ID   PE2R3_SHEEP             Reviewed;          89 AA.
AC   Q28550;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Prostaglandin E2 receptor EP3 subtype;
DE            Short=PGE receptor EP3 subtype;
DE            Short=PGE2 receptor EP3 subtype;
DE   AltName: Full=Prostanoid EP3 receptor;
DE   Flags: Fragment;
GN   Name=PTGER3;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney outer medulla;
RX   PubMed=9625477; DOI=10.1016/s0034-5288(98)90016-9;
RA   Audicana L., Aughey E., O'Shaughnessy P.J.;
RT   "Sensitivity of the early luteal phase ovine cervix to prostaglandin E2
RT   (PGE2) and expression of EP3 receptor mRNA.";
RL   Res. Vet. Sci. 64:177-179(1998).
CC   -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). Required for normal
CC       development of fever in response to pyrinogens, including IL1B,
CC       prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for
CC       normal potentiation of platelet aggregation by prostaglandin E2, and
CC       thus plays a role in the regulation of blood coagulation. Required for
CC       increased HCO3(-) secretion in the duodenum in response to mucosal
CC       acidification, and thereby contributes to the protection of the mucosa
CC       against acid-induced ulceration. Not required for normal kidney
CC       function, normal urine volume and osmolality.
CC       {ECO:0000250|UniProtKB:P30557}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with MKLN1.
CC       {ECO:0000250|UniProtKB:P34980}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30557};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P30557}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000305}.
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DR   EMBL; U37148; AAB81195.1; -; mRNA.
DR   AlphaFoldDB; Q28550; -.
DR   SMR; Q28550; -.
DR   STRING; 9940.ENSOARP00000012890; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004957; F:prostaglandin E receptor activity; IEA:InterPro.
DR   InterPro; IPR008365; Prostanoid_rcpt.
DR   InterPro; IPR000265; Prostglndn_EP3_rcpt.
DR   PANTHER; PTHR11866; PTHR11866; 1.
DR   PANTHER; PTHR11866:SF10; PTHR11866:SF10; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           <1..>89
FT                   /note="Prostaglandin E2 receptor EP3 subtype"
FT                   /id="PRO_0000070063"
FT   TRANSMEM        <1..18
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        19..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..74
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         89
SQ   SEQUENCE   89 AA;  9364 MW;  EDAD27E127B0A428 CRC64;
     GVWLAVLAFA LLPVLGVGQY TIQWPGTWCF ISTGPGGNGT NSRQNWGNVF FASDFAILGL
     SALVVTFACN LATIKALVSR CRAKATASQ