PE2R2_RAT
ID PE2R2_RAT Reviewed; 357 AA.
AC Q62928; Q547S0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Prostaglandin E2 receptor EP2 subtype;
DE Short=PGE receptor EP2 subtype;
DE Short=PGE2 receptor EP2 subtype;
DE AltName: Full=Prostanoid EP2 receptor;
GN Name=Ptger2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=9440134; DOI=10.1016/s0090-6980(97)00145-7;
RA Nemoto K., Pilbeam C.C., Bilak S.R., Raisz L.G.;
RT "Molecular cloning and expression of a rat prostaglandin E2 receptor of the
RT EP2 subtype.";
RL Prostaglandins 54:713-725(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Spleen;
RX PubMed=9537820; DOI=10.1016/s0014-2999(97)01383-6;
RA Boie Y., Stocco R., Sawyer N., Slipetz D.M., Ungrin M.D.,
RA Neuschafer-Rube F., Puschel G.P., Metters K.M., Abramovitz M.;
RT "Molecular cloning and characterization of the four rat prostaglandin E2
RT prostanoid receptor subtypes.";
RL Eur. J. Pharmacol. 340:227-241(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RA Chien E.K., Mendoza J.;
RT "Constitutive expression of Ptger-ep2 in the pregnant rat uterus.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this
CC receptor is mediated by G(s) proteins that stimulate adenylate cyclase.
CC The subsequent raise in intracellular cAMP is responsible for the
CC relaxing effect of this receptor on smooth muscle (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U48858; AAA97889.1; -; mRNA.
DR EMBL; U94708; AAB53325.1; -; mRNA.
DR EMBL; AF454964; AAM73855.1; -; Genomic_DNA.
DR RefSeq; NP_112350.1; NM_031088.1.
DR AlphaFoldDB; Q62928; -.
DR SMR; Q62928; -.
DR STRING; 10116.ENSRNOP00000064907; -.
DR BindingDB; Q62928; -.
DR ChEMBL; CHEMBL4909; -.
DR DrugCentral; Q62928; -.
DR GuidetoPHARMACOLOGY; 341; -.
DR GlyGen; Q62928; 1 site.
DR PhosphoSitePlus; Q62928; -.
DR PaxDb; Q62928; -.
DR Ensembl; ENSRNOT00000075209; ENSRNOP00000064907; ENSRNOG00000050968.
DR GeneID; 81752; -.
DR KEGG; rno:81752; -.
DR CTD; 5732; -.
DR RGD; 620020; Ptger2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244902; -.
DR HOGENOM; CLU_045991_0_2_1; -.
DR InParanoid; Q62928; -.
DR OMA; FYQRWVT; -.
DR OrthoDB; 972015at2759; -.
DR PhylomeDB; Q62928; -.
DR TreeFam; TF324982; -.
DR Reactome; R-RNO-391908; Prostanoid ligand receptors.
DR PRO; PR:Q62928; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000050968; Expressed in spleen and 11 other tissues.
DR Genevisible; Q62928; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004957; F:prostaglandin E receptor activity; IDA:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:1904346; P:positive regulation of gastric mucosal blood circulation; IDA:RGD.
DR GO; GO:0042127; P:regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; ISO:RGD.
DR GO; GO:0009624; P:response to nematode; ISO:RGD.
DR GO; GO:0032570; P:response to progesterone; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; NAS:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001923; Prostglndn_EP2_rcpt.
DR PANTHER; PTHR11866; PTHR11866; 1.
DR PANTHER; PTHR11866:SF8; PTHR11866:SF8; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00581; PRSTNOIDEP2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="Prostaglandin E2 receptor EP2 subtype"
FT /id="PRO_0000070056"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..152
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..286
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..323
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 110..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 357 AA; 39772 MW; AAB22A8280AFEFB0 CRC64;
MDNSFNDSRR VENCESRQYL LSDESPAISS VMFTAGVLGN LIALALLARR WRGDTGCSAG
SRTSISLFHV LVTELVLTDL LGTCLISPVV LASYSRNQTL VALAPESRAC TYFAFTMTFF
SLATMLMLFA MALERYLAIG HPYFYRRRVS RRGGLAVLPA IYGVSLLFCS LPLLNYGEYV
QYCPGTWCFI QHGRTAYLQL YATVLLLLIV AVLGCNISVI LNLIRMQLRS KRSRCGLSGS
SLRGPGSRRR GERTSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMDETS SRKEKWDLRA
LRFLSVNSII DPWVFVILRP PVLRLMRSVL CCRTSLRAPE APGASCSTQQ TDLCGQL
