PE23; OrderedLocusNames=Rv2328; ORFNames=MTCY3G12.06;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the mycobacterial PE family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45115.1; -; Genomic_DNA.
DR   PIR; A70705; A70705.
DR   RefSeq; WP_003411972.1; NZ_NVQJ01000012.1.
DR   RefSeq; YP_177867.1; NC_000962.3.
DR   AlphaFoldDB; P9WIG9; -.
DR   SMR; P9WIG9; -.
DR   STRING; 83332.Rv2328; -.
DR   PaxDb; P9WIG9; -.
DR   DNASU; 888111; -.
DR   GeneID; 45426311; -.
DR   GeneID; 888111; -.
DR   KEGG; mtu:Rv2328; -.
DR   TubercuList; Rv2328; -.
DR   eggNOG; COG0657; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000084; PE-PGRS_N.
DR   Pfam; PF00934; PE; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..382
FT                   /note="Uncharacterized PE family protein PE23"
FT                   /id="PRO_0000216162"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          1..92
FT                   /note="PE"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   382 AA;  36833 MW;  C26DE32096CA0380 CRC64;
     MQFLSVIPEQ VESAAQDLAG IRSALSASYA AAAGPTTAVV SAAEDEVSTA IASIFGAYGR
     QCQVLSAQAS AFHDEFVNLL KTGATAYRNT EFANAQSNVL NAVNAPARSL LGHPSAAESV
     QNSAPTLGGG HSTVTAGLAA QAGRAVATVE QQAAAAVAPL PSAGAGLAQV VNGVVTAGQG
     SAAKLATALQ SAAPWLAKSG GEFIVAGQSA LTGVALLQPA VVGVVQAGGT FLTAGTSAAT
     GLGLLTLAGV EFSQGVGNLA LASGTAATGL GLLGSAGVQL FSPAFLLAVP TALGGVGSLA
     IAVVQLVQGV QHLSLVVPNV VAGIAALQTA GAQFAQGVNH TMLAAQLGAP GIAVLQTAGG
     HFAQGIGHLT TAGNAAVTVL IS