PE2R2_MOUSE
ID PE2R2_MOUSE Reviewed; 362 AA.
AC Q62053;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Prostaglandin E2 receptor EP2 subtype;
DE Short=PGE receptor EP2 subtype;
DE Short=PGE2 receptor EP2 subtype;
DE AltName: Full=Prostanoid EP2 receptor;
GN Name=Ptger2; Synonyms=Ptgerep2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ddY; TISSUE=Lung;
RX PubMed=7556658; DOI=10.1016/0014-5793(95)00966-d;
RA Katsuyama M., Nishigaki N., Sugimoto Y., Morimoto K., Negishi M.,
RA Narumiya S., Ichikawa A.;
RT "The mouse prostaglandin E receptor EP2 subtype: cloning, expression, and
RT northern blot analysis.";
RL FEBS Lett. 372:151-156(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this
CC receptor is mediated by G(s) proteins that stimulate adenylate cyclase.
CC The subsequent raise in intracellular cAMP is responsible for the
CC relaxing effect of this receptor on smooth muscle.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; D50589; BAA09137.1; -; mRNA.
DR EMBL; BC005440; AAH05440.1; -; mRNA.
DR CCDS; CCDS26972.1; -.
DR PIR; S66674; S66674.
DR RefSeq; NP_032990.1; NM_008964.4.
DR AlphaFoldDB; Q62053; -.
DR SMR; Q62053; -.
DR STRING; 10090.ENSMUSP00000038483; -.
DR BindingDB; Q62053; -.
DR ChEMBL; CHEMBL2488; -.
DR DrugCentral; Q62053; -.
DR GuidetoPHARMACOLOGY; 341; -.
DR GlyGen; Q62053; 1 site.
DR PhosphoSitePlus; Q62053; -.
DR MaxQB; Q62053; -.
DR PaxDb; Q62053; -.
DR PRIDE; Q62053; -.
DR ProteomicsDB; 301784; -.
DR Antibodypedia; 10768; 590 antibodies from 33 providers.
DR DNASU; 19217; -.
DR Ensembl; ENSMUST00000046891; ENSMUSP00000038483; ENSMUSG00000037759.
DR GeneID; 19217; -.
DR KEGG; mmu:19217; -.
DR UCSC; uc007tgd.2; mouse.
DR CTD; 5732; -.
DR MGI; MGI:97794; Ptger2.
DR VEuPathDB; HostDB:ENSMUSG00000037759; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244902; -.
DR HOGENOM; CLU_045991_0_2_1; -.
DR InParanoid; Q62053; -.
DR OMA; FYQRWVT; -.
DR OrthoDB; 972015at2759; -.
DR PhylomeDB; Q62053; -.
DR TreeFam; TF324982; -.
DR Reactome; R-MMU-391908; Prostanoid ligand receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 19217; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Ptger2; mouse.
DR PRO; PR:Q62053; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q62053; protein.
DR Bgee; ENSMUSG00000037759; Expressed in granulocyte and 88 other tissues.
DR ExpressionAtlas; Q62053; baseline and differential.
DR Genevisible; Q62053; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004957; F:prostaglandin E receptor activity; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IDA:BHF-UCL.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:1904346; P:positive regulation of gastric mucosal blood circulation; ISO:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IGI:MGI.
DR GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
DR GO; GO:0009624; P:response to nematode; IMP:MGI.
DR GO; GO:0032570; P:response to progesterone; IDA:CACAO.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001923; Prostglndn_EP2_rcpt.
DR PANTHER; PTHR11866; PTHR11866; 1.
DR PANTHER; PTHR11866:SF8; PTHR11866:SF8; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00581; PRSTNOIDEP2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..362
FT /note="Prostaglandin E2 receptor EP2 subtype"
FT /id="PRO_0000070055"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..323
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..362
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 234..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 362 AA; 40479 MW; A79FCEE8B6771F44 CRC64;
MDNFLNDSKL MEDCKSRQWL LSGESPAISS VMFSAGVLGN LIALALLARR WRGDTGCSAG
SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL VALAPESHAC TYFAFTMTFF
SLATMLMLFA MALERYLSIG YPYFYRRHLS RRGGLAVLPV IYGASLLFCS LPLLNYGEYV
QYCPGTWCFI RHGRTAYLQL YATMLLLLIV AVLACNISVI LNLIRMHRRS RRSRCGLSGS
SLRGPGSRRR GERTSMAEET DHLILLAIMT ITFAICSLPF TIFAYMDETS SLKEKWDLRA
LRFLSVNSII DPWVFAILRP PVLRLMRSVL CCRTSLRTQE AQQTSCSTQS SASKQTDLCG
QL
